Search results for "POINT"
showing 10 items of 4385 documents
One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy
2020
Background: Cataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance. Methods: This International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedul…
Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability …
2012
Background Although significant efforts have been made to improve ST-segment elevation myocardial infarction (STEMI) outcomes by reducing symptom-onset-to-reperfusion times, strategies to decrease the clinical impact of ischemic reperfusion injury have demonstrated limited success. Bendavia, an intravenously administered mitochondrial targeting peptide, has been shown to reduce myocardial infarct size and attenuate coronary no-reflow in experimental modelswhen given before reperfusion. Design The EMBRACE STEMI study is a phase 2a, randomized, double-blind, placebo-controlled trial enrolling 300 patients with a first-time anterior STEMI and an occluded proximal or mid–left anterior descendin…
Multicenter experience with the antegrade fenestration and reentry technique for chronic total occlusion recanalization
2020
Objectives We aimed to evaluate the efficacy and safety of antegrade fenestration and reentry (AFR) for chronic total occlusion (CTO) recanalization in a multicenter registry. Background Adoption of antegrade dissection/reentry (ADR) for CTO recanalization has been limited, and novel ADR techniques are needed. Methods AFR involves the balloon-induced creation of multiple fenestrations between the false and true lumen. A targeted true lumen reentry is subsequently achieved with a low tip-load polymer-jacketed guidewire. Following the initial description and dissemination of AFR, patients undergoing AFR-based CTO recanalization at nine centers were included in the present registry. Study endp…
Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Sin…
2021
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the rescue treatment proposed to patients with refractory cardiogenic shock. The VA-ECMO implantation promotes inflammation and ischemia-reperfusion injuries through the VA-ECMO flow, causing digestive mucosa barrier disrupture and inducing translocation of bacterial wall components—Lipopolysaccharides (LPS) with further inflammation and circulatory impairment. LPS is a well-studied surrogate indicator of bacterial translocation. Oxiris membrane is a promising and well-tolerated device that can specifically remove LPS. The main study aim is to compare the LPS elimination capacity of Oxiris membrane vs. a non-absorban…
Melting point, molecular symmetry and aggregation of tetrachlorobenzene isomers: the role of halogen bonding
2018
Tetrachlorobenzenes represent one of the best known, but not yet fully understood, group of isomers of the structure–melting point relationship. The differences in melting temperatures of these structurally related compounds were rationalized in terms of the hierarchy and nature of formed noncovalent interactions, and the molecular aggregation that is influenced by molecular symmetry. The highest melting point is associated with the highly symmetric 1,2,4,5-tetrachlorobenzene isomer. The structures of less symmetrical 1,2,3,4-tetrachlorobenzene and 1,2,3,5-tetrachlorobenzene, determined at 270 and 90 K, show a distinct pattern of halogen bonds, characterized by the different numbers and typ…
Shared socioeconomic pathways for climate change research in Finland: co-developing extended SSP narratives for agriculture
2021
AbstractShared socioeconomic pathways (SSPs), developed at global scale, comprise narrative descriptions and quantifications of future world developments that are intended for climate change scenario analysis. However, their extension to national and regional scales can be challenging. Here, we present SSP narratives co-developed with stakeholders for the agriculture and food sector in Finland. These are derived from intensive discussions at a workshop attended by approximately 39 participants offering a range of sectoral perspectives. Using general background descriptions of the SSPs for Europe, facilitated discussions were held in parallel for each of four SSPs reflecting very different c…
Zastosowanie metody BIPOLAR na przykładzie problemu wyboru dostawcy usług logistycznych
2018
Idea metody BIPOLAR polega na tym, że warianty decyzyjne nie są porównywane bezpośrednio ze sobą a z zestawami rozwiązań wskazanych jako referencyjne. Takie porównanie umożliwia sprawdzenie czy istnieją przesłanki do uznania danego wariantu za mający przewagę nad każdym z pozostałych. Zbiór rozwiązań nazywa się zbiorem punktów referencyjnych, który zawiera rozwiązania dobre i złe. Metoda BIPOLAR uwzględnia wszystkie etapy procesu decyzyjnego: wybór kryteriów oraz określenie ich wag, modelowanie preferencji decydentów, wybór właściwego wariantu decyzyjnego na podstawie rankingu.
On a min-max principle for non-smooth functions and applications
2009
Extensions of the seminal Ghoussoub's min-max principle [15] to non-smooth functionals given by a locally Lipschitz continuous term plus a convex, proper, lower semi-continuous function are presented and discussed in this survey paper. The problem of weakening the PalaisSmale compactness condition is also treated. Some abstract consequences as well as applications to elliptic hemivariational or variational-hemivariational inequalities are then pointed out. ©Dynamic Publishers, Inc.
A Dynamic Electrical Scheme for the optimal reconfiguration of PV modules under non-homogeneous solar irradiation
2012
This paper presents a strategy for the maximization of the output power of photovoltaic (PV) systems under non homogeneous solar irradiation by means of automatic reconfiguration of the PV arrays layout. The innovation of the proposed approach is the employment of a simple Dynamic Electrical Scheme (DES), allowing a large number of possible modules interconnection, to be installed between the PV generator and the inverter. The models of the PV generator and of the DES have been realized and simulated with Simulink (Dynamic System Simulation for MATLAB). The attained experimental results appear to be quite interesting in terms of the attainable benefit in power and thus energy terms. The lim…
La stima del crossing-point nel modello di Cox per l'analisi di sopravvivenza: una proposta
2008
La variazione dell'effetto di un fattore di rischio in un modello di sopravvivenza a rischi proporzionali di Cox è di particolare interesse in molte applicazioni, in quanto l'allontanamento dall'ipotesi di proporzionalità dei rischi rende il modello inadeguato. Di particolare interesse è il caso in cui le funzioni di rischio di due gruppi si intersecano, ovvero, più in generale, il coefficiente di regressione cambia segno dopo un istante temporale detto crossing-point. In questo lavoro si propone una procedura per la stima del crossing-point applicabile anche al caso di variabili quantitative, e si discutono tre diversi metodi per la corrispondente stima intervallare. L'approccio è illustra…