Search results for "PROB"
showing 10 items of 8859 documents
Supramolecular Association of Halochromic Switches and Halloysite Nanotubes in Fluorescent Nanoprobes for Tumor Detection
2022
Fluorescence imaging has become an indispensable tool in the biomedical laboratory to elucidate the fundamental dynamic and structural factors regulating cellular processes. The development of fluorescent nanoprobes represents a challenge to detect any cellular process under a microscope. Herein, a fluorescent nanomaterial was synthesized by exploiting the supramolecular interaction between a halochromic switch (1Cl) and halloysite nanotubes (HNTs). The successful synthesis of a HNTs/1Cl nanomaterial was confirmed by thermogravimetric analysis and Fourier transform infrared. The aqueous mobility was investigated by dynamic light scattering and ζ-potential measurements as well. Furthermore, …
Bio-orthogonal Red and Far-Red Fluorogenic Probes for Wash-Free Live-Cell and Super-resolution Microscopy
2021
Small-molecule fluorophores enable the observation of biomolecules in their native context with fluorescence microscopy. Specific labeling via bio-orthogonal tetrazine chemistry combines minimal label size with rapid labeling kinetics. At the same time, fluorogenic tetrazine–dye conjugates exhibit efficient quenching of dyes prior to target binding. However, live-cell compatible long-wavelength fluorophores with strong fluorogenicity have been difficult to realize. Here, we report close proximity tetrazine–dye conjugates with minimal distance between tetrazine and the fluorophore. Two synthetic routes give access to a series of cell-permeable and -impermeable dyes including highly fluorogen…
Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites
2017
Drug resistant focal epilepsy can be treated by resecting the epileptic focus requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes. As commercial SEEG probes offer only a limited spatial resolution, probes of higher channel count and design freedom enabling the incorporation of macro and microelectrodes would help increasing spatial resolution and thus open new perspectives for investigating mechanisms underlying focal epilepsy and its treatment. This work describes a new fabrication process for SEEG probes with materials and dimensions similar to clinical probes enabling recording single neuron activity at high spatial resolution.Polyimide is used as a bi…
Search strategies in innovation networks: The case of the Hungarian food industry
2020
In the food sector, open innovation has become of particular interest. This paper considers open innovation search strategies in the food and beverages industry and examines the probability of using different innovation sources with respect to the type of innovation. Although the information search for new ideas, tools and solutions in the innovation process regarding the scope and depth is well explored and interpreted in the literature, the probability of using the different sources with respect to type of innovation is rarely investigated. To answer these questions, first a probit, then OLS regression model is adopted, in order to understand the chance of a specific source of information…
La gestión en educación física. Dos modelos de gestión, el mismo individuo
2020
In the development of this writing, we intend to critically analyze the idea of management in Physical Education and problematize it with the issues of inclusion and inequality. To do this, first there is a brief etymological review of the concept of management, and then we analyze how Physical Education links management to economic and business Sciences. The analysis material used are books, manuals and articles on Physical Education management. From the analysis of this material, the second point of the work arises to explain two management models in Physical Education that we call: individual management and self-management. These models are presented as different and opposite, but in the…
What is Mathematics: Gödel's Theorem and Around (Edition 2015)
2015
Hyper-textbook for students in mathematical logic and foundations of mathematics. Edition 2015.
An optimization-based approach for solving a time-harmonic multiphysical wave problem with higher-order schemes
2013
This study considers developing numerical solution techniques for the computer simulations of time-harmonic fluid-structure interaction between acoustic and elastic waves. The focus is on the efficiency of an iterative solution method based on a controllability approach and spectral elements. We concentrate on the model, in which the acoustic waves in the fluid domain are modeled by using the velocity potential and the elastic waves in the structure domain are modeled by using displacement.Traditionally, the complex-valued time-harmonic equations are used for solving the time-harmonic problems. Instead of that, we focus on finding periodic solutions without solving the time-harmonic problem…
On the discreet spectrum of fractional quantum hydrogen atom in two dimensions
2019
We consider a fractional generalization of two-dimensional (2D) quantum-mechanical Kepler problem corresponding to 2D hydrogen atom. Our main finding is that the solution for discreet spectrum exists only for $\mu>1$ (more specifically $1 < \mu \leq 2$, where $\mu=2$ corresponds to "ordinary" 2D hydrogenic problem), where $\mu$ is the L\'evy index. We show also that in fractional 2D hydrogen atom, the orbital momentum degeneracy is lifted so that its energy starts to depend not only on principal quantum number $n$ but also on orbital $m$. To solve the spectral problem, we pass to the momentum representation, where we apply the variational method. This permits to obtain approximate analytica…
Inverse problems for a fractional conductivity equation
2020
This paper shows global uniqueness in two inverse problems for a fractional conductivity equation: an unknown conductivity in a bounded domain is uniquely determined by measurements of solutions taken in arbitrary open, possibly disjoint subsets of the exterior. Both the cases of infinitely many measurements and a single measurement are addressed. The results are based on a reduction from the fractional conductivity equation to the fractional Schr\"odinger equation, and as such represent extensions of previous works. Moreover, a simple application is shown in which the fractional conductivity equation is put into relation with a long jump random walk with weights.
Ongelmaeläimyyden monet ja muuttuvat määrittelyt
2022
Suomeen 1900-luvun puolivälin paikkeilla levinnyt supikoira (Nyctereutes procyonoides) on herättänyt monenlaista huolta ja keskustelua yhteiskunnan eri tasoilla ja ryhmittymissä. Supikoirakannan vähentämiselle löytyy vähän vastustajia, mutta osalle tämä keskikokoinen nisäkäs näyttää olevan niin iso ongelma, että supikoirapuhe saa paikoin raivokkaita sävyjä. Tarkastelen tässä tutkimuksessa keskustelun ongelmaeläinkäsityksiä kehysanalyysillä. Käytän uusstrukturalistiseen kehikkoon sijoittuvassa tarkastelussa sanomalehtien supikoirakirjoituksia aikaväliltä 1970–2020, jolle sijoittuu myös rakennemuutosten ja ympäristöheräämisen kaltaisia suomalaista yhteiskuntaa ja sen ympäristösuhdetta uudelle…