Search results for "PRENATAL EXPOSURE"

showing 10 items of 161 documents

Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort

2017

BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort. METHODS: We measured PFHxS, PFOS, PFOA, and PFNA in 1st-trimester maternal plasma (years: 2003-2008) in 1202 mother-child pairs. Continuous birth outcomes included standardized weight, length, he…

MaleEmbaràsFetal growth010501 environmental sciences01 natural sciencesToxicologychemistry.chemical_compound0302 clinical medicinePregnancyContaminantsBirth Weight030212 general & internal medicinelcsh:Environmental sciencesGeneral Environmental Sciencelcsh:GE1-350FluorocarbonsFluorocarbursObstetricsPregnancy OutcomeGestational ageHispanic or Latino3. Good healthAlkanesulfonic AcidsPerfluorooctanoate (PFOA)Àcids alcanoicsPrenatal Exposure Delayed EffectsEnvironmental PollutantsFemalePerfluorooctane sulfonate (PFOS)Glomerular filtration ratemedicine.symptomCaprylatesBirth cohortAdultmedicine.medical_specialtyBirth weightRenal functionGestational AgeINMA birth cohort03 medical and health sciencesmedicineHumans0105 earth and related environmental sciencesPregnancyInfant Newbornmedicine.diseasePerfluorooctaneLow birth weightPerfluoroalkyl substanceschemistryMother-child pairsParity (mathematics)
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Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies

2020

Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 mother-child pairs. Methods: Concentrations of PFOS and PFOA were measured in maternal serum/plasma during pregnancy, or in breast milk, with different timing of sample collection in each cohort. We used a validated pharmacokinetic model of pregnancy and lactation to estimate…

MaleHealth Toxicology and MutagenesisReproductive health and childbirth010501 environmental sciencesToxicology01 natural sciencesMedical and Health SciencesCohort Studies0302 clinical medicinePregnancyMedicine2.2 Factors relating to the physical environment030212 general & internal medicineAetiologyChildPediatricFluorocarbonsEarly life3. Good healthPeer reviewMilkBreast FeedingMental HealthAlkanesulfonic AcidsMeta-analysisChild PreschoolPrenatal Exposure Delayed EffectsEnvironmental PollutantsFemaleCaprylatesHumanPopulationMEDLINEMothers03 medical and health sciencesEnvironmental healthmental disordersHumansPreschool0105 earth and related environmental sciencesMilk Humanbusiness.industryResearchPublic Health Environmental and Occupational HealthEuropean populationEnvironmental Exposurebiochemical phenomena metabolism and nutritionAttention Deficit Hyperactivity Disorder (ADHD)Attention Deficit Disorder with HyperactivityAttention deficitbusinessEnvironmental SciencesEnvironmental Health Perspectives
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Systematic review of prenatal exposure to endocrine disrupting chemicals and autism spectrum disorder in offspring.

2021

Epidemiological studies, which can have inherent methodological limitations, are used to study the relation between endocrine disrupting chemicals and autism spectrum disorder. The objective is to systematically review the treatment of methodological limitations and assess the quality and strength of the findings in the available literature. The quality and strength of the evidence were evaluated using the Navigation Guide Systematic Review Methodology. The overall quality and strength of the available studies were “moderate” and “limited,” respectively. Risk of bias due to the methodological limitations regarding the exclusion of potential confounding factors and the lack of accuracy of e…

OffspringAutism Spectrum DisorderEndocrine Disruptorsmedicine.diseaseAutism spectrum disorderPregnancyRisk FactorsPrenatal Exposure Delayed EffectsDevelopmental and Educational PsychologymedicineEndocrine systemAutismHumansFemaleStereotyped BehaviorPsychologyPrenatal exposureClinical psychologyAutism : the international journal of research and practice
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Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

