Search results for "POLYCYSTIC OVARY SYNDROME"

showing 10 items of 126 documents

Not all women diagnosed with PCOS share the same cardiovascular risk profiles

2009

Although definitive and confirmatory data are lacking, women with polycystic ovary syndrome (PCOS) are considered to be at increased risk for cardiovascular and metabolic disease. In recent years, the diagnosis of PCOS has broadened considerably to result in several phenotypes. Here we review the evidence for cardiovascular and metabolic risks in PCOS in the classic disorder and the various phenotypes. We conclude that not all women with PCOS should be considered as being similar in terms of cardiovascular risk profiles.

medicine.medical_specialtyPCOS cardiovascular risk hyperandrogenism insulin resistance metabolic syndrome lipid profileendocrine system diseasesRisk profileSettore MED/13 - EndocrinologiaMetabolic DiseasesRisk FactorsInternal medicinemedicineHumansCystMetabolic diseaseVascular diseasebusiness.industrynutritional and metabolic diseasesObstetrics and Gynecologymedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareSettore MED/40 - Ginecologia E OstetriciaPolycystic ovaryObesityfemale genital diseases and pregnancy complicationsPhenotypeEndocrinologyIncreased riskReproductive MedicineCardiovascular DiseasesMetabolomeFemaleMetabolic syndromeHyperandrogenismbusinessPolycystic Ovary SyndromeFertility and Sterility
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Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis.

2011

Objective To quantify the magnitude and pattern of low-density lipoprotein (LDL) cholesterol and nonhigh-density lipoprotein (HDL) cholesterol levels in women with polycystic ovary syndrome (PCOS) versus control women. Design Systematic review and meta-analysis of lipid levels in published cross-sectional studies worldwide where PCOS women and controls were examined and sampled. Main Outcome Measure(s) Differences in plasma lipids (including triglycerides, HDL-cholesterol, LDL-cholesterol, and nonHDL-cholesterol) in PCOS versus control subjects were calculated. Comparisons were made with and without body mass index (BMI) matching. Result(s) Triglyceride levels were 26 mg/dL (95% confidence …

medicine.medical_specialtySettore MED/13 - EndocrinologiaBody Mass Indexchemistry.chemical_compoundRisk FactorsMedicineHumansDyslipidemiasGynecologyTriglyceridebusiness.industryCholesterolHyperandrogenismnutritional and metabolic diseasesObstetrics and Gynecologymedicine.diseasePolycystic ovaryLipidsConfidence intervalReproductive MedicinechemistryPolycystic Ovary Syndrome dyslipidemia cardiovascular risklipids (amino acids peptides and proteins)FemalebusinessHyperandrogenismBody mass indexDyslipidemiaLipoproteinPolycystic Ovary SyndromeFertility and sterility
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Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the …

2010

Women with polycystic ovary syndrome (PCOS) often have cardiovascular disease (CVD) risk factors. The Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society created a panel to provide evidence-based reviews of studies assessing PCOS-CVD risk relationships and to develop guidelines for preventing CVD.An expert panel in PCOS and CVD reviewed literature and presented recommendations.Only studies comparing PCOS with control patients were included. All electronic databases were searched; reviews included individual studies/databases, systematic reviews, abstracts, and expert data. Articles were excluded if other hyperandrogenic disorders were not excluded, PCOS diagnosis was unclear, co…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismClinical BiochemistryMEDLINEDiseaseAndrogen ExcessRisk AssessmentBiochemistryBody Mass IndexEndocrinologyRisk FactorsDiabetes mellitusInternal medicineGlucose IntoleranceHumansMedicineWaist-Hip Ratiobusiness.industryBiochemistry (medical)nutritional and metabolic diseasesAtherosclerosismedicine.diseasePolycystic ovaryfemale genital diseases and pregnancy complicationsEndocrinologySystematic reviewDiabetes Mellitus Type 2Cardiovascular DiseasesFemaleRisk assessmentbusinessBody mass indexPolycystic Ovary SyndromeThe Journal of Clinical Endocrinology & Metabolism
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Insulin resistance and polycystic ovary syndrome.

