Search results for "PPAR"
showing 10 items of 1686 documents
Biomarkers in obstructive respiratory diseases: An update
2012
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, with the involvement of many inflammatory cells and mediators. Traditionally, this inflammation is thought to spread to a systemic level, thus inducing damage of different organs. However, other pathogenetic mechanisms could take part to the above-described process, and some open questions need to be solved. Due to the burden and increasing prevalence of COPD, the opportunity to find biomarkers that can potentially be useful in identifying individuals with the disease, or better, prior to symptoms onset, to diagnose and properly manage the respiratory symptoms, as well as to evaluate the re…
Percutaneous Coronary Revascularization for Chronic Total Occlusions A Novel Predictive Score of Technical Failure Using Advanced Technologies
2016
Objectives The aims of this study were to describe the 10-year experience of a single operator dedicated to chronic total occlusion (CTO) and to establish a model for predicting technical failure. Background During the last decade, the interest in percutaneous coronary interventions (PCIs) of chronic total occlusions (CTOs) has increased, allowing the improvement of success rate. Methods One thousand nineteen patients with CTO underwent 1,073 CTO procedures performed by a single CTO-dedicated operator. The study population was subdivided into 2 groups by time period: period 1 (January 2005 to December 2009, n = 378) and period 2 (January 2010 to December 2014, n = 641). Observations were ra…
Cigarette smoke increases TLR4 and modifies LPS mediated responses in airway epithelial cells.
2008
Airway epithelium is emerging as a regulator of innate immune responses to a variety of insults including cigarette smoke. The main goal of this study was to explore the effects of cigarette smoke extracts (CSE) on Tolllike receptor (TLR) expression and activation in a human bronchial epithelial cell line (16-HBE). The CSE increased the expression of TLR4 and the lipopolysaccharide (LPS) binding, the nuclear factor-jB (NF-jB) activation, the release of interleukin-8 (IL-8) and the chemotactic activity toward neutrophils. It did not induce TLR2 expression or extracellular signal-regulated signal kinase 1/2 (ERK1/2) activation. The LPS increased the expression of TLR4 and induced both NF-jB a…
Comparison of global visual field indices (MD,VFI), GPA II change and cluster analysis of visual field progression in glaucoma
2014
Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
2021
Background and Objectives: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. Materials and Methods: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. Results: …
Minori migranti e la "famiglia mancante". Riflessioni di educazione interculturale.
2016
Sotto il profilo pedagogico, di consistente interesse risulta il titolo v del Decreto legislativo 286/1998 (la cosiddetta legge Turco-Napolitano), il “Diritto all’unità familiare e tutela dei minori”, nonché all’assistenza sanitaria e sociale, all’educazione ed alla prima e seconda accoglienza dei minori. Se da una parte giova constatare il carattere innovativo e aperto di questa legge, nonostante le molteplici difficoltà sul piano applicativo, dall’altra parte notiamo come poca importanza viene attribuita alla sfera familiare e affettiva per quei minori stranieri che rientrano nella categoria dei cosiddetti “non accompagnati” e cioè quei «minori stranieri che giungono nel territorio degli …
Concorso apparente di reati e istanze di ne bis in idem sostanziale
2022
In questo volume si analizzano le implicazioni sulla questione del concorso apparente di reati, delle decisioni degli ultimi anni della Corte EDU e della Corte di Giustizia dell’UE, relative al principio di ne bis in idem tra illeciti (sostanzialmente) penali (pur se formalmente amministrativi). In tal senso, nel primo capitolo ci si sofferma sul problema della distinzione tra concorso formale e apparente di reati dal codice Zanardelli a oggi. Nel secondo capitolo si esamina la giurisprudenza assai copiosa delle Sezioni Unite della Cassazione sul concorso apparente di reati, sia nelle enunciazioni teoriche sia nelle scelte concrete, per verificare quali criteri, al di là delle affermazioni …
Remodeled ostial atherosclerotic plaque in a single coronary artery demonstrated by computed tomography coronary angiography
2015
Erratum to: Safety Considerations of Inhaled Corticosteroids in the Elderly(Drugs Aging, (2014), 31, 7987-796, DOI 10.1007/s40266-014-0213-1)
2015
Inhaled corticosteroids (ICSs) are widely used in the treatment of patients with chronic obstructive pulmonary diseases. However, high-dose regimens and long-term use of ICSs have the potential to cause a variety of local and systemic side effects such as candidiasis, cataracts, glaucoma, and osteoporosis. The use of ICSs can also be associated with the risk of bone fractures, diabetes mellitus and pneumonia. These ICS-related side effects are of particular importance in elderly patients due to the presence of comorbidities and age-related behavioral, cognitive, and psychological problems, which can all interact with inhaled treatment. We reviewed the available literature on the clinically …