Search results for "PPAR"
showing 10 items of 1686 documents
Functional Inactivation of pRB Results in Aneuploid Mammalian Cells After Release From a Mitotic Block
2002
AbstractThe widespread chromosome instability observed in tumors and in early stage carcinomas suggests that aneuploidy could be a prerequisite for cellular transformation and tumor initiation. Defects in tumor suppressers and genes that are part of mitotic checkpoints are likely candidates for the aneuploid phenotype. By using flow cytometric, cytogenetic, immunocytochemistry techniques we investigated whether pRB deficiency could drive perpetual aneuploidy in normal human and mouse fibroblasts after mitotic checkpoint challenge by microtubule-destabilizing drugs. Both mouse and human pRB-deficient primary fibroblasts resulted, upon release from a mitotic block, in proliferating aneuploid …
Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA coho…
2018
The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analyse…
Tripotential data processing for HES interpretation
1994
In this paper some methods are proposed and compared to correct the experimental measurements for preliminary processing of tripotential data which are acquired for HES prospecting. However, the use of those methods should be based upon an accurate analysis of all experimental data. Such an analysis ought to involve: 1) an estimate of the averaged measurement errors with their variance and distribution in both the space and the three apparent-resistivities domains; 2) the choice of a resistivity model capable of describing the actual volume under study. The differences among the three values of apparent resistivity measured on a point are generally influenced both by the resistivity distrib…
'Naughty cylinder' mechanical paradox
2013
The double cone: a mechanical paradox or a geometrical constraint?
2011
In the framework of the Italian National Plan ‘Lauree Scientifiche’ (PLS) in collaboration with secondary schools, we have investigated the mechanical paradox of the double cone. We have calculated the geometric condition for obtaining an upward movement. Based on this result, we have built a mechanical model with a double cone made of aluminum and a couple of wooden rails.
A didactic experiment and model of a flat-plate solar collector
2011
We report on an experiment performed with a home-made flat-plate solar collector, carried out together with high-school students. To explain the experimental results, we propose a model that describes the heating process of the solar collector. The model accounts quantitatively for the experimental data. We suggest that solar-energy topics should be included in school programmes to give students the opportunity to gain experience with solar energy and increase their awareness of the benefits that can be obtained from this remarkable and renewable energy source.
TAPPARELLA AVVOLGIBILE A SISTEMA DESMODROMICO
2017
La presente invenzione riguarda una tapparella avvolgibile a sistema desmodromico. La tapparella della presente invenzione è dotata di un meccanismo che consente l'apertura delle lamelle sfruttando il peso stesso della tapparella. L'apertura delle lamelle viene attuata grazie alla particolare geometria del meccanismo e mediante l'interazione tra le guide e le parti scorrevoli della tapparella. La sua geometria riesce a determinare l’apertura o la chiusura delle lamelle. The present invention relates to a roller shutter with a desmodromic-system. The shutter of the present invention is provided with a mechanism allowing the slats to be opened by exploiting the weight of the blind itself. The…
The Narrative Medicine Approach in the Treatment of Diabetic Macular Edema: An Italian Experience.
2022
The study retraces the healthcare pathway of patients affected by diabetic macular edema (DME) through the direct voice of patients and caregivers by using a “patient journey” and narrative method approach. The mapping of the patient’s journey was developed by a multidisciplinary board of health professionals and involved four Italian retina centers. DME patients on intravitreal injection therapy and caregivers were interviewed according to the narrative medicine approach. Narratives were analyzed through a quali-quantitative tool, as set by the narrative medicine method. The study involved four specialized retina centers in Italy and collected a total of 106 narratives, 8…
Methods to investigate coronary microvascular function in clinical practice.
2012
A growing amount of data is increasingly showing the relevance of coronary microvascular dysfunction (CMVD) in several clinical contexts. This article reviews techniques and clinical investigations of the main noninvasive and invasive methods proposed to study coronary microcirculation and to identify CMVD in the presence of normal coronary arteries, also trying to provide indications for their application in clinical practice.
takotsubo cardiomiopathy after acute diarrhea
2010
Takotsubo cardiomyopaty is a recently described syndrome characterized by transient left ventricular dysfunction, mimicking an acute coronary syndrome and usually precipitated by a physical or emotional stress. We report the first case of Takotsubo cardiomyopathy after acute diarrhea in a man. It may be argued that severe diarrhea in predisposed individuals may cause an acute stress resulting in increased sympathetic activity leading to this syndrome. Probably the relationship between the adrenergic system and the heart is more complex than general thought and the stimuli which favor an autonomic imbalance and precipitate the syndrome are very disparate in clinical practice.