Search results for "POF"

Sedation During Neurocritical Care

2019

AbstractSedation is an essential therapeutic strategy in the care of neurocritical patients. Intravenous sedative agents are the most widely used, with promising alternatives (dexmedetomidine, ketamine, and volatile agents) to propofol and midazolam arising. Studies designed to evaluate superiority and avoid biases are required. A neurological awakening test is safe in most patients. Potential risks and benefits of limiting deep sedation and daily interruption of sedation in these patients remain unclear. The aim of this review was to report recent clinical evidence on sedation in this subgroup of patients, focusing on its effects on clinical prognosis.

Improved Sedation in Diagnostic and Therapeutic ERCP: Propofol is an Alternative to Midazolam

2000

Background and Study Aims: Adequate sedation of the patient is required for diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). The anesthetic propofol, with its shorter half-life, affording better control, offers an alternative to the benzodiazepine midazolam. The aim of this randomized, controlled, unblinded study was to compare prospectively the quality of sedation under propofol and midazolam in patients undergoing ERCP. Patients and Methods: A total of 80 patients were randomized to sedation with propofol alone (n=40) or midazolam alone (n = 40). Blood pressure, pulse, and oxygen saturation were measured. Midazolam was given by the endoscopist and titrated…

Hypofractionated postoperative helical tomotherapy in prostate cancer: a mono-institutional report of toxicity and clinical outcomes

2018

Francesco Cuccia,1,2 Gianluca Mortellaro,2 Vincenzo Serretta,3 Vito Valenti,1,2 Antonella Tripoli,1,2 Marina Gueci,1,2 Nicoletta Luca,1,2 Antonio Lo Casto,4 Giuseppe Ferrera2 1Radiation Oncology School, University of Palermo, Palermo, Italy; 2Radiation Oncology, ARNAS-Civico Hospital, Palermo, Italy; 3Section of Urology, Department of Surgical Oncological and Oral Science, University of Palermo, Palermo, Italy; 4Radiation Oncology School, Section of Radiological Sciences, DIBIMED, Università degli Studi di Palermo, Palermo, Italy Purpose: This is a mono-institutional study of acute and late toxicities and early biochemical control of a retrospective series of 75 prostate…

Intravenous propofol allows fast intubation in neonates and young infants undergoing major surgery

2019

Aim of the study: In selected surgical neonates and infants, the rapidity of induction and intubation may represent an important factor for their safety. Propofol is an anesthetic characterized by a rapid onset and fast recovery time that may reduce time of anesthetic induction and improve post-anesthetic outcome. The aim of this study was to evaluate the safety and efficacy of anesthesia induction in full-term neonates and young infants after propofol bolus administration.Methods: A retrospective case-control study including infants below 6 months of age, undergoing general anesthesia between 2011 and 2013, was carried out. Patients that received intravenous propofol bolus to induce anesth…

68 ga-dotatoc pet/ct follow up after single or hypofractionated gamma knife icon radiosurgery for meningioma patients

2021

68Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed 68Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative 68Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). …

Ārpusšūnu cirkulējošo nukleīnskābju izpēte hipofīzes adenomas pacientos

2019

Līdz šim literatūrā nav ziņojumu par ccfDNA un cirkulējošo miRNS izpēti HA pacientu plazmā. Darbā tika novērtēta iespējamība detektēt HA izcelsmes ccfDNA plazmā, veicot mērķētu NGS pozīcijās, kuras saturēja HA somatiskās mutācijas, un veikts pētījums par miRNS sastāva izmaiņu detektēšanu plazmā 24 stundas pēc HA rezekcijas. HA eksomos atklātās somatiskās mutācijas tikai detektētas septiņās no 16 pārbaudītajām pozīcijām ccfDNA amplikonos. Divās ccfDNA pozīcijās mutantā alēle bija vairāk nekā 2% no kopējā nolasījumu skaita, kas varētu liecināt par šo ccfDNA izcelsmi no HA. Piecās pozīcijās no diviem HA pacientiem mutantās alēles īpatsvars ccfDNA bija ap 50%, kaut gan šīs mutācijas netika kons…

Molekulārie mikroRNS faktori hipofīzes adenomas attīstībā

2021

Izmaiņas miRNS ekspresijā ir saistītas ar dažādu audzēju patoģenēzi, tāpēc tās ir iespējams izmantot kā biomarķierus. Lai pētītu, kādas miRNS ir saistītas ar hipofīzes adenomām (HA), darbā ar nākamās paaudzes sekvencēšanu (NGS) tika analizēts miRNS sastāvs 13 HA pacientu audos, kā arī analizēts cirkulējošo miRNS profils plazmā pirms un pēc HA rezekcijas operācijas 13 HA pacientos. Statistiski būtiskas (P < 0,05) miRNS sastāva izmaiņas asins plazmā 24 stundas pēc operācijas noteiktas piecām miRNS (hsa-miR-143-3p; hsa-miR-1290; hsa-miR-223-3p; hsa-miR-12136; hsa-miR-425-5p) un to izmaiņas pēc Log2 fold change bija robežās no 0,55 līdz 2,87. HA pacientu audos tika identificētas 70 statistiski …

Mielisairaalan varjoista : nostalgia ja melankolia mielisairaala-alueilla asuneiden lapsuusmuistoissa

2018

1940–1960-luvuilla suomalaisten mielisairaaloiden henkilökunta perheineen asui tyypillisesti sairaala-alueilla tarkoitusta varten rakennetuissa asunnoissa. Käytäntö toi mielisairaala-alueille myös henkilökunnan lapset. Analysoin artikkelissa mielisairaalan henkilökunnan lasten lapsuudenympäristöihinsä liittämiä tunnekokemuksia. Nyt jo aikuisten lasten muistelmat sävyttyvät paitsi nostalgisesta kaipuusta lapsuuden leikkipaikkoihin ja mielisairaalaelämän yhteisöllisyyteen, myös melankoliasta, joka liittyi yhteisön eristyneisyyteen ja siellä läsnä olevaan väkivallan ja kuoleman uhkaan. Keskeisiä käsitteitä analyysissa ovat nostalgian ja melankolian lisäksi topofilia ja topofobia eli paikkaan l…

Characterization of neuronal neroid lipofuscinosis phenotype in three different cell lines subjected to RNA interference

2008

Ipofisi

2012

Considerata l'elevata complessità anato-funzionale e le ridotte dimensioni delle strutture presenti nella regione sellare e ixuta-sellare, la parte introduttiva dell'intervento sarà obbligatoriamente dedicata a brevi richiami di fisiologia dell'asse ipotalamo-ipofisario, alla diagnostica di laboratorio (talvolta erroneamente considerata “di supporto” alla diagnostica per immagini) e all'anatomia radiologica; ciò consentirà di meglio comprendere la necessità di un assoluto rigore nei protocolli d'esame utilizzati per ottenere immagini di elevata affidabilità diagnostica. Sarà dato ampio spazio ai protocolli di studio e saranno discusse le principali indicazioni allo studio di tali dis…