Search results for "POLYCAT"
showing 5 items of 15 documents
CCDC 164616: Experimental Crystal Structure Determination
2001
Related Article: G.De Munno, F.Cipriani, D.Armentano, M.Julve, J.A.Real|2001|New J.Chem.|25|1031|doi:10.1039/b102302k
Polycatenane systems from Co(II) and trans-1,2-bis(4-pyridyl)ethene (bpe). Synthesis and structure of Co(bpe)2(NCS)2·CH3OH, [Co(bpe)2(H2O)2](ClO4)2·2…
2001
Three new compounds of formulae Co(bpe)2(NCS)2·CH3OH, 1, [Co(bpe)2(H2O)2](ClO4)2·2CH3OH, 2 and [Co(bpe)2(H2O)2(CH3OH)2](ClO4)2·bpe·H2O, 3, [bpe = trans-1,2-bis(4-pyridyl)ethene] have been synthesised and characterised by single crystal X-ray diffraction. The metal environment in 1–3 is distorted octahedral. Compound 1 is a polycatenane. Its structure consists of parallel layers containing Co2+ ions linked by bpe ligands, the Co···Co distance through the bpe bridge being 13.65(3) A. Each metal ion, in a layer, defines the edges of a rhombus. Two thiocyanate groups trans-coordinated to the metal atoms are perpendicular to the sheets. Each sheet has an infinite number of perpendicular sheets …
Kinetic studies of the interaction between DNA and polycations based on polyasparthylhydrazide
2008
Abstract In the present paper, a systematic kinetic study on the interaction between interpolyelectrolytes such as positive-charged polymers and DNA was carried out. In particular, a qualitative–quantitative kinetic investigation on the interaction between copolymers of the α,β-poly(aspartylhydrazide) and DNA calf thymus filaments was performed. This study gives a new model starting from a well known “pseudo-phase model”, and permits to give a qualitative explanation about the trends of experimentally observed kinetic constants by varying the concentration of one of the two poly-electrolytes. Moreover, this study permits to verify the dependence of the binding constants KPAHy–CPTA and KDNA …
Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfection of CHO-K1 Cells.
2017
The introduction of the DNA into mammalian cells remains a challenge in gene delivery, particularly in vivo. Viral vectors are unmatched in their efficiency for gene delivery, but may trigger immune responses and cause severe side-reactions. Non-viral vectors are much less efficient. Recently, our group has suggested that a star-shaped structure improves and even transforms the gene delivery capability of synthetic polycations. In this contribution, this effect was systematically studied using a library of highly homogeneous, paramagnetic nano-star polycations with varied arm lengths and grafting densities. Gene delivery was conducted in CHO-K1 cells, using a plasmid encoding a green fluore…
Improvements in Rational Design Strategies of Inulin Derivative Polycation for siRNA Delivery.
2016
The advances of short interfering RNA (siRNA)-mediated therapy provide a powerful option for the treatment of many diseases, including cancer, by silencing the expression of targeted genes involved in the progression of the pathology. On this regard, a new pH-responsive polycation derived from inulin, Inulin-g-imidazole-g-diethylenetriamine (INU-IMI-DETA), was designed and employed to produce INU-IMI-DETA/siRNA "Inulin COmplex Nanoaggregates" (ICONs). The experimental results showed that INU-IMI-DETA exhibited strong cationic characteristics and high solubility in the pH range 3-5 and self-aggregation triggered by pH increase and physiological salt concentration. INU-IMI-DETA showed as well…