Search results for "PRC"
showing 6 items of 16 documents
Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation
2010
SummaryPolycomb group (PcG) proteins are conserved epigenetic transcriptional repressors that control numerous developmental gene expression programs and have recently been implicated in modulating embryonic stem cell (ESC) fate. We identified the PcG protein PCL2 (polycomb-like 2) in a genome-wide screen for regulators of self-renewal and pluripotency and predicted that it would play an important role in mouse ESC-fate determination. Using multiple biochemical strategies, we provide evidence that PCL2 is a Polycomb Repressive Complex 2 (PRC2)-associated protein in mouse ESCs. Knockdown of Pcl2 in ESCs resulted in heightened self-renewal characteristics, defects in differentiation, and alte…
Osservatorio della Corte costituzionale (n. 3/2019)
2019
Corte cost. n. 250 del 2018 (in tema di regime dell’aggravamento della misura di sicurezza, rigidi automatismi e letture costituzionalmente orientate)
Modeling and simulation of a High Pressure Roller Crusher for silicon carbide production
2011
Author's version of a chapter published in the book: 11th International Conference on Electrical Power Quality and Utilisation. Also available from the publisher at: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6128963&tag=1 This paper describes the modeling and simulation of High Pressure Roller Crusher (HPRC) for the production of silicon cabide grains. The study is to make a model for simulation of a High Pressure Roller Crusher. A High Pressure Roller Crusher (HPRC) is an important part in the production of silicon carbide, where the grains are crushed into powder form and then sieved into specified sizes based on its usage. This paper will present a model based on Johanson's…
Characterization of the ligands for the human umami taste receptor
2017
National audience; Among our basics senses, taste and our gustatory system allow us to perceive and recognize essential chemical nutrients present in food. Human can detect and discriminate five basics taste (sweet, bitter, sour, salty and umami) and recent studies proposed a sixth taste for fat. The umami taste is described as a « savory » sensation elicited mainly by L-amino acids and is thought to serve as an indicator of protein rich foods and promote feeding.The umami taste receptor is a heterodimeric receptor composed of the T1R1 and T1R3 subunits. These subunits belong to the family class C G protein-coupled receptors (GPCRs) and are constituted by a large N-terminal domain (NTD) lin…
A Derrota da Esquerda como a Direita Gosta
2001
Itália. Abril de 1996. Facto histórico. O antigo maior partido comunista do Ocidente, aliado à pequenas agregações centristas, vence as eleições nacionais, depois de passar 50 anos à margem da gestão do Estado, devido ao veto ianque, da Igreja e do capital, apesar de contar com cerca de 30% do eleitorado. O Partido da Refundação Comunista, que nascera em 1991, quando o PCI mudara de nome para Partido dos Democratas de Esquerda [PDS], assumindo-se social-democrata, apoiara, de fora, a coligação. O PRC formara-se com operários, Estalinistas, maoistas, sindicalistas, trotskistas, etc. que se haviam negado a terminar a luta anti-capitalista. Nem mesmo no horizonte político, a coligação do Ulivo…
Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell
2015
AbstractTaste receptors on enteroendocrine cells sense nutrients and transmit signals that control gut hormone release. This study aimed to investigate the amino acid (AA) sensing mechanisms of the ghrelin cell in a gastric ghrelinoma cell line, tissue segments and mice. Peptone and specific classes of amino acids stimulate ghrelin secretion in the ghrelinoma cell line. Sensing of L-Phe occurs via the CaSR, monosodium glutamate via the TAS1R1-TAS1R3 while L-Ala and peptone act via 2 different amino acid taste receptors: CaSR & TAS1R1-TAS1R3 and CaSR & GPRC6A, respectively. The stimulatory effect of peptone on ghrelin release was mimicked ex vivo in gastric but not in jejunal tissue …