2021

This study was funded by Grants from EU (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1); Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142 and PI19/1338; Miguel Servet FEDER MS15/00025, MS20/0006, CPII16/00051, and FIS-FSE: 17/00260); CIBERESP; Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), AICO/2020/285, and Alicia Koplowitz Foundation 2017; Generalitat de Catalunya-CIRIT 1999SGR 00241; Department of Health…

metalloidsEnvironmental EngineeringPlacentaHealth Toxicology and Mutagenesisenvironmental exposuremetalsprenatal exposure010501 environmental sciences01 natural sciences03 medical and health sciences0302 clinical medicinePregnancyMetals HeavyPolitical sciencePrenatal exposureHumansEnvironmental ChemistryLongitudinal StudiesProspective Studies030212 general & internal medicineSocioeconomicsPrenatal exposure0105 earth and related environmental sciencesMetalloidsInfant NewbornPublic Health Environmental and Occupational HealthGeneral MedicineGeneral ChemistryEnvironmental exposureEnvironmental exposurePollution3. Good healthDietSpain13. Climate actionMetalsFemaleChristian ministryPregnant WomendietEnvironmental Monitoring
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The association between passive and active tobacco smoke exposure and child weight status among Spanish children

2016

This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041), Spanish Ministry of Health (FIS-97/1102, FIS07/0252,FIS-PS09/00362, 97/0588, 00/0021-2, PI061756, PS0901958, PI14/00677 incl. FEDER funds, FIS-PS09/00090, PI041436, FIS-PI042018, FIS-PI06/0867,PI081151 incl. FEDER funds, FIS-PI09/02311, and FIS-PI13/02187 and FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/0178, 11/02591, 11/02038, PI12/01890 incl. FEDER funds, 13/1944, 13/2032, FIS-PI13/02429, 14/0891, 14/1687, and CP13/00054 incl. FEDER funds), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), CIBERES…

Nutrition and Dieteticsbusiness.industryEndocrinology Diabetes and MetabolismTobacco smoke exposureMedicine (miscellaneous)010501 environmental sciencesBody weight01 natural sciences03 medical and health sciences0302 clinical medicineEndocrinologyPrenatal Exposure Delayed EffectsEnvironmental healthMedicineChristian ministry030212 general & internal medicineHealth behaviorbusinessWeight statusHumanities0105 earth and related environmental sciencesObesity
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Integrated and diurnal indices of maternal pregnancy cortisol in relation to sex-specific parasympathetic responsivity to stress in infants.

2020

Maternal hypothalamic-pituitary-adrenal (HPA) axis activity may prenatally program sex-specific stress response pathways. We investigated associations between maternal cortisol during pregnancy and infant parasympathetic responsivity to stress among 204 mother-infant pairs. Cortisol indices included 3(rd) trimester hair cortisol, as well as diurnal slope and area under the curve, derived from saliva samples collected during pregnancy. Mother-infant dyads participated in the Repeated Still-Face Paradigm (SFP-R) at age 6 months. We calculated respiration-adjusted respiratory sinus arrhythmia (RSA(c)), an indicator of parasympathetic activation, from infant respiration and cardiac activity mea…

MaleSalivaendocrine systemHypothalamo-Hypophyseal SystemHydrocortisonePhysiologyMothersPituitary-Adrenal System3rd trimesterArticle03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineDevelopmental NeurosciencePregnancyRespirationDevelopmental and Educational PsychologymedicineHumans0501 psychology and cognitive sciencesVagal toneSalivaPregnancybusiness.industry05 social sciencesArea under the curveInfantmedicine.diseaseSex specificPrenatal Exposure Delayed EffectsAutonomic reactivityFemalebusiness030217 neurology & neurosurgeryhormones hormone substitutes and hormone antagonistsStress Psychological050104 developmental & child psychologyDevelopmental BiologyDevelopmental psychobiology
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Maternal cell phone use during pregnancy and child cognition at age 5 years in 3 birth cohorts

2018

Background: There have been few studies of children's cognitive development in relation to mothers' cell phone use, and most were limited to outcomes at age 3 years or younger. We examined the relationship between maternal cell phone use during pregnancy and cognitive performance in 5-year old children. Methods: This study included data from 3 birth cohorts: the Danish National Birth Cohort (DNBC) (n = 1209), Spanish Environment and Childhood Project (INMA) (n = 1383), and Korean Mothers and Children's Environment Health Study (MOCEH) (n = 497). All cohorts collected information about maternal cell phone use during pregnancy and cognitive performance in children at age 5. We performed linea…

