Search results for "PORP"
showing 10 items of 567 documents
Porphyrin tributyltin(IV) complexes for a novel approach in the tratment of human melanoma
2012
Melanoma is the most deadly form of skin cancer, largely refractory to existing therapies. The study of porphyrin derivatives as potential anti-tumor drugs has been an interesting field of investigation in the last years. Recently, a photo-independent cytotoxic effect of (Bu3Sn)4TPPS in the blocking melanoma cell proliferation an inducing a morphology cell change was investigated.[1] Amphiphilic CD (ACyD) provides more water soluble and adaptable nanovectors through modulation of the balance between hydrophobic and hydrophilic chains at both CD sides. ACyD can be conveniently tailored by covalently appending fluorescent label or receptor-targeting glycosyl- groups and can encapsulate conven…
"Dna binding of organotin(IV) complexes of meso-tetra (4 sulfonatophenyl) porphine showing cellular activity"
2016
Our research group has reported about the synthesis of alkynyl-substituted metallophthalocyanines of symmetric and unsymmetric nature. In this study, a novel phthalocyanine precursor bearing pyridin-3-ylethynyl groups and its tetrasubstituted metallo- phthalocyanines at peripheral positions were reported.
(Bu3Sn)4TPPS and (Bu2Sn)2TPPS significantly inhibit the growth, migrationand tumorigenicity of human malignant melanoma cells
2018
Melanoma is one of the most aggressive and treatment-resistant human cancers, it is responsible worldwide for the 80% of skin cancer related deaths which is largely due to its propensity to metastasize to other organs. The growing understanding of the pathways involved in melanoma progression and development has led to the identification of some interesting new molecules, however, the treatment options for metastatic melanoma remain limited. Indeed, the key step in metastasis development is the tumour cell invasion of the nearby host tissue and the journey powerfully depends on the detachment of single tumour cells from the primary tumour. Therefore, the ability to block the migratory and i…
LA PANCREATITE ACUTA: UNA TEMIBILE COMPLICANZA IN CORSO DI PORPORA DI HENOCHSCHONLEIN. CASISTICA DELLA CLINICA PEDIATRICA DI PALERMO
2018
Introduzione: La: porpora di Schönlein-Henoch (PSH) è la vasculite con più alta incidenza in età pediatrica. Le manifestazioni cliniche classiche sono: porpora palpabile, tumefazione articolare con artralgie, possibile dolore addominale con sangue occulto positivo o franca rettorragia, in casi con particolare severità, è possibile riscontrare addome acuto, insufficienza renale, proteinuria sino alla sindrome nefrosica. Rara è la pancreatite acuta che può rendere particolarmente drammatico il quadro clinico talvolta in modo irreversibile. La diagnosi viene confermata sia dal dosaggio di amilasi pancreatica, lipasi, sia dalla RMN addominale. La terapia prevede la somministrazione di steroidi …
La porpora di Seidlmayer: descrizione di cinque casi
2014
MANIFESTAZIONI ADDOMINALI E GONADICHE NELLA PORPORA DI SCHÖNLEIN-HENOCH: ESTRAPOLAZIONE DALLA CASISTICA DELLA CLINICA PEDIATRICA DI PALERMO
2011
NON SOLO PORPORA… SUCCESSO DELLA STRATEGIA TERAPEUTICA E NUTRIZIONALE
2018
La porpora di Schoenlein-Henoch (HSP) è la vasculite più comune in età pediatrica caratterizzata da depositi di immunocomplessi di IgA nei piccoli vasi. L’eziologia non è nota, ma è possibile una correlazione con infezioni batteriche, virus, alimentazione, punture di insetti e agenti fisici. La diagnosi è principalmente clinica. Le principali manifestazioni sono porpora cutanea, artrite, manifestazioni gastrointestinali e nefrite. Manifestazioni neurologiche e cardiache sono rare, come le localizzazioni polmonari e testicolari. Sporadicamente è descritto un coinvolgimento pancreatico. Riportiamo il caso di un bambino di 5 anni con HSP ad interessamento pluridistrettuale. B.G. giunge alla no…
Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas:…
2020
Background In the photodynamic therapy (PDT) of non‐aggressive basal cell carcinomas (BCCs), 5‐aminolevulinic acid nanoemulsion (BF‐200ALA) has shown non‐inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this is the first study using HAL‐PDT in the treatment of BCCs. Objectives To compare the histological clearance, tolerability (pain and post‐treatment reaction), and cosmetic outcome of MAL, BF‐200 ALA, and low‐concentration HAL in the PDT of non‐aggressive BCCs. Methods Ninety‐eight histologically verified non‐aggressive BCCs met the inclusion criter…
Neue Therapieoption für akute hepatische Porphyrien
2021
Was ist neu? Therapie mit Givosiran Givosiran ist ein kleines synthetisches doppelsträngiges siRNA-Fragment mit 20 Basenpaaren Länge. Eine prospektive, randomisierte multizentrische Studie (Envision) zeigte erstmalig die klinische Wirksamkeit von monatlich subkutan applizierten synthetischen RNA-Molekülen („small interfering“ RNA, siRNA) zur Prävention von Attacken bei akuten hepatischen Porphyrien (AHP) 2. Die Koppelung von siRNA-Molekülen an N-Acetyl-Galaktosamin (GalNAc) und die hierdurch leberspezifische Aufnahme durch den Asialoglykoprotein-Rezeptor auf Hepatozyten sind ein Meilenstein in der Hepatologie. Dies führt zu einer hochselektiven Inhibition der Translation der bei AHP überexp…
CCDC 1904437: Experimental Crystal Structure Determination
2019
Related Article: Marina V. Volostnykh, Sergey M. Borisov, Mikhail A. Konovalov, Anna A. Sinelshchikova, Yulia G. Gorbunova, Aslan Yu. Tsivadze, Michel Meyer, Christine Stern, Alla Bessmertnykh-Lemeune|2019|Dalton Trans.|48|8882|doi:10.1039/C9DT01577A