Search results for "PROFILE"
showing 10 items of 915 documents
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Identification of Bioactive Compounds in Polar and Nonpolar Extracts of Araujia sericifera
2017
Abstract Araujia sericifera is a native perennial, climbing laticiferous shrub from South America that is currently naturalized in many other countries. Previous data describe promising properties for A. sericifera, but no systematic study of its bioactive compounds and possible medicinal applications has been conducted to date. In the present study, aerial parts of A. sericifera (leaves, stems, and fruits) were explored by combining GC-MS and NMR spectroscopy analysis for both nonpolar (hexane) and polar (methanol) extracts. The hexanic extracts contained high amounts of pentacyclic triterpenes including two new metabolites, 3-tigloyl germanicol (18) and 3-tigloyl lupeol (19). The methanol…
Economic Feasibility of Measures for Energy Efficiency
2014
In this chapter the economic impact of some measures for energy efficiency, both using automation of technical infrastructures (according to EN 15232) as well as implementing passive measures concerning the use of building materials and techniques (according to EN 15271), is studied. The chapter is organized as follows. First, a technical-economical study on the evaluation of the impact on residential buildings of Building Automation Control, BAC, and Technical Building Management, TBM, systems is presented. Then the same assessment of some passive measures that can be employed is carried out using the Passive House Standard for Mediterranean warm climates is shown. Numerical elaborations h…
Statistical modeling, simulation, and experimental verification of wideband indoor mobile radio channel
2018
This paper focuses on the modeling, simulation, and experimental verification of wideband single-input single-output (SISO) mobile fading channels for indoor propagation environments. The indoor reference channel model is derived from a geometrical rectangle scattering model, which consists of an infinite number of scatterers. It is assumed that the scatterers are exponentially distributed over the two-dimensional (2D) horizontal plane of a rectangular room. Analytical expressions are derived for the probability density function (PDF) of the angle of arrival (AOA), the PDF of the propagation path length, the power delay profile (PDP), and the frequency correlation function (FCF). An efficie…
The accretion flow to the intermittent accreting ms pulsar, HETE J1900.1-2455, as observed by XMM-Newton and RXTE
2012
We present a study of the accretion flow to the intermittent accreting millisecond pulsar, HETE J1900.1-2455, based on observations performed simultaneously by XMM-Newton and RXTE. The 0.33-50 keV spectrum is described by the sum of a hard Comptonized component originated in an optically thin {\tau}~1 corona, a soft kTin~0.2 keV component interpreted as accretion disc emission, and of disc reflection of the hard component. Two emission features are detected at energies of 0.98(1) and 6.58(7) keV, respectively. The latter is identified as K{\alpha} transition of Fe XXIII-XXV. A simultaneous detection in EPIC-pn, EPIC-MOS2, and RGS spectra favours an astrophysical origin also for the former, …
Active faulting and continental slope instability in the Gulf of Patti (Tyrrhenian side of NE Sicily, Italy): a field, marine and seismological joint…
2016
The Gulf of Patti and its onshore sector represent one of the most seismically active regions of the Italian Peninsula. Over the period 1984–2014, about 1800 earthquakes with small-to-moderate magnitude and a maximum hypocentral depth of 40 km occurred in this area. Historical catalogues reveal that the same area was affected by several strong earthquakes such as the Mw = 6.1 event in April 1978 and the Mw = 6.2 one in March 1786 which have caused severe damages in the surrounding localities. The main seismotectonic feature affecting this area is represented by a NNW–SSE trending right-lateral strike-slip fault system called ‘‘Aeolian–Tindari–Letojanni’’ (ATLFS) which has been interpreted a…
Sensitivity of the atmospheric temperature profile to the aerosol absorption in the presence of dust
2014
Abstract Radiative transfer simulations in the shortwave (SW) and longwave (LW) spectral regions have been carried out to investigate the time evolution of the atmospheric heating/cooling rates and their influence on the temperature profiles under different vertical distributions of the aerosol absorption. The case study is based on measurements made at Rome, Italy, on 20 June 2007, when a dust layer was present above the urban boundary layer (BL) and the column aerosol optical depth at 550 nm was about 0.37. Column-integrated aerosol optical depth and single scattering albedo, as well as vertical profiles of aerosol extinction and meteorological variables have been derived from observation…
Comparison of the facial profile attractiveness in Class III borderline patients after surgical or compensatory orthodontic treatment
2020
Background This study aimed to compare the facial profile attractiveness of Class III borderline patients after surgical or compensatory orthodontic treatment. Material and Methods The sample consisted of 60 borderline Class III malocclusion patients, divided into two groups: Group 1 (Surgical): 30 patients (16 male; 14 female) treated with orthodontic fixed appliances and bimaxillary orthognathic surgery. Mean initial age was 20.05 years (s.d.=2.40) and mean treatment time was 2.23 years (s.d.=0.82). Group 2 (Compensatory): 30 patients (13 male; 17 female) treated compensatorily with fixed appliances and Class III elastics. Mean initial age was 18.53 years (s.d.=4.35) and mean treatment ti…
Using continuous user authentication to detect masqueraders
2003
Nowadays computer and network intrusions have become more common and more complicated, challenging the intrusion detection systems. Also, network traffic has been constantly increasing. As a consequence, the amount of data to be processed by an intrusion detection system has been growing, making it difficult to efficiently detect intrusions online. Proposes an approach for continuous user authentication based on the user’s behaviour, aiming at development of an efficient and portable anomaly intrusion detection system. A prototype of a host‐based intrusion detection system was built. It detects masqueraders by comparing the current user behaviour with his/her stored behavioural model. The m…
Neuropsychological Profile, Emotional/Behavioral Problems, and Parental Stress in Children with Neurodevelopmental Disorders
2021
Background: The aim of our study was to trace a specific neuropsychological profile, to investigate emotional-behavioral problems and parental stress in children with Autism Spectrum Disorder Level 1/High functioning (ASD-HF), Specific Learning Disorders (SLD) and Attention Deficit/Hyperactivity Disorder (ADHD) disorders and to highlight similarities and differences among the three groups. Methods: We retrospectively collected the data from a total of 62 subjects with ASD-HF (n = 19) ADHD (n = 21), SLD (n = 22) and 20 typical development. All the participants underwent neuropsychological standardized test for the evaluation of cognitive profile (Wechsler Intelligence Scale for Children Four…