Cell phonesIntelligenceMothersPooled analysisDanishCohort Studies03 medical and health sciences0302 clinical medicineChild DevelopmentCognitionPregnancyCognitive developmentMedicineHumans030212 general & internal medicineEffects of sleep deprivation on cognitive performanceChildChildrenlcsh:Environmental sciencesGeneral Environmental Sciencelcsh:GE1-350Pregnancybusiness.industryConfoundingCognitionmedicine.diseaselanguage.human_languageConfidence intervalCell Phone UseMeta-analysisPrenatal Exposure Delayed EffectsCohortlanguageFemalebusiness030217 neurology & neurosurgeryDemographyEnvironment International
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Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure

2014

It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development. This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development. In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 genotyping were included in the study,and the interactive influences of gender-GSTM1 genotyping-prenatal TSE on childhood asthma development were analyzed. Among these 591 children, 138 (23.4%) hadphysician-diagnosed asthmaat 6 years of age, and 347 (58.7%) werenull-GSTM1. Prenatal TSE significantly incre…

MalePediatricsmedicine.medical_specialtyArticle Subjectanimal diseasesTaiwanlcsh:MedicineComorbidityLower riskPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyPregnancyRisk FactorsGenotypePrevalencemedicineHumansGenetic Predisposition to DiseaseSex DistributionChildneoplasmsGenotypingGlutathione TransferaseAsthmaChildhood asthmaintegumentary systemGeneral Immunology and Microbiologybusiness.industrylcsh:RTobacco smoke exposureInfant NewbornInfantTotal igeGeneral Medicinemedicine.diseaseAsthmanervous system diseasesCausalityChild PreschoolPrenatal Exposure Delayed EffectsFemaleTobacco Smoke PollutionbusinessBirth cohortResearch ArticleBioMed Research International
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A Multiomics Study To Unravel the Effects of Developmental Exposure to Endosulfan in Rats: Molecular Explanation for Sex-Dependent Effects

2019

Exposure to low levels of environmental contaminants, including pesticides, induces neurodevelopmental toxicity. Environmental and food contaminants can reach the brain of the fetus, affecting brain development and leading to neurological dysfunction. The pesticide endosulfan is a persistent pollutant, and significant levels still remain detectable in the environment although its use is banned in some countries. In rats, endosulfan exposure during brain development alters motor activity, coordination, learning, and memory, even several months after uptake, and does so in a sex-dependent way. However, the molecular mechanisms driving these effects have not been studied in detail. In this wor…

MaleCerebellumInsecticidescerebellumPhysiologyCognitive NeuroscienceMetabolitePhysiologyBiologyMotor ActivityBiochemistry03 medical and health scienceschemistry.chemical_compoundPhosphatidylinositol 3-Kinases0302 clinical medicineImmune systemSex FactorsPregnancyneurotoxicitymedicineCyclic GMP-Dependent Protein KinasesAnimalsCyclic GMPdevelopmentEndosulfanpesticide030304 developmental biologyCalcium signaling0303 health sciencesFetusBehavior AnimalNeurotoxicityCell BiologyGeneral Medicinemedicine.diseasesignaling pathwaysRatsmedicine.anatomical_structurechemistryPrenatal Exposure Delayed EffectsToxicityFemaleTranscriptome030217 neurology & neurosurgeryEndosulfanmultiomicsSignal Transduction
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Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, d…

2006

Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnatal day 2 until 21, on: unconditioned fear/anxiety-like behaviour in open field and in elevated plus-maze; learning performance in the "Can test", a non-aversive spatial and tactile/visual task; corticosterone plasma levels under basal and stress-induced conditions. Our results indicate that both prenatal stress and maternal separation procedures decrease emotionality and enhance…

Malemedicine.medical_specialtySettore BIO/14 - FARMACOLOGIAOffspringPrenatal stress Maternal separation Adolescent ra tBehaviour CorticosteroneAnxietyStatistics NonparametricOpen fieldDiscrimination LearningRandom AllocationBehavioral Neurosciencechemistry.chemical_compoundPregnancyEmotionalityCorticosteroneInternal medicineAdaptation PsychologicalmedicineAnimalslearning performanceRats WistarAnalysis of VarianceMaternal deprivationPregnancyMaternal DeprivationAge Factorsmedicine.diseaseRatsbehaviourEndocrinologyPrenatal stresschemistryprenatal stressPrenatal Exposure Delayed EffectsExploratory BehaviorFemaleAnalysis of varianceCorticosteronePsychologyStress Psychological
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