Search results for "POPULATION"

Towards a resilience management guideline — Cities as a starting point for societal resilience

2019

Unexpected crises and risks affect the urban population. Critical infrastructure dependency, climate change and social dynamics have captured the attention of city decision makers across different disciplines, sectors, and scales. Addressing these challenges mandates an increase in resilience. This article presents the development of the novel European Resilience Management Guideline (ERMG) developed by the European H2020 Smart Mature Resilience (SMR) project. It encompasses five supporting tools for city resilience. The purpose of this article is threefold. First, it describes the extensive co-creation methods used to establish, validate and test the five ERMG tools as collaborations among…

2021

Myoglobin (MB) is an oxygen-binding protein usually found in cardiac myocytes and skeletal muscle fibers. It may function as a temporary storage and transport protein for O2 but could also have scavenging capacity for reactive oxygen and nitrogen species. In addition, MB has recently been identified as a hallmark in luminal breast cancer and was shown to be robustly induced under hypoxia. Cellular responses to hypoxia are regulated by the transcription factor hypoxia-inducible factor (HIF). For exploring the function of MB in breast cancer, we employed the human cell line MDA-MB-468. Cells were grown in monolayer or as 3D multicellular spheroids, which mimic the in vivo avascular tumor arch…

Randomized multicenter comparison of two coatings of intramobile cylinder implants in 313 partially edentulous mandibles followed up for 5 years

2002

Intramobile cylinder (IMZ) implants with either of two coatings, hydroxyapatite (HA) or titanium plasma-flame (TPF), as distal abutments for combined tooth implant-supported restorations, were compared in 313 partially edentulous mandibles with respect to postprosthetical failure patterns and complication frequencies in a randomized multicenter clinical trial. Within the treatment protocols, the two coatings do not show evidence of different efficacy with respect to occurrence of postprosthetical integration deficiency (ID) or functional deficiency (FD). Statistical equivalence for an absolute effect of +/-15% in event-free survival could only be demonstrated for FD, not for ID, however. In…

Experiencias psicóticas atenuadas y consumo de cannabis en adolescentes de la población general

2019

El propósito de este estudio fue analizar la relación entre las experiencias psicóticas atenuadas y el consumo de cannabis en una muestra representativa de adolescentes de la población general. Un total de 1,588 estudiantes (M=16,13 años; DT = 1,36), 739 eran hombres (46,5%), pertenecientes a 34 escuelas y 98 aulas, seleccionados mediante muestreo aleatorio estratificado por conglomerados, fueron encuestados. Los instrumentos administrados fueron el Cuestionario de Pródromos de Psicosis-Breve, el Cuestionario de Capacidades y Dificultades, el Cuestionario de Consumo de Sustancias Modificado, el Penn Matrix Reasoning Test (PMRT), la Family Affluence Scale-II y la Escala Oviedo de Infrecuenci…

Schizophrenia polygenic risk score and cannabis use modify psychosis expression in first episode psychosis patients and population controls

2019

AbstractBackgroundDiagnostic categories within the psychosis spectrum are widely used in clinical practice, however psychosis may occur on a continuum. Therefore, we explored whether the continuous distribution of psychotic symptoms across categories is a function of genetic as well as environmental risk factors, such as polygenic risk scores (PRSs) and cannabis use.MethodsAs part of the EU-GEI study, we genotyped first episode psychosis patients (FEP) and population controls, for whom transdiagnostic dimensions of psychotic symptoms or experiences were generated using item response bi-factor modelling. Linear regression was used, separately in patients and controls, to test the association…

Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannab…

2015

Aim Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Question…

Cannabis and Psychosis: A Causal Association

2021

Nowadays, the use of cannabis is widespread around the world and THC content of confiscated cannabis has increased in the last years. This fact has raised some consequences, especially in the mental health of the people. Although there have existed some initial controversies about the relationship between cannabis and psychosis, at the present time there are some certainties of the causal association between them. Through the Bradford Hill postulates, we will try to demonstrate that cannabis produces psychosis. The strength of the association, the consistency along the studies, biological gradient, temporality, plausibility, coherence, experimentation, and analogies support the cause-effect…

The need for a behavioural science focus in research on mental health and mental disorders

2013

Psychology as a science offers an enormous diversity of theories, principles, and methodological approaches to understand mental health, abnormal functions and behaviours and mental disorders. A selected overview of the scope, current topics as well as strength and gaps in Psychological Science may help to depict the advances needed to inform future research agendas specifically on mental health and mental disorders. From an integrative psychological perspective, most maladaptive health behaviours and mental disorders can be conceptualized as the result of developmental dysfunctions of psychological functions and processes as well as neurobiological and genetic processes that interact with …

Administrative legitimacy and the democratic deficit of the European Union

2017

This article suggests a new concept of measurement for the EU’s oft-alleged democratic deficit based on two contributions. First, we turn attention to the administrative staff involved in policy-making rather than the (un)accountability of EUs’ parliamentarians and executive agents. Second, building on the idea that policy-makers’ legitimacy depends on the extent to which they can claim to represent some groups or social interests, we assess the extent to which Commission officials’ preferences reflect European citizens’ policy stance. Our results indicate a statistically significant positive correlation between the policy preferences of EU administrative staff and their home country popula…

Intermediaries: bridges across the digital divide

2012

The challenge of bringing developing countries into the “information society” has been traditionally framed as bridging the digital divide. Meeting this challenge has predominantly been through technical solutions aimed at providing physical access to the Internet. Yet, other aspects of the divide such as low literacy rates, gender and religious issues arguably pose bigger hurdles in getting the benefits of the Internet to the vast majority of the population of developing countries. They are seldom aware of the information available on the net and even when they are, they have difficulty using it. To facilitate access and use of the Internet by the population, an intermediary is often neede…