Search results for "PPAR"

Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

2015

One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ1-42 depositions. Our results indicate that Aβ1-42 toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. Aβ1-42-induced deleterious neuronal effects are not present when neurons and astrocytes are mixed cultured. Stimulation of astrocytes with toxic Aβ1-42 peptide increased p-65 and decreased IκB resulting in inflammatory process. In astrocytes Aβ1-42 decreases protein expressions of sirtuin 1 (SIRT-1) and peroxisome proliferator-activated receptor γ (PPAR-γ) and over-expresses peroxisome proliferator-activated re…

Avoiding tunnel collisions between fibular collateral ligament and ACL posterolateral bundle reconstruction

2010

PURPOSE: The purpose of this study was to evaluate the risk of tunnel collisions of the fibular collateral ligament (FCL) and posterolateral bundle anterior cruciate ligament (PLB-ACL) tunnels during a combined FCL and double-dundle (DB) ACL reconstruction. METHODS: Thirty-six 4th-generation synthetic femurs (Sawbones, Pacific Research Laboratories, Vashon, WA) were utilized, and two different femur sizes were used. A FCL tunnel and a PLB-ACL tunnel were reamed on each femur. The tunnels of synthetic specimens that did not have a collision were filled with an epoxy resin augmented with BaSO(4) and radiographic evaluation, and Multidetector CT exams of the specimens were performed. RESULTS: …

How to avoid collision between PCL and MCL femoral tunnels during a simultaneous reconstruction.

2014

PURPOSE: The purpose of the present study was to assess the risk of femoral tunnel collisions between the medial collateral ligament (MCL) and the posterior cruciate ligament (PCL) tunnels during a simultaneous PCL and MCL reconstruction. METHODS: Fourth generation medium and large synthetic femur bones were used. On each femur, a MCL tunnel and a PCL tunnel were reamed. The MCL tunnel was drilled at 0°, 20° and 40° of axial and coronal angulations. The PCL femoral tunnel was reamed to simulate two different tunnel directions that could be obtained through an inside-out and outside-in technique. Tunnels were filled with epoxy resin augmented with BaSO4, and a multidetector CT examination of…

Membrane Integration of Poliovirus 2B Viroporin

2011

Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family. Prototypical viroporin 2B is responsible for the alterations in host cell membrane permeability that take place in enterovirus-infected cells. 2B protein can be localized at the endoplasmic reticulum (ER) and the Golgi complex, inducing membrane remodeling and the blockade of glycoprotein trafficking. These findings suggest that 2B has the potential to integrate into the ER membrane, but specific information regarding its biogenesis and mechanism of membrane insertion is lacking. Here, we report experimental results of in vi…

Apparent Molar Mass of a Polyelectrolyte in an Organic Solvent in the Low Ionic Strength Limit As Revealed by Light Scattering

2013

The apparent molar mass of a partially quaternized poly-2-vinylpyridines (degree of quaternization 4.3% < Q < 35%) in 1-propanol is measured by light scattering at low ionic strength (10–6 M < cs < 10–3 M) as a function of polyion repeat unit concentration (7 × 10–5 monomol/L < cm,p < 4 × 10–2 monomol/L). No dialysis was applied prior to measurements. The apparent molar mass under “salt-free” conditions is smaller than the true molar mass by an order of magnitude, while approaching the true value at higher ionic strength. Concomitant data on the dependence of scattering intensity on scattering wave vector show that the dilute polyelectrolyte solutions are strongly correlated. A recent theor…

Apparent molar volumes of strontium chloride in ethanol + water at 298.15 K

1997

Densities of ethanol + water + strontium chloride mixtures have been measured with an oscillating-tube densimeter over a large range of concentrations of the salt and ethanol, at 298.15 K. From these densities, apparent molar volumes of the electrolyte in these mixtures have been calculated, and partial molar volumes at infinite dilution have been evaluated.

Theory and Simulations of Friction between Flat Surfaces Lubricated by Submonolayers

2001

Recent simulations suggest that wearless friction between two solid surfaces can only be obtained if the two surfaces are commensurate or if they are lubricated by a film. Some simple theoretical arguments are given why the presence of a submonolayer film between two solids leads to friction. Possible implications of the symmetry of the confining walls on the tribological properties of the system are then investigated in the presence of a thin film by means of molecular dynamics simulation. Erratic stick-slip motion of the incommensurate system and oscillating friction forces for the commensurate system in the sliding regime are observed.

Zurich et le Monte Verità, un binôme favorable aux échanges entre Dada et la danse

2021

National audience

Motilità dell’apparato digerente

2009

Post-bronchoscopy fatal endobronchial hemorrhage in a woman with bronchopulmonary mucormycosis: a case report

2010

Abstract Introduction During infection, Mucorales fungi invade major blood vessels, leading to extensive necrosis, and in cases of extensive pulmonary disease, bleeding into the lungs may occur. Case presentation We report an unexpected event of post-bronchoscopy fatal endobronchial hemorrhage in a 62-year-old HIV-negative Italian woman with well controlled diabetes mellitus who presented with diffuse cavitated pulmonary lesions. Fiberoptic bronchoscopy revealed bilateral obstruction of the segmental bronchi. Fatal massive bleeding occurred after standard biopsy procedures. Histologic examination showed that the hyphae were more deeply colored by hematoxylin-eosin (H&E) than by other stains…