2008

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in humans, affecting approximately 7-8% of women of reproductive age. Despite the criteria adopted, PCOS is considered to be a predominantly hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. Most women with PCOS also exhibit features of the metabolic syndrome, including insulin resistance, obesity and dyslipidaemia. While the association with type 2 diabetes is well established, whether the incidence of cardiovascular disease is increased in women with PCOS remains unclear. Acknowledging the strong impact of insulin-resistance in the genesis of PCOS co…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismMedicine (miscellaneous)Type 2 diabetesDiseaseEnvironmentBioinformaticsSettore MED/13 - EndocrinologiaInsulin resistanceRisk FactorsDiabetes mellitusInternal medicinemedicineHumansHypoglycemic AgentsGenetic Predisposition to DiseaseNutrition and Dieteticsbusiness.industryIncidenceHyperandrogenismnutritional and metabolic diseasesmedicine.diseasePolycystic ovaryObesityfemale genital diseases and pregnancy complicationsEndocrinologyDiabetes Mellitus Type 2Cardiovascular DiseasesFemaleInsulin resistance pcosMetabolic syndromeInsulin ResistanceCardiology and Cardiovascular MedicinebusinessPolycystic Ovary SyndromeNutrition, metabolism, and cardiovascular diseases : NMCD
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American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess And Pcos Society Disease State Clinical Rev…

2015

Polycystic Ovary Syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists (AACE) and the Androgen Excess and PCOS Society (AES) aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2015. PCOS has been defined using various criteria, including menstrual irregularity, hyperandrogenism, and polycystic ovary morphology (PCOM). General agreement exists among specialty society guidelines that the diagnosis of PCOS must be based on the presence o…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismType 2 diabetesAndrogen ExcessSeverity of Illness IndexLipoprotein particleFlutamideAnovulationImpaired glucose tolerancechemistry.chemical_compoundEndocrinologyInsulin resistancePregnancyInternal medicinemedicineHumansLife StylehirsutismMetabolic Syndromebusiness.industryHyperandrogenismnutritional and metabolic diseasesGeneral Medicinemedicine.diseasePolycystic ovaryPolycystic ovarian diseaseGestational diabetesEndocrinologyDiabetes Mellitus Type 2chemistryDisease ProgressionSpironolactoneFemaleInsulin ResistanceMetabolic syndromeHyperandrogenismbusinessInfertility FemaleAlgorithmsPolycystic Ovary SyndromeEndocrine Practice
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Mitochondrial complex I impairment in leukocytes from polycystic ovary syndrome patients with insulin resistance.

2009

Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial function.Our objective was to assess mitochondrial function by evaluating mitochondrial oxygen (O(2)) consumption, reactive oxygen species (ROS) production, levels of glutathione (GSH), the oxidized glutathione/GSH ratio, TNFalpha levels, and membrane potential. Additionally, we have evaluated mitochondrial complex I as a target of the oxidative stress responsible for PCOS in polymorphonuclear cells.This was a prospective controlled study conducted in an academic medical center.The study population consisted of 20 lean reproductive-age women with PCOS and 20 body composition-matched controls.…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryContext (language use)BiologyMitochondrionmedicine.disease_causeBiochemistrychemistry.chemical_compoundEndocrinologyInsulin resistanceOxygen ConsumptionInternal medicinemedicineLeukocytesHumanschemistry.chemical_classificationMembrane Potential MitochondrialReactive oxygen speciesElectron Transport Complex ITumor Necrosis Factor-alphaInsulinBiochemistry (medical)nutritional and metabolic diseasesGlutathionemedicine.diseasePolycystic ovaryGlutathionefemale genital diseases and pregnancy complicationsEndocrinologychemistryFemaleInsulin ResistanceReactive Oxygen SpeciesOxidative stressPolycystic Ovary Syndrome
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Glucose transporter 4 mRNA expression in subcutaneous adipose tissue of women with PCOS remains unchanged despite metformin withdrawal: is there a ce…

2021

Purpose: Metformin induces GLUT-4 mRNA expression in insulin target tissues in PCOS. It is unclear how long this impact is sustained after withdrawal of metformin. We aimed to compare the effect of metformin withdrawal on GLUT-4 mRNA expression in subcutaneous adipose tissue after prior short (ST, 1 year, N = 11) and long term (LT, at least 3 years, N = 13) treatment in obese PCOS women. Methods: At baseline and 6 months after withdrawal, biopsy of subcutaneous adipose tissue followed by quantitative PCR analysis was performed to determine GLUT-4 mRNA expression. Results: We found no time/effect differences in GLUT-4 mRNA expression in ST (2-dCt at baseline 0.42 (0.16–0.48) vs 2-dCt after 6…

medicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMrna expressionGlucose Transport Proteins FacilitativeSubcutaneous FatAdipose tissueQuantitative PCR analysisEndocrinologyInternal medicineBiopsymedicineHumansRNA MessengerAdipose tissue GLUT-4 mRNA Metformin PCOS Adipose Tissue Female Humans RNA Messenger Subcutaneous Fat Metformin Polycystic Ovary Syndromemedicine.diagnostic_testbusiness.industryInsulinGlucose transporternutritional and metabolic diseasesMetforminMetforminEndocrinologyAdipose TissueFemaleSubcutaneous adipose tissuebusinessPolycystic Ovary Syndromemedicine.drug
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Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters.

