Search results for "POLYASTARTAMIDE"

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Evaluation of the interaction and drug release from alpha,beta-polyaspartamide derivatives to a biomembrane model

2005

This article reports on a comparative study on the ability of various polymers, containing hydrophilic and/or hydrophobic groups, to interact with a biomembrane model using the differential scanning calorimetry (DSC) technique. Multilamellar vesicles of mixed dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidic acid (DMPA) were chosen as a model of cell membranes. The investigated samples were a water soluble polymer, the alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) and its derivatives partially functionalized with polyethylene glycol (PEG2000) to obtain PHEA-PEG2000, with hexadecylamine (C16) to obtain PHEA-C16, and with both compounds to obtain PHEA-PEG2000-C16. Th…

Materials sciencePolymersPharmaceutical SciencePolyethylene glycolGlycerophospholipidsMicellePolyethylene Glycolschemistry.chemical_compoundDifferential scanning calorimetryOrganic chemistryAminesMicelleschemistry.chemical_classificationDrug CarriersAniline CompoundsCalorimetry Differential ScanningPOLYASTARTAMIDE DRUG RELEASE BIOMEMBRANE MODELVesicleAnti-Inflammatory Agents Non-Steroidaltechnology industry and agricultureTemperatureBiological membraneMembranes ArtificialGeneral MedicinePolymerCombinatorial chemistryHydrocarbonsMembranechemistrySolubilityKetoprofenDrug deliverylipids (amino acids peptides and proteins)DimyristoylphosphatidylcholinePeptides

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