Search results for "PPAR"

An Inquiry Based Approach to the study of energy exchange by thermal radiation

2012

A teaching-learning sequence regarding the investigation of energy exchange by thermal radiation, conduction and convection is under development within the context of “Establish”, a FP7 European Project aimed at promoting and developing Inquiry Based Science Education in European Secondary Schools. Here we present some relevant laboratory activities of this inquiry-oriented teaching/learning sequence for secondary school level students (or even first-level university ones), aimed at investigating the physics of energy transmission by thermal radiation. In traditional laboratory work, the focus of students activities is mostly dedicated on verifying information previously transferred by the …

Microbial strategies to exploit host cells

2005

The European Research Conference (EURESCO) on Spatial and Temporal Dynamics of the Endomembrane System was held in sunny San Feliu de Guixols, Spain, between 16 and 21 October 2004. The conference was organized by D. Holden and H. Stenmark ![][1] By bringing together scientists from the fields of microbiology and cell biology, the European Research Conference (EURESCO) on ‘Spatial and Temporal Dynamics of the Endomembrane System’ combined the best of both worlds at the intersection where intracellular pathogens and host cells meet. The mixture of studies, which focused on the molecular mechanisms behind endocytic and secretory transport, and the pathogenic microbes that exploit these pathwa…

Management of Distal Radius Fractures in the Elderly Patients

2015

Distal radius fractures are one of the most common injuries treated by the orthopedic surgeons representing almost 1/6 of the fractures that are treated in the emergency departments and the 75% of all fractures of the upper limb and are second only to hip fractures in elderly population. The age distribution of this kind of injury is typically bimodal with peaks in the young patients (6-25) and in the elderly patients older than 65. In the first case the mechanism of injury is usually a high energy trauma, such as a car accident, whilst in the second one is usually a low energy trauma like a domestic fall. Various classification systems have been proposed for these fractures. The classic ep…

Ventricular arrhythmias in children: the uselessness of MRI.

2009

The p21-activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation

2013

The final size of the central nervous system is determined by precisely controlled generation, proliferation and death of neural stem cells. We show here that the Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central brain progenitor cells (neuroblasts) and becomes enriched to the apical cortex of neuroblasts in a cell cycle- and Cdc42-dependent manner. Using mushroom body neuroblasts as a model system, we demonstrate that in the absence of Mbt function, neuroblasts and their progeny are correctly specified and are able to generate different neuron subclasses as in the wild type, but are impaired in their proliferation activity throughout development. In general, loss of…

The serosa of Manduca sexta (Insecta, Lepidoptera): ontogeny, secretory activity, structural changes, and functional considerations

2001

In Manduca sexta, the blastoderm forms successively and becomes immediately cellularized as the cleavage energids reach the surface of the oocyte. Presumptive serosal cells are large and contain 2 or 4 large polyploid nuclei; presumptive embryonic cells are small and mononuclear. All parts of the blastoderm participate in the uptake and digestion of yolk material. About 10 h post-oviposition, the blastoderm breaks at the amnioserosal fold and the extraembryonic part closes above the germ band and constitutes the serosa (12 h post-oviposition, i.e. 10% development completed). At once, the serosa starts to secrete a cuticle consisting of an epi- and a lamellated endocuticle. Detachment of the…

Quantitative electron microscopic observations on Paneth cells of germfree and ex-germfree Wistar rats.

1986

Ultrastructural changes of Paneth cells of germfree (Gf) rats which had been inoculated with bacteria-containing feces from conventionally-reared (SPF) rats were quantitatively examined. 12 and 24 h after inoculation, the Paneth cells showed a striking decrease in the number of secretory granules and the occurrence of large vacuoles. Phagosomes containing bacteria were not seen. After 4 days, the secretory granules reaccumulated and smooth-surfaced apical vesicles increased in number. It is discussed that the large vacuoles may be related to membrane-retrieval events following the massive extrusion of secretory granules whereas the apical vesicles appear to serve this function when exocytos…

EMORRAGIE DIGESTIVE

2019

Digestive bleeding is considered to be blood loss originating from the gastrointestinal tract, in which bleeding occurs within the lumen of the digestive tract. They can occur in an acute or fit form chronic and should never be underestimated, in how they can lead to urgency / emergency and sometimes take the patient to the death. The incidence is equal to approximately 102 new cases / year per 100 000 people, with a rate of 20-25% of major bleeding and one 10% mortality.

Pulmonary hypertension in COPD and lung transplantation: Timing and procedures

2014

The prevalence of pulmonary hypertension (PH) in the general chronic obstructive pulmonary disease (COPD) population is undefined because stable COPD patients do not routinely undergo screening echocardiogram and right heart catheterization. Most studies published on this topic are focused on a highly selected group of patients with moderate to severe disease awaiting lung transplantation, since hemodynamic data from cardiac catheterization are part of the standard transplant evaluation. In a very recent article, Hurdman et al. studied the characteristics and outcomes, with a particular focus on mortality, of extensively phenotyped, consecutive patients with PH-COPD over a 9-year period. Th…

Dietary xenoestrogens differentially impair 3T3-L1 preadipocyte differentiation and persistently affect leptin synthesis

2008

International audience; Recent observations have highlighted adipogenesis alterations under exposure to several xenoestrogens at critical stages, and pointed at their possible involvement in the pathogenesis of obesity. However, it remains unclear whether these effects are mediated by classical estrogen receptor (ER) binding and subsequent transcriptional modulation. The aim of this study was to determine the (anti-)adipogenic impact of apigenin, bisphenol A, genistein and 17β-estradiol at the onset of adipose cell maturation, and to correlate it to their estrogenic potential. In steroid-free conditions, 3T3-L1 preadipocytes were induced to differentiate in the presence of xenoestrogens for…