Search results for "PPI"
showing 10 items of 7396 documents
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
2007
AbstractIntegrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines derived from patients with different B-NHLs delineated 20 homozygous deletions at 7 chromosome areas, all of which contained tumor suppressor gene targets. Further investigation revealed that only a fraction of primary biopsies presented inactivation of these genes by point mutation or intragenic deletion, but instead some of them w…
Protocol for Low-level laser therapy in traumatic ulcer after troncular anesthesia: Case report in pediatric dentistry
2020
The aim of this study was to report a protocol of use for low-level laser therapy (LLLT) in traumatic ulcer in the lower lip after inferior alveolar nerve block anesthesia (IANBA). A 3-year-old patient, male, undergoing treatment of carious lesions was submitted to an indirect pulp capping in tooth 74 under IANBA. The procedure was completed without intercurrences, but on next day, the child presented extensive traumatic ulcer in the left lower lip, with complaint of pain. Two sequential applications with LLLT were applied in punctual mode under pressure around the lesion. After 1 week, the mother reported significant improvement. After 30 days, the lesion was fully healed. In conclusion, L…
The origins of the European city. Technology, typology and function of wooden architecture in the urban habitat of Celtic oppida (2nd-1st century BC)…
2020
The aim of this thesis is to shed light on current knowledge of the architecture of the oppida of temperate Europe during the last two centuries BC, based on a site, the Bibracte oppidum (Mont Beuvray, Burgundy), which is one of the reference contexts for the period on a European scale. The research focused mainly on the study of construction techniques involving the majority use of wood, which is the main material in the architecture of these settlements from the European protohistoric tradition. The analysis required consideration of the overall woodworking process, from the sourcing of wood from the forest to the various stages of building implementation. The technical aspects linked to …
Well-being and tourist experiences : a state of the art review of positive psychology studies
2017
Currently, well-being concerns individuals but also businesses and even countries. This article thus provides a synthesis of psychological researches on well-being and of those bringing closer well-being and tourism, this activity maintaining obvious links with well-being. The aim is to better understand their relationships and to offer, in particular to tourist operators, marketing recommendations suggested by the reviewed studies.
L'alimentation sur l'oppidum de Boviolles (Meuse) : regards croisés sur la faune, les graines la vaisselle et l'instrumentum
2014
In dem Artikel werden verschiedene Gattungen archäologischer Funde aus dem oppidum von Boviolles (Meuse, Lorraine) vorgestellt, die in Zusammenhang mit der Ernährung stehen. In der Zusammenschau geben sie Auskunft zu den Ernährungsgewohnheiten im spätlaténezeitlichen oppidum von Boviolles (Meuse, Lorraine), das während des ersten Jahrhunderts vor Ch. der Hauptort der Leuker war
Impaired cognitive control in patients with brain tumors
2021
Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investigated. The objective of this study was to examine proactive and reactive control functions in patients with focal brain tumors and to identify lesioned brain areas more at "risk" for developing impairment of these functions. To this end, a group of twenty-two patients, candidate to surgery, were tested with an AX-CPT task and a Stroop task, along with a clinical neuropsychological assessment, and their performance was compared to that of a well-matched healthy control group. Although overall ac…
Functional connectivity inference from fMRI data using multivariate information measures
2022
Abstract Shannon’s entropy or an extension of Shannon’s entropy can be used to quantify information transmission between or among variables. Mutual information is the pair-wise information that captures nonlinear relationships between variables. It is more robust than linear correlation methods. Beyond mutual information, two generalizations are defined for multivariate distributions: interaction information or co-information and total correlation or multi-mutual information. In comparison to mutual information, interaction information and total correlation are underutilized and poorly studied in applied neuroscience research. Quantifying information flow between brain regions is not explic…
On the Neurocognitive Co‐Evolution of Tool Behavior and Language: Insights from the Massive Redeployment Framework
2021
Understanding the link between brain evolution and the evolution of distinctive features of modern human cognition is a fundamental challenge. A still unresolved question concerns the co-evolution of tool behavior (i.e., tool use or tool making) and language. The shared neurocognitive processes hypothesis suggests that the emergence of the combinatorial component of language skills within the frontal lobe/Broca's area made possible the complexification of tool-making skills. The importance of the frontal lobe/Broca's area in tool behavior is somewhat surprising with regard to the literature on neuropsychology and cognitive neuroscience, which has instead stressed the critical role of the le…
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson’s Disease
2021
Background: Movement execution is impaired in patients with Parkinson’s disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson’s disease patients remains largely unexplored. Objective: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. Methods: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recor…
Bipolar disorder: A neural network perspective on a disorder of emotion and motivation
2013
Bipolar disorder (BD) is a severe, chronic disease with a heritability of 60-80%. BD is frequently misdiagnosed due to phenomenological overlap with other psychopathologies, an important issue that calls for the identification of biological and psychological vulnerability and disease markers. Altered structural and functional connectivity, mainly between limbic and prefrontal brain areas, have been proposed to underlie emotional and motivational dysregulation in BD and might represent relevant vulnerability and disease markers. In the present laboratory review we discuss functional and structural neuroimaging findings on emotional and motivational dysregulation from our research group in BD…