Search results for "POINT"
showing 10 items of 4385 documents
A semi-parametric stochastic generator for bivariate extreme events
2017
The analysis of multiple extreme values aims to describe the stochastic behaviour of observations in the joint upper tail of a distribution function. For instance, being able to simulate multivariate extreme events is convenient for end users who need a large number of random replications of extremes as input of a given complex system to test its sensitivity. The simulation of multivariate extremes is often based on the assumption that the dependence structure, the so-called extremal dependence function, is described by a specific parametric model. We propose a simulation method for sampling bivariate extremes, under the assumption that the extremal dependence function is semiparametric. Th…
Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular …
2012
Abstract Background and aims Metformin is the first-line therapy in type 2 diabetes. In patients inadequately controlled with metformin, the addition of a sulfonylurea or pioglitazone are equally plausible options to improve glycemic control. However, these drugs have profound differences in their mechanism of action, side effects, and impact on cardiovascular risk factors. A formal comparison of these two therapies in terms of cardiovascular morbidity and mortality is lacking. The TOSCA.IT study was designed to explore the effects of adding pioglitazone or a sulfonylurea on cardiovascular events in type 2 diabetic patients inadequately controlled with metformin. Methods Multicentre, random…
Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospe…
2019
Abstract Aims According to cardiovascular outcome trials, some sodium‐glucose contransporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real‐world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP‐1RA as second or a more advanced line of therapy. Materials and methods DARWIN‐T2D was a retrospective multi‐centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP‐1RA (exenatide once weekly or liraglutide). Data were c…
A novel flash glucose monitoring system in patients with diabetes mellitus type 1 and 2: which are the pieces of evidence for payer decision-makers?
2018
A rigorous health technology assessment is necessary to evaluate a new technology. However, healthcare regulatory agencies have less restrictive rules about medical devices, despite some recent warnings about this relevant matter. The evaluation should have at least two key issues, which require attention. The first one is its effectiveness, and the second one is its economic sustainability. In this paper, we deal with a novel glucose-sensing technology as a case study to examine the matter in depth. An evidence-based point of view is used to highlight this important issue.
Konsolidācija Aktīvu pārvaldīšanas nozarē un ietekme uz darbības procesiem
2018
Finanšu pakalpojumu vide neapšaubāmi ir ļoti mainīga un tuvākajos gados Aktīvu Pārvaldes nozarē būs nopietnas radikālās izmaiņas. Regulatori un tehnoloģijas attīstība veicina finansiālu sistēmu uz lielajām pārmaiņām. Pēdējos gados palielinājās ieguldījumu plūsma kompānijām, kas izmanto vienīgu apstrādes programmu, ar apkopoto datu analīzi. Tajā mākslīgais intelekts palīdz interpretēt finansiālo informāciju. Ar minētajām izmaiņām aktīvu pārvaldes dalībniekiem būs jāveido virkne jaunu analītisko rīku, jo cilvēki nebūs spējīgi apstrādāt visus datus patstāvīgi. Esošais cilvēka un mašīnas līdzsvars, turpinās noliekties vairāk un vairāk uz mašīnas pusēs, kamēr cilvēks gandrīz pilnīgi būs aizvieto…
The influence of non-verbal body language on sport performance in professional tennis
2019
The main objective of this study was to analyse the relationship between players´ non-verbal body language and their performance in sport. The sample consists of a total of 477 actions from 40 players competing in the ATP Tour. All actions were taken from tie-breaks in official tournaments. The categories that were analyzed were previous performance, dominant non-verbal body language, submissive non-verbal body language, and performance later on. Results show how the players´ non verbal body language impacts on their performance later on. Thus, we can conclude that following dominant non-verbal body language, the probabilities of better performance in the next point are greater than follow…
Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells
2017
AbstractHepatocellular carcinoma (HCC) is one of the common malignancies and is an increasingly important cause of cancer death worldwide. Surgery, chemotherapy, and radiation therapy extend the 5-year survival limit in HCC patients by only 6%. Therefore, there is a need to develop new therapeutic approaches for the treatment of this disease. The orally bioavailable proteasome inhibitor MLN2238 (ixazomib) has been demonstrated to have anticancer activity. In the present study, we investigated the preclinical therapeutic efficacy of MLN2238 in HCC cells through in vitro and in vivo models, and examined its molecular mechanisms of action. MLN2238 inhibited cell viability in human HCC cells He…
Oscillatory integrals and fractal dimension
2021
Theory of singularities has been closely related with the study of oscillatory integrals. More precisely, the study of critical points is closely related to the study of asymptotic of oscillatory integrals. In our work we investigate the fractal properties of a geometrical representation of oscillatory integrals. We are motivated by a geometrical representation of Fresnel integrals by a spiral called the clothoid, and the idea to produce a classification of singularities using fractal dimension. Fresnel integrals are a well known class of oscillatory integrals. We consider oscillatory integral $$ I(\tau)=\int_{; ; \mathbb{; ; R}; ; ^n}; ; e^{; ; i\tau f(x)}; ; \phi(x) dx, $$ for large value…
Target point calculation in the computerized tomography. Comparison of different stereotactic methods
1995
The adaptation of computerized tomography for stereotactic operations requires the transformation of the coordinates of the target point from the CT image space into the stereotactic frame space. Two basic solutions for this transformation are realized in the most of the contemporary stereotactical systems. The indirect geometric method adjusts the frame coordinate system mechanically and identifies its origin in the CT image. There are 6 degrees of freedom: 3 of rotation and 3 of translation which have to be taken into consideration. The second method is a based on direct algebraic coordinate transformation and is independent of the explicite knowledge of the relationship between the image…
Branding y personalidad de la marca visual
2021
La identidad visual proyecta una determinada personalidad de la marca, a través de sus elementos gráficos, espaciales y cromáticos. Este es el punto de partida para la construcción de la imagen de marca por parte del público. Sostenidos por la urdimbre del conocimiento transdisciplinar, se exploraron los nexos conceptuales, teóricos, metodológicosy técnicos, existentes entre los fundamentos de las técnicas proyectivas gráficas -propias de la psicología- y el diseñode marcas, a los efectos de definir la personalidad marcaria y el brand character, a partir de sus aspectos formales, espacialesy cromáticos.