Search results for "PLE"
showing 10 items of 22773 documents
Microchimerism in multiple sclerosis: The association between sex of offspring and MRI features in women with multiple sclerosis
2023
AimsDuring pregnancy, fetal cells can migrate to the mother via blood circulation. A percentage of these cells survive in maternal tissues for decades generating a population of fetal microchimeric cells (fMCs), whose biological role is unclear. The aim of this study was to investigate the association between the sex of offspring, an indirect marker of fMCs, and magnetic resonance imaging (MRI) features in women with multiple sclerosis (MS).MethodsWe recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to acquire 3D-T2w FLAIR FatSat and 3D-T1w FSPGR/TFE. Lesion Segmentation To…
Microchimerism and multiple sclerosis: a study on the impact of the sex of offspring on clinical, radiological, and paraclinical features of maternal…
2023
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder characterised by inflammation and neurodegeneration and representing one of the most common causes of neurologic disability among young adults. Over the last 40 years, several authors have confirmed the existence of fetal cells in maternal blood and their pregnancy-related origin, demonstrating that pregnancy may establish a long-term, low-grade chimeric state in women. The biological and clinical significance of fetal microchimeric cells (fMCs) in maternal health is largely unknown, although a role in autoimmune diseases have been hypothesised. Aims. The overarching aim of my PhD dissertation was to investigate the role o…
Sex-specific signatures of intrinsic hippocampal networks and regional integrity underlying cognitive status in multiple sclerosis
2021
Abstract The hippocampus is an anatomically compartmentalized structure embedded in highly wired networks that are essential for cognitive functions. The hippocampal vulnerability has been postulated in acute and chronic neuroinflammation in multiple sclerosis, while the patterns of occurring inflammation, neurodegeneration or compensation have not yet been described. Besides focal damage to hippocampal tissue, network disruption is an important contributor to cognitive decline in multiple sclerosis patients. We postulate sex-specific trajectories in hippocampal network reorganization and regional integrity and address their relationship to markers of neuroinflammation, cognitive/memory per…
Culture as an influence on sexting attitudes and behaviors: A differential analysis comparing adolescents from Spain and Colombia
2020
Abstract This study analyses the prevalence of sexting and the reasons and attitudes associated with its practice in adolescents with different cultural backgrounds (Colombia and Spain). The sample is made up of 489 Spaniards and 510 Colombians aged between 13 and 18 years. The results show that sexting is strongly influenced by gender and the country, in favor of men and Colombians respectively. The interaction between gender and country establishes that in Spain women and men practice sexting equally, while in Colombia men practice much more sexting than women. Although the practice of sexting increases progressively with age, the levels are higher among Colombian adolescents, especially …
Influence of sexual sensation seeking, sexual compulsivity and sexual pleasure in condom use among Spanish youth: implications for HIV interventions
2016
Spain is one of the countries with the highest incidence of HIV within the European Union. Multiple and complex factors influence HIV infection in young people. This study aims to determine the influence of sexual sensation seeking, sexual compulsivity and perceived sexual pleasure variables in condom use. A total of 424 heterosexual youth were evaluated (M age = 20.62; SD = 2.62) distributed into a risk group (60.7%) and a no-risk group (39.3%). Sexual Sensation Seeking Scale, AIDS Prevention Questionnaire, Sexual Compulsivity Scale, and Sexual Pleasure Perceived Scale were administered. Results indicate statistically significant differences in sexual sensation seeking (p=.001), failure to…
Storie di guerra. Sfollati, rimpatriati, profughi a Palermo (1940-1943)
2018
In the realm of wartime history, a little real analysis has been done on the implications of total war in Sicily. Indeed, World War II transformed the relationship between fascist regime and society. Moreover, there are few studies on reorganization of the connections between local institutions and fascist government. Civilians have been most involved in this process. In this article, I will mainly adopt the perspective of civilians to reconstruct how war led to these transformations. I will focus on the city of Palermo, were war front and home front blurred together in 1943. Especially, I would like to highlight the stories of returned from fascist colonies in Africa, as well as the issue …
Modeling of the Shear Connection Capacity of Hybrid Steel Trussed Composite Beams
2019
Hybrid Steel Trussed Composite Beams represent a technical solution in use in numerous countries since many years. They are able to join the advantages of prefabrication with those of cast in place structures: they are easy to manufacture, fast to realize, monolithic and with no need of formwork. The behavior of these beams has been recently topic of discussion in the scientific community because the knowledge both related to the reinforced concrete structures and that of composite constructions cannot be straightforwardly extended to this typology, which is intermediate between one and another technology. This paper provides a contribution towards a better understanding of the mechanism of…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
FIBRE OPTICAL COUPLER SIMULATION BY COMSOL MULTIPHYSICS SOFTWARE
2022
Funding: The research has been supported by the European Regional Development Fund project No.1.1.1.1/18/A/068. The Institute of Solid State Physics, University of Latvia as a Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2.
La corte del re di Napoli Ferrante I d'Aragona (1458-1494): tradizione e innovazioni
2015
In seguito alla conquista del regno di Napoli da parte di Alfonso il Magnanimo, la corte, stabilitasi nella capitale, mantenne la struttura ed il funzionamento previsti dalla tradizione aragonese codificata nelle ordinanze di Pietro il Cerimonioso. Sulla base di fonti documentarie recentemente venute alla luce e delle ultime acquisizioni storiografiche, il contributo pone in evidenza come Ferrante, erede del Magnanimo al trono napoletano, sebbene mantenne l’organizzazione palatina ereditata dal padre, per le sue tendenze accentratrici introdusse nell’amministrazione finanziaria centrale talune innovazioni funzionali, al fine di un più ampio controllo delle risorse e delle spese della corte,…