Search results for "PPP"

The broad phenotypic spectrum of PPP2R1A -related neurodevelopmental disorders correlates with the degree of biochemical dysfunction

2021

PURPOSE: Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by characterizing 30 individuals with de novo and often recurrent variants in this PP2A scaffolding Aα subunit. METHODS: Most cases were identified through routine clinical diagnostics. Variants were biochemically characterized for phosphatase activity and interaction with other PP2A subunits. RESULTS: We describe 30 individuals with 16 different variants in PPP2R1A, 21 of whom had variants not previously reported. The severity of developmental delay …

The Role of Firms and Institutional Actors in Developing the Catania Nanotech Network

2009

Obiettivo del lavoro e` quello di esaminare nell`ambito dell sviluppo regionale l`importanza della rete di imprese quale attore istituzionale inserito all`interno delle strutture socioeconomiche locali. In tale ambito si osserva come l`interazione pubblico-privato e` essenziale per supportare le istituzioni locali in aree economiche in ritardo come la Sicilia

Modelos de gestión en áreas comerciales urbanas: centros comerciales abiertos en España

2014

Los partenariados públicos-privados (PPP) en áreas comerciales urbanas son proyectos de cooperación entre la administración pública y los comerciantes locales que persiguen un mismo objetivo: la recuperación funcional y económica de una determinada área urbana. Desde su nacimiento en Norteamérica, los PPP han ido adaptándose a la estructura empresarial, cultural y política de su entorno regional. España, que adoptó este tipo de proyectos de PPP más recientemente, se encuentra en la actualidad en un momento decisivo para replantear la fórmula de gestión y financiación de sus proyectos ya consolidados.

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

2008

Cancer continues to be one of the major health and socio-economic problems worldwide, despite considerable efforts to improve its early diagnosis and treatment. The identification of new constituents as biomarkers for early diagnosis of neoplastic cells and the discovery of new type of drugs with their mechanistic actions are crucial to improve cancer therapy. New drugs have entered the market, thanks to industrial and legislative efforts ensuring continuity of pharmaceutical development. New targets have been identified, but cancer therapy and the anti-cancer drug market still partly depend on anti-mitotic agents. The objective of this paper is to show the effects of KAR-2, a potent anti-m…

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

2006

Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis and glucose degradation to lactate. The nonoxidative part of the PPP is controlled by transketolase enzyme reactions. We have detected upregulation of a mutated transketolase transcript (TKTL1) in human malignancies, whereas transketolase (TKT) and transketolase-like-2 (TKTL2) transcripts were not upregulated. Strong TKTL1 protein expression was correlated to invasive colon and urothelial tumours and to poor patients outcome. TKTL1 encodes a transketolase with unusual enzymatic prop…

NRTK, PPP or Static, That Is the Question. Testing Different Positioning Solutions for GNSS Survey

2021

Worldwide, the determination of the coordinates from a Global Navigation Satellite System (GNSS) survey (in Network Real Time Kinematic, Precise Point Positioning, or static mode) has been analysed in several scientific and technical applications. Many of those have been carried out to compare Precise Point Positioning (PPP), Network Real Time Kinematic (NRTK), and static modes’ solutions, usually, using the latter as the true or the most plausible solution. This approach is not always possible as the static mode solution depends on several parameters (baseline length, acquisition time, ionospheric, and tropospheric models, etc.) that must be considered to evaluate the accuracy of the metho…

Public-Private Partnership: Transaction Costs of Tendering

2016

Abstract What are the transaction costs of participating in a public-private partnership (PPP) tender? Prior research indicate that there is a significant amount of resources required. However, few researchers seem to measure transaction costs directly. The purpose of this paper is therefore to fill this knowledge gap by presenting estimated transaction costs from both public and private actors. The underlying approach for this research was a case study of a new primary school in Norway. This case was chosen because of the expedient access to detailed information of the tendering process. The main source of data was documents and estimated figures obtained from public and private actors inv…

Financial Sustainability and Morphogenesis of Urban Transformation Project

2015

The urban transformation projects are very complex and have to be examined from several points of view (socio-cultural, environmental, infrastructural, administrative, and economic-financial) to determine their sustainability. This study aims to test the financial analysis as a tool for outlining the morphogenesis of the project’s characteristics and exploring the frontiers of the financial feasibility especially when the urban projects, according to Italian laws, involve Public Private Partnerships (PPPs). A financial model is applied to a case study (the transformation of an abandoned railway area) in which the absence of an adequate returns on investment, because of the crisis of the rea…

L’espressione del “peroxisome proliferator-activated gamma” (PPARgamma) nelle tireopatie croniche autoimmuni

2003

Performance assessment of PPP surveys with open source software using the GNSS GPS-GLONASS-Galileo constellations

2020

In this work, the performance of the multi-GNSS (Global Navigation Satellite System) Precise Point Positioning (PPP) technique, in static mode, is analyzed. Specifically, GPS (Global Positioning System), GLONASS, and Galileo systems are considered, and quantifying the Galileo contribution is one of the main objectives. The open source software RTKLib is adopted to process the data, with precise satellite orbits and clocks from CNES (Centre National d&rsquo