Search results for "PPO"
showing 10 items of 5642 documents
A Novel Border Identification Algorithm Based on an “Anti-Bayesian” Paradigm
2013
Published version of a chapter in the book: Computer Analysis of Images and Patterns. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-40261-6_23 Border Identification (BI) algorithms, a subset of Prototype Reduction Schemes (PRS) aim to reduce the number of training vectors so that the reduced set (the border set) contains only those patterns which lie near the border of the classes, and have sufficient information to perform a meaningful classification. However, one can see that the true border patterns (“near” border) are not able to perform the task independently as they are not able to always distinguish the testing samples. Thus, researchers have worked on thi…
The Challenge of Coexistence in Socially Vulnerable Schools
2017
Abstract Society in general and schools in particular continue to express their concerns with regard to the many challenges posed nowadays by living in a globalized world, where learning to coexist involves knowing oneself and those around us. Therefore, the professionals from the education sector and specially from the most vulnerable contexts demand the necessity to know strategies and initiatives which enable them to build a democratic school, where learning to coexist is the key to educate engaged citizens living in an increasingly intercultural, changing world. The study presented here has been conducted in two differentiated, but complementary, phases. During the first phase a documen…
Cognitive biases in humanitarian sensemaking and decision-making lessons from field research
2016
Time and again, humanitarian decision-makers are confronted with stress and pressure, distorted, lacking and uncertain information, and thus they are working in conditions that are known to introduce or enforce biases. Decision analysis has been designed to overcome such biases, and a network of “digital responders” organized over the Internet has set out to improve judgments by providing better information. However, without any structured support to determine objectives, goals and preferences and detached from the context of operational decision-makers, remote analysts may face the very biases they are trying to help overcome. This article sets out to identify biases that matter for humani…
Towards a Bangsamoro in Mindanao?
2017
Mindanao was already settled by Muslims when the Spanish colonization began. Today, the western part of the island and the Sulu archipelago are territories with a majority Muslim population, whereas the rest of the Philippines is predominantly Christian. Since the sixteenth century, the “Moros” of Mindanao have fought outsiders, Spaniards first, then the Americans, and throughout history the other Filipinos. The settlement migration policy of the Philippine government in the middle of the twentieth century has transformed the human landscape of the central and eastern parts of Mindanao, now predominantly Christian, and created a major area of commercial plantations. Political opposition to …
Influence of Biologically Oriented Preparation Technique on Peri-Implant Tissues; Prospective Randomized Clinical Trial with Three-Year Follow-Up. Pa…
2019
Purpose: The objective of this prospective randomized clinical trial (RCT) was to analyze and compare the clinical behavior of three types of prosthesis supported by single implants in the posterior region after three years functional loading. Materials and Methods: Seventy-five implants were divided into three groups according to the type of prosthetic restoration: screw-retained crown (Group GS); cemented crown without finishing line (biologically oriented preparation technique) (Group GBOPT); and conventional cemented crown with finishing line (Group GCC). The clinical behavior of each restoration type was analyzed after 3 years functional loading by analyzing radiographic peri-implant b…
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
2020
Adult hippocampal neurogenesis was originally discovered in rodents. Subsequent studies identified the adult neural stem cells and found important links between adult neurogenesis and plasticity, behavior, and disease. However, whether new neurons are produced in the human dentate gyrus (DG) during healthy aging is still debated. We and others readily observe proliferating neural progenitors in the infant hippocampus near immature cells expressing doublecortin (DCX), but the number of such cells decreases in children and few, if any, are present in adults. Recent investigations using dual antigen retrieval find many cells stained by DCX antibodies in adult human DG. This has been interprete…
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
2018
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus(1-5). This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease(6-10). In humans, some studies have suggested that hundreds of new neurons are added to the adult dentate gyrus every day(11), whereas other studies find many fewer putative new neurons(12-14). Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal …
Adjuvant chemotherapy and relative survival of patients with stage II colon cancer - A EURECCA international comparison between the Netherlands, Denm…
2016
BACKGROUND: The aim of the present EURECCA international comparison is to compare adjuvant chemotherapy and relative survival of patients with stage II colon cancer between European countries.METHODS: Population-based national cohort data (2004-2009) from the Netherlands (NL), Denmark (DK), Sweden (SE), England (ENG), Ireland (IE), and Belgium (BE) were obtained, as well as single-centre data from Lithuania. All surgically treated patients with stage II colon cancer were included. The proportion of patients receiving adjuvant chemotherapy was calculated and compared between countries. Besides, relative survival was calculated and compared between countries.RESULTS: Overall, 59,154 patients …
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
2020
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse model of DS and DS individuals, we found activated microglia, as assessed by their morphology; activation markers; and, for DS mice, electrophysiological profile. Accordingly, we found increased pro-inflammatory cytokine levels and altered interferon signaling in Dp(16) hippocampi. DS mice also showed decreased spine density and activity of hippocampal neurons and hippocampus-depe…