Search results for "PPAR"
showing 10 items of 1686 documents
Clinical implications of airway hyper-responsiveness in COPD
2006
COPD represents one of the leading causes of mortality in the general population. This study aimed at evaluating the relationship between airway hyperresponsiveness (AHR) and COPD and its relevance for clinical practice. We performed a MEDLINE search that yielded a total of 1919 articles. Eligible studies were defined as articles that addressed specific aspects of AHR in COPD, such as prevalence, pathogenesis, or prognosis. AHR appears to be present in at least one out of two individuals with COPD. The occurrence of AHR in COPD is influenced by multiple mechanisms, among which impairment of factors that oppose airway narrowing plays an important role. The main determinants of AHR are reduct…
Il trattamento domiciliare della TVP
2008
Occupational therapy, degree of disability and quality of life in COPD inpatients undergoing pulmonary rehabilitation programs
2010
Efecto de la activación del receptor PPARγ/RxR como posible tratamiento de la Enfermedad de Alzheimer. Papel de la genisteína
2020
La enfermedad de Alzheimer (EA) es una forma de demencia que empeora gradualmente con el tiempo y afecta de forma negativa a las funciones cognitivas. El tratamiento actual consiste en inhibidores de la acetilcolinesterasa y un antagonista NMDA. A pesar de que nunca hasta ahora se había dispuesto de un arsenal terapéutico en investigación tan amplio y variado frente a la EA, no se puede decir que sea efectivo. La enfermedad de Alzheimer conlleva un enorme gasto sanitario y social que se agrava con el envejecimiento de la población y el aumento de la prevalencia que este conlleva. En la presente tesis nos planteamos la administración de genisteína en fases iniciales de la enfermedad, buscand…
Nanochlorum eucaryotum — a green enigmatic alga: morphology, biochemistry and molecular biology
1994
In search of a natural systematic locality for algae — and also for other organisms — quite regularly the central question of evolution comes up. This proves as especially pertinent, when the taxonomic position of the most original phytoflagellates has to be considered. In the classical view of the direct filiation theory the ancestral phytoflagellata is positioned at the verge of the prokaryotic to the eukaryotic stage.
Environmental Conditions, Air Pollutants, and Airways
2019
Air pollution is a major problem worldwide, which could be even more serious for athletes who train in urban environments. Exercise increases minute ventilation and exposure to pollutants, but the literature on the effects of air pollution in athletes is relatively scarce, with the exception of chlorine exposure in athletes of aquatic sports and air pollution secondary to ice resurfacing in athletes performing in ice arenas. Although air pollution may exert detrimental effects on athletic performance, little has been published on this topic. The largest body of information regards the impact of air pollution during urban active transport, i.e., walking and cycling in cities, due to the pote…
Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options
2010
Asthma is a chronic inflammatory disorder of the airways that requires long-term treatment, the goal of which is to control clinical symptoms for extended periods with the least possible amount of drugs. International guidelines recommend the addition of an inhaled long-acting beta2-agonist (LABA) to a low- to medium-dose inhaled corticosteroid (ICS) when low doses of ICS fail to control asthma symptoms. The fixed combined administration of ICS/LABA improves patient compliance, reducing the risk of therapy discontinuation. The relative deposition pattern of the inhaled drug to the target site is the result of a complex interaction between the device used, the aerosol formulation and the pat…
Deep inspiration-induced changes in lung volume decrease with severity of asthma
2007
Summary We have previously reported that the magnitude of deep inspiration (DI)-induced bronchodilation is only slightly reduced in mild asthmatics, compared to healthy subjects. The aim of this study was to evaluate whether increased severity of asthma is associated with impairment in the ability of DI to induce changes in lung volume. Thirty-six consecutive asthmatics recruited from the Pulmonary and the Allergy Outpatient Clinics of the Institute of Respiratory Diseases of the University of Palermo were divided into 3 groups: Intermittent (I), Mild Persistent (MP) and Moderate–Severe (MS), based on GINA guidelines. Single dose methacholine (Mch) bronchoprovocations were performed in the …
Nutritional Status in Aging and Lung Disease
2016
Abstract Lung diseases exert a negative impact on nutritional status, especially among older patients where aging per se is already associated with relevant changes in nutrient intake, metabolism, and body composition. Both respiratory (increased respiratory work, hypoxia, and local oxidative stress and inflammation) and nonrespiratory (sarcopenia, reduced mitochondrial biogenesis and anabolic hormones, balance of orexigenic/anorexigenic neuropeptides, and systemic inflammation and oxidative stress) contribute to the association between lung diseases and malnutrition. For these reasons, nutritional assessments are of paramount importance in older patients with lung diseases. Current evidenc…