Search results for "POF"

Aktywność biologiczna a struktura elektronowa pochodnych 1,3,4- tiadiazoli

2017

Przedmiotem badania była próba znalezienia korelacji między aktywnością biologiczną i właściwościami elektronowymi układów opartych na pochodnych tiadiazolu. Aktywność biologiczna związku chemicznego związana jest z jego cechami fizykochemicznymi. Jednym z najbardziej użytecznych parametrów w przewidywaniu aktywności biologicznej danej substancji, a także prognozowaniu o jej aktywności toksycznej jest lipofilowość, która stanowi ważny dyskryptor wykorzystywany w projektowaniu nowych leków oraz w ocenie aktywności substancji leczniczych już istniejących na rynku farmaceutycznym.Poszukiwanie korelacji pomiędzy strukturą chemiczną związku i właściwościami a aktywnością biologiczną stanowi prze…

Human NCL Neuropathology

2015

AbstractThe neuronal ceroid lipofuscinoses (NCL) currently encompass fourteen genetically different forms, CLN1 to CLN14, but are all morphologically marked by loss of nerve cells, particularly in the cerebral and cerebellar cortices, and the cerebral and extracerebral formation of lipopigments. These lipopigments show distinct ultrastructural patterns, i.e., granular, curvilinear/rectilinear and fingerprint profiles. They contain−although to a different degree among the different CLN forms−subunit C of ATP synthase, saposins A and D, and beta-amyloid proteins. Extracerebral pathology, apart from lipopigment formation, which provides diagnostic information, is scant or non-existent. The ret…

Retinal ultrastructure of neuronal ceroid-lipofuscinosis in the Dalmatian dog

1985

Ultrastructural studies of the retinae in two NCL-affected Dalmatian dogs revealed ubiquitous accumulation of lipopigments in numerous cell types of the retina, the fine structure of which closely resembled that seen in NCL-affected English setters. Photoreceptors and other retinal cell types were largely intact. These findings show that the retinal involvement in NCL of our Dalmatian dogs is identical to that of NCL-affected English setters. It also shows that in canine NCL a severe retinopathy, regularly encountered in human childhood NCL, does not develop. Thus, the NCL of Dalmatian dogs —and English setters — represents a reliable model to study human NCL, but for human retinopathia pig…

Retina in various animal models of neuronal ceroid-lipofuscinosis

1992

The childhood forms of human neuronal ceroid-lipofuscinosis (NCL) are invariably associated with a severe progressive retinopathy which commences at the photoreceptor level morphologically and proceeds to a final loss of neuronal cells accompanied by severe gliosis. In respective spontaneous animal conditions of NCL, in English setters, Dalmatian dogs, and New Zealand sheep, retinal involvement is not commensurate although the retina does not seem to be completely unaffected. In canine NCL, there might be functional and electro-physiological impairment of retinal cells, but retinal atrophy is not obvious. In ovine NCL, the retina, apart from accumulating NCL-specific lipopigments within neu…

Impact of inoculation with the phytostimulatory PGPR Azospirillum lipoferum CRT1 on the genetic structure of the rhizobacterial community of field-gr…

2009

International audience; The phytostimulatory PGPR Azospirillum lipoferum CRT1 was inoculated to maize seeds and the impact on the genetic structure of the rhizobacterial community in the field was determined during maize growth by Automated Ribosomal Intergenic Spacer Analysis (ARISA) of rhizosphere DNA extracts. ARISA fingerprints could differ from one plant to the next as well as from one sampling to the next. Inoculation with strain CRT1 enhanced plant-to-plant variability of the ARISA fingerprints and caused a statistically significant shift in the composition of the indigenous rhizobacterial community at the first two samplings. This is the first study on the ecological impact of Azosp…

Variazioni dell'apofisi trasversa della settima vertebra cervicale: studio anatomo - radiologico su una popolazione >

1990

Gli autori hanno studiato le modificazioni morfologiche delle apofisi trasverse della settima vertebra cervicale. Sono state osservate principalmente due variazioni: la mega - apofisi trasversa e la costa cervicale. Gli autori hanno riscontrato una incidenza di variazioni notevolmente superiore rispetto a quanto riportato in letteratura, suppongono che ciò sia dovuto alla relativa > geografica e socio - economica ed ipotizzano una trasmissione genetica di tale variazione del tipo autosomico recessivo.

L’ADOLESCENTE CON IPOGONADISMO IPOGONADOTROPO: LA CENTRALITA’ DEL RUOLO DEL PEDIATRA

2009

La tutela assicurativa della responsabilità professionale

2010

The Authors conducted a fact-finding survey among the health operators in some Sicilian and calabrian hospitals, hèreby eitending it to include doctors in training - in light of D.Lgs. 368/99 - and heilth operatórs in the area o in consideration oflaw42|9.T\esurveywas'aimedatdeterminingthedegree ofawarenessofthetypeofinsurancecoveràgeand/orcontraclsandlnlicies(>, "claims made") signed by the respective services, as well as about the protection supplied to health operators by the same insurance contracts.

Factores desencadenantes del perjuicio de los simúlidos

2021

El incremento de los daños causados por los dípteros simúlidos, desde finales de la década de los 90, ha suscitado un interés especial en el estudio de este grupo de dípteros en nuestro país. Además de la importancia de los estudios faunísticos, para conocer las especies presentes en nuestros hábitats, resulta de interés conocer otros aspectos ligados a la incidencia de sus ataques tanto al ser humano como a las especies animales de interés veterinario. La revisión del estado actual de la familia Simuliidae en España ha permitido la confección del listado de las 52 especies presentes y sus mapas de distribución. Se han llevado a cabo estudios de eficacia de tratamientos biol…

2017

Background Percutaneous edge‐to‐edge mitral valve repair ( PMVR ) has become an established treatment option for mitral regurgitation in patients not eligible for surgical repair. Currently, most procedures are performed under general anesthesia ( GA ). An increasing number of centers, however, are performing the procedure under deep sedation ( DS ). Here, we compared patients undergoing PMVR with GA or DS . Methods and Results A total of 271 consecutive patients underwent PMVR at our institution between May 2014 and December 2016. Seventy‐two procedures were performed under GA and 199 procedures under DS . We observed that in the DS group, doses of propofol (743±228 mg for GA versus 369±2…