Search results for "PROGRAM"

Ancova metode ar pielietojumu biostatistikā

2019

Šajā darbā tiks apskatīta mūsdienās lielu nozīmi ieguvusī ANCOVA metode, kuru izmanto medicīniskos pētījumos. Īss ieskats tiek aplūkots divām metodēm-ANOVA metodei un lineārajai regresijai,lai saprastu kā ANCOVA metode tika izveidota. Tas ir ļoti nozīmīgi, jo tās veido ANCOVA metodi. Kā arī teorijas beigās apskata ANCOVA metodi. Metodi pielietojot jāpārbauda dažādi nosacījumi, tāpēc tika izveidots algoritms, kas spēj apvienot visas nepieciešamās darbības, kā arī tiek pievienots R programmas kods. Darba nobeigumā tiks apskatīti arī praktiski piemēri, kuri spēs parādīt tās nozīmīgumu reālās dzīves situācijās.

La Cultura se muere : ¡Vivan las Artes!

2002

La dimensión cívica de las artes

2002

Direct Reprogramming of Somatic Cells into Induced Neuronal Cells: Where We Are and Where We Want to Go

2014

Direct reprogramming of somatic cells has emerged as a novel strategy to generate neurons, including those of human origin. The method provides enormous potential for studying the mechanisms directing neuronal differentiation, the modeling of neurodegenerative diseases, and the development of potential novel approaches for brain repair. In this chapter, we briefly trace the history of reprogramming, as well as the strategies employed to date for converting different types of somatic cells, including fibroblasts, hepatocytes, astrocytes, and pericytes into induced neuronal cells of different subtype identity. Reprogramming involves particular emphasis on transcriptional and posttranscription…

Magic triangular and tetrahedral clusters

1997

Using the methods of density functional theory and the jellium model we show that clusters with triangular [in two dimensions (2D)] or tetrahedral [in three dimensions (3D)] shapes have a strong shell structure and enhanced stability. Moreover, the shell closings correspond to the lowest magic numbers of a 2D and 3D harmonic oscillator and at the same time to the number of divalent atoms in close-packed triangles and tetrahedrons. Ab initio molecular dynamics simulations for Na and Mg clusters support the results of the jellium model.

Machine learning of microbial interactions using abductive ILP and hypothesis frequency/compression estimation

2021

Interaction between species in microbial communities plays an important role in the functioning of all ecosystems, from cropland soils to human gut microbiota. Many statistical approaches have been proposed to infer these interactions from microbial abundance information. However, these statistical approaches have no general mechanisms for incorporating existing ecological knowledge in the inference process. We propose an Abductive/Inductive Logic Programming (A/ILP) framework to infer microbial interactions from microbial abundance data, by including logical descriptions of different types of interaction as background knowledge in the learning. This framework also includes a new mechanism …

Apprentissage automatique de réseaux d'interaction à partir de données de séquences de nouvelle génération

2022

Climate change and other human-induced processes are modifying ecosystems, globally, at an ever increasing rate. Microbial communities play an important role in the functioning ecosystems, maintaining their diversity and services. These communities are shaped by the different abiotic environmental effects to which they are subjected and the biotic interactions between all community members. The ANR Next-Generation Biomonitoring (NGB) project proposed to reconstruct interaction networks from abundance measures obtained sequencing environmental DNA (eDNA) and to use these networks to monitor ecosystem change. In this thesis, conducted as part of the NGB project, I evaluate the potential of tw…

Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

2021

Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-dependent drug absorption, which may be sensitive to intestinal anatomic changes during bypass surgery, including Roux-en-Y gastric bypass (RYGB). Previous computer simulation data indicate increased metformin absorption after RYGB. In this study, we experimentally determined the region-dependent permeability of metformin, using the rat single-pass intestinal perfusion method (SPIP), which we then imp…

From Graz to Göttingen: Neugebauer’s Early Intellectual Journey

2016

Otto Neugebauer’s early academic career was marked by a series of transitions. His interests shifted from physics to mathematics, and finally to the history of ancient mathematics and exact sciences. Yet even from his early years in Graz, Neugebauer was strongly attracted to the mathematical culture of Gottingen. When he arrived there in 1922, he quickly established a strong personal friendship with Richard Courant, the newly appointed Director of the Mathematics Institute. Neugebauer and Courant worked together closely up until 1933, when the Nazi government decimated the Gottingen scientific community. In this essay, Neugebauer’s historical work and his vision for a new approach to the st…

Learning strategies. A training programme

2001

We elaborated and applied a training programme to teach learning strategies to students in continuing adult education courses in Valencia (Spain) throughout an academic year. We worked with one control group and with one experimental group. These groups were equivalent in terms of pre-test assessments and there was not any significant difference of means either in learning strategies or in marks in Spanish and Maths. We found significant difference of means in the post-test, after the training programme, in learning strategies, and also an important difference in marks. Experimental students improved their learning strategies significantly along with their marks in Spanish and Maths, wherea…