Search results for "PROFILE"

The Challenge of Using CB-HSCs As Source for Gene Therapy: Lentiviral Vector Transduction, Phenotypic Characterization and Global Gene Expression Pro…

2015

Abstract Introduction: Genetic modification of autologous hematopoietic stem and progenitor cells (HSPC) is a promising clinical intervention to cure inherited monogenic diseases. Successful gene therapy trials have already been conducted using CD34+ cells from bone marrow and from mobilized peripheral blood. In this regard, cord blood (CB) represents an attractive source of HSCs due to its high concentration of high proliferative HSPC and increased susceptibility to be transduced by lentiviral vectors. Unfortunately, the major disadvantage is the limited number of HSC in the CB collection. Consequently, ex-vivo expansion of CB-HSC is desirable to extend clinical applications. Purposes: To …

Automated simultaneous triple dissolution profiles of two drugs, sulphamethoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosag…

2003

This article deals with the simultaneous determination of three dissolution profiles with the aid of the new and emerging continuous-flow methodology known as multicommutation. This methodology is based on a flow network of a set of solenoid valves controlled by the computer and acting as independent multicommutators to allow the easy and automated control of flowing solutions. The obtained three dissolution profiles from one dosage form are the whole formulation profile or "global profile" recommended by pharmacopoeias, and, at same time, are recorded two "individual" profiles from two drugs present in the formulation. This is the second attempt to obtain simultaneously three dissolution p…

La qualità inclusiva della scuola: dalle pratiche didattiche al profilo del docente inclusivo

2018

L’attenzione della ricerca pedagogica e didattica si rivolge con sempre maggiore consapevolezza ai fattori chiave dei processi di inclusione: la formazione degli insegnanti, lo sviluppo ed il monitoraggio dei contesti educativi nonché la produzione e l’incremento di pratiche didattiche inclusive. Attraverso la ricerca si sono voluti mettere a fuoco tali fattori chiave con la redazione di appositi strumenti che ne permettessero il controllo e la valutazione. Questo lavoro documenta una ricerca della durata di tre anni che ha visto coinvolti docenti in servizio, docenti in formazione frequentanti il terzo anno del corso di Laurea in Scienze della Formazione Primaria e alunni della scuola pri…

Privacy in Social Network Sites

2011

Are we running out of privacy? Nowadays, for example, we are concerned about whether the maintenance of a private sphere in online environments has become a luxury commodity (Papacharissi 2009). Questions of this kind are justified as online communication plays an increasingly important role in people’s everyday life (cf., e.g., Lundby 2009). While it seems exaggerated to stigmatize today’s youth as “communication junkies” (Patalong 2010), online conversations are increasingly becoming a functional equivalent to face to face communication (Beer 2008). However, some significant differences between online and “offline” communication remain. Face to face communication may remain largely intima…

Using UDDI for Publishing Metadata of the Semantic Web

2006

Although UDDI does not provide support for semantic search, retrieval and storage, it is already accepted as an industrial standard and a huge number of services already store their service specifications in UDDI. Objective of this paper is to analyze possibilities and ways to use UDDI registry to allow utilization of meta-data encoded according to Semantic Web standards for semantic-based description, discovery and integration of web resources in the context of needs of two research projects: “Adaptive Services Grid” and “SmartResource”. We present an approach of mapping RDFS upper concepts to UDDI data model using tModel structure, which makes possible to store semantically annotated reso…

Crystallite size of kaolinites as indicator of different geochemical types of bauxite

2009

A simple microstructural X-ray diffraction analysis using the Voigt function method reveals differences between bauxite deposits in the Iberian Range – Catalanides area (NE, Spain). The highest values of apparent crystallite sizes, measured by volume weighted Dv values from 001 kaolinite reflection, have been found in bauxites of type 1.

Integration Issues of Distributed Generators Considering Faults in Electrical Distribution Networks

2014

In the recent years there is a great interest in integration of distributed generation (DG) units at distribution level; this integration leads to planning as well as operational challenges. Some possibilities to handle grid planning issues are addressed in this paper. Effects on grid protection, fault current level, and voltage profile are investigated and described for different types of DG units; the classification of DG units is based on their terminal characteristics in terms of real and reactive power delivering capability. Different scenarios for mis-coordination problems caused by DG interconnection are discussed. The effect of the DG on the voltage profile of a distribution network…

Determinants of Individual Investment Decisions in Investment-Based Crowdfunding

2017

We investigate determinants of investment decisions in investment-based (equity and real estate) crowdfunding, using a novel investment-, investor- and campaign-level database. We find that this market is a man's world, with nearly 93% of investments made by men. Consistent with behavioral and finance theories, we find that women invest less in the riskiest investments but more in safer ones. Further analyses show that these findings are better explained by differences in risk aversion than differences in overconfidence between men and women. Investors located in an area considered more "sociable" (socially friendly) also invest more, but only if the investor is a woman. Overall, the findin…

NOVEL TOOLS FOR THE MECHANICAL ANALYSIS OF THIN PLATES AND RELEVANCE ON MEMBRANE-BASED TECHNOLOGIES

2020

Long-ranged and soft interactions between charged colloidal particles induced by multivalent coions

2015

Forces between charged particles in aqueous solutions containing multivalent coions and monovalent counterions are studied by the colloidal probe technique. Here, the multivalent ions have the same charge as the particles, which must be contrasted to the frequently studied case where multivalent ions have the opposite sign as the substrate. In the present case, the forces remain repulsive and are dominated by the interactions of the double layers. The valence of the multivalent coion is found to have a profound influence on the shape of the force curve. While for monovalent coions the force profile is exponential down to separations of a few nanometers, the interaction is much softer and lo…