Search results for "PK"

European ADPKD Forum multidisciplinary position statement on autosomal dominant polycystic kidney disease care

2018

Autosomal dominant polycystic kidney disease (ADPKD) is a chronic, progressive condition characterized by the development and growth of cysts in the kidneys and other organs and by additional systemic manifestations. Individuals with ADPKD should have access to lifelong, multidisciplinary, specialist and patient-centred care involving: (i) a holistic and comprehensive assessment of the manifestations, complications, prognosis and impact of the disease (in physical, psychological and social terms) on the patient and their family; (ii) access to treatment to relieve symptoms, manage complications, preserve kidney function, lower the risk of cardiovascular disease and maintain quality of life;…

Darba nosaukums- 3-5 gadus vecu bērnu pašapkalpošanās prasmju pilnveide lomu rotaļās

2020

Kvalifikācijas darba temats: 3-5 gadus vecu bērnu pašapkalpošanās prasmju pilnveide lomu rotaļās. Darba autors: Madara Umbraško Kvalifikācijas darba mērķis: analizēt autoru atziņas par pašapkalpošanās prasmēm un pētīt to pilnveides iespējas 3 – 5 gadus veciem bērniem lomu rotaļās. Lai īstenotu mērķi un uzdevumus teorētiskajā daļā tika pētīta un analizēta psiholoģiskā un pedagoģiskā literatūra par pašapkalpošanās prasmēm un to nozīmi attīstībā, 3 – 5 gadus vecu bērnu attīstības raksturojums un lomu rotaļu nozīme pašapkalpošanās prasmju apguves veicināšanā. Empīriskajā daļā tika pētīta lomu rotaļu ietekme uz pašapkalpošanās prasmju apguvi. Veikta novērošana “X” izglītības iestādes jaukta vecu…

Mirar con cuidado. Filosofía y Escepticismo [Introducció]

1994

Presentación y descripción del plan del libro "Mirar con Cuidado. Filosofía y Escepticismo". Descripción de las participaciones en él incluidas y formulación de las tesis en ellas defendidas

Paroda Johann Christoph Brotze “Johano Kristofo Brocės (1742-1823) Livonijos piešinių ir aprašų kolekcija Latvijos universiteto Akademinėje bibliotek…

2018

Latvijas Vēstures Institūta Žurnāls. 2015, Nr. 3 (96)

2015

Valsts kultūrkapitāla fonds

The Center of Intercultural Dialogue of Academic Library of University of Latvia as a tool for developing Latvian-Georgian relations

2019

Metformin influences drug sensitivity in pancreatic cancer cells

2018

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes. Metformin acts in part by stimulating AMP-kinase (AMPK) and results in the suppression of mTORC1 activity and the induction o…

Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus

2019

Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. In fact, some of them are standard drugs used for treatment of T2D, such as biguanides and thiazoli-dindione…

AMPK regulates macrophage polarization in adipose tissue inflammation and NASH

2013

Molecular and Translational Medicine, Dept. of Medicine I, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrase 1,55116 Mainz, GermanyCOMMENTARY ON:Hematopoietic AMPK beta1 reduces mouse adipose tissue mac-rophage inflammation and insulin resistance in obesity. Galic S,Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Walkley CR,Izon D, Honeyman J, Chen ZP, van Denderen BJ, Kemp BE, Stein-berg GR. J Clin Invest 2011;121(12):4903–15. Copyright 2011.Reprinted with permission of American Society for ClinicalInvestigation.http://www.ncbi.nlm.nih.gov/pubmed/22080866Abstract: Individuals who are obese are frequently insulin resistant,putting them at increased risk of d…

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

2023

A diet rich in saturated fatty acids (FAs) has been correlated with metabolic dysfunction and ROS increase in the adipose tissue of obese subjects. Thus, reducing hypertrophy and oxidative stress in adipose tissue can represent a strategy to counteract obesity and obesity-related diseases. In this context, the present study showed how the peel and seed extracts of mango (Mangifera indica L.) reduced lipotoxicity induced by high doses of sodium palmitate (PA) in differentiated 3T3-L1 adipocytes. Mango peel (MPE) and mango seed (MSE) extracts significantly lowered PA-induced fat accumulation by reducing lipid droplet (LDs) and triacylglycerol (TAGs) content in adipocytes. We showed that MPE a…