Search results for "PMN"
showing 10 items of 15 documents
The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated fr…
2016
It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NFκB-p65, TNFα and leukocyte-endothelium interactions. Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA…
Relationship between PMN-endothelium interactions, ROS production and Beclin-1 in type 2 diabetes.
2020
Type 2 diabetes is closely related to oxidative stress and cardiovascular diseases. In this study, we hypothesized that polymorphonuclear leukocytes (PMN)-endothelium interactions and autophagy are associated. We evaluated PMN-endothelial interactions, ROS production and autophagy parameters in 47 type 2 diabetic patients and 57 control subjects. PMNs from type 2 diabetic patients exhibited slower rolling velocity (p < 0.001), higher rolling flux (p < 0.001) and adhesion (p < 0.001) in parallel to higher levels of total (p < 0.05) and mitochondrial ROS (p < 0.05). When the protein expression of autophagy markers was analysed, an increase of Beclin-1 (p < 0.05), LC3I (p < 0.05), LC3II (p < 0…
EduBPMN: Un método Basado en Reglas de Transformación para Generar Interfaces Gráficas de Usuario a partir de Modelos de Procesos de Negocio (BPMN)
2020
El Modelo y Notación de Procesos de Negocios (BPMN) es un estándar desarrollado por la Object Management Group (OMG) que proporciona a las organizaciones la capacidad de comprender sus procedimientos empresariales internos en una notación gráfica. Los elementos básicos del modelo BPMN son eventos, flujo de secuencia, pool, carril, compuertas, subproceso, tareas, y otros elementos. El modelo BPMN no permite capturar el comportamiento funcional del sistema y la persistencia de los datos, siendo solo un modelo que brinda soporte al analista de negocio en el desarrollo de un sistema de información. El esfuerzo que realiza el analista de negocio en construir el modelo BPMN no se ve reflejado en …
Diagnostic performance of endoscopic ultrasound through‐the‐needle microforceps biopsy of pancreatic cystic lesions: Systematic review with meta‐anal…
2020
Objectives Endoscopic ultrasound through-the-needle biopsy (EUS-TTNB) is a useful tool for differential diagnosis among pancreatic cystic lesions (PCLs). Cystic fluid cytology (CFC) is recommended by guidelines, but its diagnostic accuracy is about 50%. The aim of this meta-analysis is to assess the clinical impact of EUS-TTNB in terms of technical success (TS), histological accuracy (HA) and diagnostic yield (DY). Methods Original studies in English language on EUS-TTNB were searched in MEDLINE and EMBASE until October 2019. Diagnostic accuracy of EUS-TTNB for identification of mucinous PCLs was calculated using individual diagnostic data of patients who underwent CFC and surgery. Results …
Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors
2022
Aims Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a recently recognized pancreatic tumor entity. Here we aimed to determine the most important features with a systematic review coupled with an integrated statistical approach. Methods and results PubMed, SCOPUS, and Embase were searched for studies reporting data on pancreatic ITPN. The clinicopathological, immunohistochemical, and molecular data were summarized. Then a comprehensive survival analysis and a comparative analysis of the molecular alterations of ITPN with those of pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) from reference cohorts (including the International Cance…
Non-Unitarity of the lepton mixing matrix at the European spallation source
2022
If neutrinos get mass through the exchange of lepton mediators, as in seesaw schemes, the neutrino appearance probabilities in oscillation experiments are modified due to effective nonunitarity of the lepton mixing matrix. This also leads to new CP phases and an ambiguity in underpinning the ''conventional'' phase of the three-neutrino paradigm. We study the CP sensitivities of various setups based at the European spallation source neutrino super-beam (ESSnuSB) experiment in the presence of nonunitarity. We also examine its potential in constraining the associated new physics parameters. Moreover, we show how the combination of DUNE and ESSnuSB can help further improve the sensitivities on …
Are requirements elicitation sessions influenced by participants' gender? An empirical experiment
2021
[EN] Context: Requirements elicitation is a crucial phase in the software development life cycle. During requirements elicitation sessions, requirements engineers capture software requirements, and motivate stakeholders to express needs and expected software functionalities. In this context, there is a lack of extensive empirical research reporting the extent to which elicitation sessions can be influenced by participants' gender. Objective: This paper presents our research endeavour to investigate requirements engineers' effort and elicited requirements' accuracy based on participants' gender. Method: We conducted an experiment in two rounds with a total of 59 students who played the role …
A Comprehensive Mechanism Reproducing the Mass and Mixing Parameters of Quarks and Leptons
2013
It is shown that if, from the starting point of a universal rank-one mass matrix long favored by phenomenologists, one adds the assumption that it rotates (changes its orientation in generation space) with changing scale, one can reproduce, in terms of only six real parameters, all the 16 mass ratios and mixing parameters of quarks and leptons. Of these 16 quantities so reproduced, 10 for which data exist for direct comparison (i.e. the CKM elements including the CP-violating phase, the angles theta(12), theta(13), theta(23) in nu-oscillation, and the masses m(c), m(mu), m(e)) agree well with experiment, mostly to within experimental errors; four others (m(s), m(u), m(d), m(nu 2)), the expe…
The Cabibbo angle as a universal seed for quark and lepton mixings
2015
A model-independent ansatz to describe lepton and quark mixing in a unified way is suggested based upon the Cabibbo angle. In our framework neutrinos mix in a "Bi-Large" fashion, while the charged leptons mix as the "down-type" quarks do. In addition to the standard Wolfenstein parameters (lambda, A) two other free parameters are needed to specify the physical lepton mixing matrix. Through this simple assumption one makes specific predictions for the atmospheric angle as well as leptonic CP violation in good agreement with current observations.
A Methodology for Graphical Modeling of Business Rules
2011
This work proposes a novel methodology based on the Business Process Modeling Notation (BPMN) standard capable of graphically modeling business rules. A set of new representation patterns allows business analysts to map processes described through BPMN into conditions and actions of business rules. Our approach exploits Domain Specific Language techniques in order to make the methodology independent from the programming language supported by the specific rule engine. Moreover, this work proposes a web graphical editor, instantiated on a specific sample scenario, where the selected rule engine is Drools, one of the most used open source products. The developed editor allows business analysts…