2005

In hyperandrogenic women, several phenotypes may be observed. This includes women with classic polycystic ovary syndrome (C-PCOS), those with ovulatory (OV) PCOS, and women with idiopathic hyperandrogenism (IHA), which occurs in women with normal ovaries. Where other causes have been excluded, we categorized 290 hyperandrogenic women who were seen consecutively for this complaint between 1993 and 2004 into these three subgroups. The aim was to compare the prevalence of obesity, insulin resistance, and dyslipidemia as well as increases in C-reactive protein and homocysteine in these different phenotypes with age-matched ovulatory controls of normal weight (n = 85) and others matched for body…

medicine.medical_specialtyendocrine system diseasesHomocysteineEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryBiochemistryBody Mass IndexNORMAL MENSESchemistry.chemical_compoundEndocrinologyInsulin resistanceRisk FactorsInternal medicineparasitic diseasesmedicineHumansInsulinANDROGEN EXCESSDEHYDROEPIANDROSTERONE SULFATEPLASMAbusiness.industryInsulinBiochemistry (medical)Hyperandrogenismnutritional and metabolic diseasesCholesterol LDLPOLYCYSTIC-OVARY-SYNDROMELuteinizing Hormonemedicine.diseaseObesityPolycystic ovaryfemale genital diseases and pregnancy complicationsEndocrinologyC-Reactive ProteinPhenotypechemistryCardiovascular DiseasesFemaleSENSITIVITYInsulin ResistancebusinessBody mass indexDyslipidemiaPolycystic Ovary SyndromeThe Journal of clinical endocrinology and metabolism
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The importance of diagnosing the Polycystic Ovary Syndrome

2000

The polycystic ovary syndrome (PCOS) is an extremely common disorder that occurs in 4% to 7% of women of reproductive age. Although PCOS is known to be associated with reproductive morbidity and increased risk for endometrial cancer, diagnosis is especially important because PCOS is now thought to increase metabolic and cardiovascular risks. These risks are strongly linked to insulin resistance and are compounded by the common occurrence of obesity, although insulin resistance and its associated risks are also present in nonobese women with PCOS. Women with PCOS are at increased risk for impaired glucose tolerance, type 2 diabetes mellitus, and hypertension. Cardiovascular disease is believ…

medicine.medical_specialtyendocrine system diseasesPhysiologyType 2 diabetesImpaired glucose toleranceInsulin resistanceDiabetes mellitusInternal medicineGlucose IntoleranceInternal MedicinemedicineHumansRisk factorbusiness.industryFibrinolysisnutritional and metabolic diseasesType 2 Diabetes MellitusGeneral Medicinemedicine.diseaseObesityPolycystic ovaryLipidsfemale genital diseases and pregnancy complicationsEndocrinologyCardiovascular DiseasesFemalepolycystic ovary syndrome cardiovascular risk insuline resistanceInsulin ResistancebusinessHyperandrogenismAnovulationPolycystic Ovary Syndrome
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DHEA, DHEAS and PCOS.

2014

Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g., patients with 21-hydroxylase deficient congenital classic or non-classic adrenal hyperplasia) demonstrate that APA excess can result in a PCOS-like phenotype. Inherited defects of the enzymes responsible for steroid biosynthesis, or defects in cortisol metabolism, account for only a very small fraction of women suffering from hyperandrogenism or APA excess. Rather, women wi…

medicine.medical_specialtyendocrine system diseasesmedicine.drug_classEndocrinology Diabetes and Metabolismmedicine.medical_treatmenteducationClinical BiochemistryPopulationSingle-nucleotide polymorphismSteroid biosynthesisBiochemistryBody Mass IndexEndocrinologyRisk FactorsInternal medicinemental disordersmedicinePrevalenceAnimalsHumanseducationMolecular Biologyeducation.field_of_studybusiness.industryDehydroepiandrosterone SulfateInsulinHyperandrogenismCell BiologyDehydroepiandrosteroneHyperplasiaAndrogenmedicine.diseaseObesityEndocrinologyPhenotypeCardiovascular DiseasesAndrogensMolecular MedicineFemaleSteroidsbusinessHyperandrogenismpsychological phenomena and processesPolycystic Ovary SyndromeThe Journal of steroid biochemistry and molecular biology
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