Search results for "PLLA"
showing 3 items of 33 documents
Polymeric scaffolds based on blends of poly-l-lactic acid (PLLA) with poly-d-l- lactic acid (PLA) prepared via thermally induced phase separation (TI…
2012
Porous scaffolds based on blends of high crystalline Poly-L-lactic acid (PLLA) with low crystalline poly-D-L-lactic acid (PLA) were prepared via Ther- mally Induced Phase Separation (TIPS), with the aim of exploring the possibility to control the degradation behaviour of the PLA-based scaffold, simultaneously pre- serving the morphological characteristics required for tissue engineering applica- tions. Porous foams with different PLLA/PLA weight ratios (from 95/5 to 60/40) were produced and characterised in terms of pore size, porosity, and thermal properties. The scaffolds present an open porosity, with average pore sizes ranging from 30 to 70 lm. Results showed that, when dealing with a P…
PLLA Scaffold via TIPS for Bone Tissue Engineering
2016
Tissue engineering offers a promising new approach to repair bone fractures, fractures that do not heal, and fractures due to bone tumors. In this work, two different approaches were tested in order to obtain Poly-L- Lactic Acid (PLLA) porous scaffolds via Thermally Induced Phase Separation (TIPS) for bone tissue engineering application. First, the possibility to produce a composite material, by incorporating Hydroxyapatite (HA) particles in a Poly-L-lactic acid (PLLA) matrix was investigated. Two PLLA/HA weight ratios (70/30 and 50/50) were tested. The results showed that the presence of HA does not influence the phase separation process, i.e. the composite scaffolds microstructure is simi…
A Continuous Pore Size Gradient PLLA Scaffold For Osteochondral Regeneration
2016
Osteochondral (OC) scaffold-based regenerative approaches in the joint are challenging since the scaffold must provide mechanical strength while also mimicking the local cartilage and bone microenvironments. Thermally Induced Phase Separation (TIPS) can produce scaffolds with a wide range of pore size morphologies/distributions. Here, we produced by TIPS a poly-L-lactide (PLL A) scaffold with a continuous pore size gradient along the sample thickness, from ~70μm diameter on one side to ~200 μm diameter on the opposite surface.