Search results for "PIP"

Sintesi di Piperonale tramite fotocatalisi eterogenea in condizioni green

2013

Steady, periodic, quasi-periodic and chaotic flow regimes in toroidal pipes

2012

Incompressible flow in a toroidal pipe was investigated by direct numerical simulation. The curvature a/c (radius of the cross section / radius of the torus) was 0.3 or 0.1 and the bulk Reynolds number ranged between 3500 and 14 700. The study revealed a rich scenario of transition to turbulence. For the higher curvature a/c = 0.3, a supercritical transition from stationary to periodic flow (Hopf bifurcation) was observed at Re=4600. The periodic flow was characterized by a travelling wave which, in the whole periodic Re range, took the form of a varicose modulation of the twin Dean vortex rings, included 8 wavelengths along the axis of the torus, and exhibited instantaneous anti-symmetry a…

Efficacy, safety and tolerability of aripiprazole in bipolar disorder: An updated systematic review and meta-analysis of randomized controlled trials

2017

Numerous studies have investigated aripiprazole as a treatment for bipolar disorder (BD). therefore we conducted this comprehensive meta-analysis to investigate the efficacy and safety profile of aripiprazole in treating BD. Two authors conducted systematic searches of PubMed and ScienceDirect from inception until May 14th, 2017. Randomized controlled trials (RCTs) of people with BD who received aripiprazole were included. A total of 20 RCTs met the eligibility criteria, including two which investigated the efficacy of aripiprazole versus haloperidol (aripiprazole = 340; haloperidol = 337), three which compared aripiprazole versus lithium (aripiprazole = 208; lithium = 212), and 15 with mul…

The genetic structure of the cosmopolitan three-partner lichenRamalina farinaceaevidences the concerted diversification of symbionts

2012

The epiphytic lichen Ramalina farinacea is distributed throughout the northern hemisphere in which the same two algal Trebouxia species (provisionally named TR1 and TR9) coexist in every thallus. Ramalina farinacea symbionts were characterized based on the two fungal nuclear loci (nrITS and rpb2 ) along with the primary and secondary structures of nrITS from each Trebouxia species in the Iberian Peninsula and Canary Islands. The results indicated a noticeable genetic differentiation between mycobionts from these two geographic areas and also suggested concerted changes in the three partners of a lichen symbiosis toward two clearly distinguishable ‘holobiont’ lineages. Modeling of ITS2 RNA s…

Diastereoselective synthesis of 2-phenyl-3-(trifluoromethyl)piperazines as building blocks for drug discovery.

2014

The synthesis of enantiomerically pure cis- and trans-2-phenyl-3-(trifluoromethyl)piperazines is described. It involved, as the key step, a diastereoselective nucleophilic addition of the Ruppert-Prakash reagent (TMSCF3) to alpha-amino sulfinylimines bearing Ellman's auxiliary. This methodology allows an entry into hitherto unknown trifluoromethylated and stereochemically defined piperazines, key scaffold components in medicinal chemistry.

The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-linker in the synthesis of glycopeptide partial structures of complex cell surface glycoproteins.

2003

The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL) linker represents a novel fluoride-sensitive anchor for the solid-phase synthesis of protected peptides and glycopeptides. Its cleavage is achieved under almost neutral conditions using tetrabutylammonium fluoride trihydrate in dichloromethane thus allowing the construction of complex molecules sensitive to basic and acidic media commonly required for the cleavage of standard linker systems. The advantages of the PTMSEL linker are demonstrated in the synthesis of glycopeptides from the liver intestine (LI)-cadherin and the mucin MUC1, bearing carbohydrate moieties such as N-linked chitobiose or O-linked sialyl-T(N)-residues. The synthesis of the…

Suspended particulate matter fluxes along with their associated metals, organic matter and carbonates in a coastal Mediterranean area affected by min…

2016

International audience; A study of suspended particulate matter (SPM) fluxes along with their associated metals, organic matter and carbonates, was conducted off the Mejerda River outlet in May 2011 and in March and July 2012 at depths of 10, 20 and 40 m using sediment traps. SPM fluxes are more significant near the Mejerda outlet, especially in winter, but dissipate further offshore. Normalization reveals that the Mejerda is a major source of Pb, Zn, Cd, Cu, Ni, and Co, all of which are the result of human activities. In contrast, Fe, Mn and N are of authigenic origin. The enrichment factor shows that Pb, Zn and especially Cd are the most highly polluting metals off the Mejerda outlet. Thi…

On the influence of curvature and torsion on turbulence in helically coiled pipes

2014

Turbulent flow and heat transfer in helically coiled pipes at Retau=400 was investigated by DNS using finite volume grids with up to 2.36×10E7 nodes. Two curvatures (0.1 and 0.3) and two torsions (0 and 0.3) were considered. The flow was fully developed hydrodynamically and thermally. The central discretization scheme was adopted for diffusion and advection terms, and the second order backward Euler scheme for time advancement. The grid spacing in wall units was ~3 radially, 7.5 circumferentially and 20 axially. The time step was equal to one viscous wall unit and simulations were typically protracted for 8000 time steps, the last 4000 of which were used to compute statistics. The results s…

Simulazioni Numeriche del Campo di Moto e della Caduta di Pressione in Tubi Elicoidali

2009

The southern Tyrrhenian Sea margin an example of lithospheric scale strike-slip duplex

2010

The southern Tyrrhenian Sea margin is dominated by deformations whose kinematics are relatively poorly constrained, and different models have been proposed to account for its recent evolution. Analysis of new structural and space geodesy data, combined with available geophysical information, reveal a deformation field characterised by subhorizontal NW-SE directed shortening and SW-NE directed extension. The main recognised regional-scale structure comprises E-W trending fault zones, namely the Ustica-Eolie Line and the Mt. Kumeta-Alcantara Line, connected by the NW-SE trending Marettimo, Trapani, San Vito, Palermo, Gratteri-Mt. Mufara and Eolie faults. This fault network displays a remarkab…