Search results for "POTENT"
showing 10 items of 3940 documents
Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived …
1998
Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines stimulate the production of α1-proteinase inhibitor (α1-PI) in hepatocyte-derived cells, only OSM is able to up-regulate levels of this inhibitor in epithelial cells originating from the lung. In this study we characterized human lung-derived epithelial-like HTB58 cells for their ability to synthesize α1-PI after treatment with IL-6, OSM and LIF. The results demonstrate that the resistance of HTB58 cells to the effects of IL-6 and LIF was not becau…
Unilateral Conditioning Contractions Enhance Power Output in Elite Short Track Speed Skaters
2018
AbstractThe objective of the present study was to assess the effect of unilateral lower-body-conditioning muscle contractions during multiple sets of fatiguing repeated jumps in elite athletes. Five elite short-track speed-skating athletes performed 9 sets of 6 maximal consecutive jumps on 2 separate occasions: with (COND) and without (CTRL) preliminary voluntary conditioning contractions (CC) 5 min before the beginning of the sets. The CC consisted of 2 consecutive 3 s maximal unilateral isometric squats against a fixed bar, resulting in a 6 s overall isometric contraction per leg. For each set, power output (PO) was measured using a linear position transducer and averaged over the 6 corre…
Brainstem Auditory Evoked Potentials and Visual Potentials in Kawasaki Disease: An Observational Monocentric Study
2020
Background: Kawasaki Disease is a systemic vasculitis, particularly involving coronary arteries. Rare involvement of other vascular districts is described, as central nervous system arteries, leading to a vasculitic neuropathy. Sensorineural hearing loss and alterations of evoked potentials are uncommonly reported complications.Methods: In an observational monocentric study, 59 children (37 males; 22 females; mean age: 2.7 ± 2.2 years) with documented Kawasaki Disease were enrolled. No risk factors for hearing loss and/or neurological impairment were identified in the cohort. Brainstem auditory evoked potentials and visual evoked potentials were correlated with clinical, hamatological and r…
Visual mismatch negativity for changes in orientation - a sensory memory-dependent response
2008
It remains unclear whether the mismatch negativity of event-related potentials (ERPs) in vision resembles its auditory counterpart in terms of memory relatedness. We recorded ERPs to visual bars in adult humans engaged in an auditory task. In one condition, a bar ('standard') repeated at 400- or 1100-ms non-stimulated intervals was rarely (P = 0.1) replaced by another bar of a different orientation ('deviant'). In the other condition (400-ms intervals), the occurrences of the standards were replaced by 10 (P = 0.1 each) bars of different orientations, including that of the deviant ('control-deviant'). Deviants shifted ERPs towards negative polarity relative to standards in occipital electro…
The electrofunctional investigations in the diagnosis of orbital diseases
1983
The importance of electrofunctional examinations (electroretinography, electro-oculography and visual evoked potentials) in orbital diseases is emphasized. Although such tests cannot give the same support to the clinical diagnosis as ultrasonography or CT scanning, they do give information about the functional state of the various orbital components. Visual evoked potentials can monitor the functionality of the optic nerve during and after trauma or compressive orbital diseases; electroretinography shows retinal changes secondary to traumatic or vascular orbital diseases, while electro-oculography allows to record extraocular muscle dysfunction.
Mapping of the human visual cortex using image-guided transcranial magnetic stimulation
2002
We describe a protocol using transcranial magnetic stimulation (TMS) to systematically map the visual sensations induced by focal and non-invasive stimulation of the human occipital cortex. TMS is applied with a figure of eight coil to 28 positions arranged in a 2x2-cm grid over the occipital area. A digitizing tablet connected to a PC computer running customized software, and audio and video recording are used for detailed and accurate data collection and analysis of evoked phosphenes. A frameless image-guided neuronavigational device is used to describe the position of the actual sites of the stimulation coils relative to the cortical surface. Our results show that TMS is able to elicit p…
Frailty and risk of complications in head and neck oncologic surgery. Systematic review and dose-response meta-analysis
2021
Background There is emerging evidence that frail individuals present a decreased physiological reserve, decreased ability to maintain homeostasis, and increased vulnerability to stressors. The concept of frailty has become increasingly recognized as a valuable measure in oncological surgical patients, including those with head and neck cancer. Preoperative screening for frailty may provide an individualized risk assessment that can be used by an interdisciplinary team for preoperative counseling and to improve outcomes. The aim of this meta-analysis was to evaluate the relationship between frailty and the risk of major postoperative complications in frail individuals submitted to head and n…
Quantifying Intermodal Distraction by Emotion During Math Performance: An Electrophysiological Approach
2019
Emotionally engaging stimuli are powerful competitors for limited attention capacity. In the cognitive neuroscience laboratory, the presence of task-irrelevant emotionally arousing visual distractors prompts decreased performance and attenuated brain responses measured in concurrent visual tasks. The extent to which distraction effects occur across different sensory modalities is not yet established, however. Here, we examined the extent and time course of competition between a naturalistic distractor sound and a visual task stimulus, using dense-array electroencephalography (EEG) recordings from 20 college students. Steady-state visual evoked potentials (ssVEPs) were quantified from EEG, e…
Associations between depression and specific childhood experiences of abuse and neglect: a meta-analysis
2015
Background\ud Research documents a strong relationship between childhood maltreatment and depression. However, only few studies have examined the specific effects of various types of childhood abuse/neglect on depression. This meta-analysis estimated the associations between depression and different types of childhood maltreatment (antipathy, neglect, physical abuse, sexual abuse, and psychological abuse) assessed with the same measure, the Childhood Experience of Care and Abuse (CECA) interview.\ud \ud Method\ud A systematic search in scientific databases included use of CECA interview and strict clinical assessment for major depression as criteria. Our meta-analysis utilized Cohen's d and…
Dissociable Effects of Reward on P300 and EEG Spectra Under Conditions of High vs. Low Vigilance During a Selective Visual Attention Task
2020
The influence of motivation on selective visual attention in states of high vs. low vigilance is poorly understood. To explore the possible differences in the influence of motivation on behavioral performance and neural activity in high and low vigilance levels, we conducted a prolonged 2 h 20 min flanker task and provided monetary rewards during the 20- to 40- and 100- to 120-min intervals of task performance. Both the behavioral and electrophysiological measures were modulated by prolonged task engagement. Moreover, the effect of reward was different in high vs. low vigilance states. The monetary reward increased accuracy and decreased the reaction time (RT) and number of omitted response…