Search results for "PROGRESS"

Algunas notas a Mosquión (fg. 6 N/S) sobre la idea de progreso

2008

Antonio.Melero@uv.es El propósito del presente trabajo es el de pasar revista al fragmento mayor de Mosquión a fin de estudiar su importancia para el estudio del concepto griego de progreso. This paper aims to review, from a stylistic and narrative perspective, Moschion’s main fragment in order to establish his relevance for the study of the Greek concept of progress.

Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.

2014

Given our interest in finding potential antitumor agents and in view of the multifactorial mechanistic nature of cancer, in the present work, taking advantage of the multifunctional ligands approach, new chimeric molecules were designed and synthesized by combining in single chemical entities structural features of SAHA, targeting histone deacetylases (HDACs), with substituted stilbene or terphenyl derivatives previously obtained by us and endowed with antiproliferative and pro-apoptotic activity. The new chimeric derivatives were characterized with respect to their cytotoxic activity and their effects on cell cycle progression on different tumor cell lines, as well as their HDACs inhibitio…

Primary Progressive and progressive relapsing multiple sclerosis show different clinical and instrumental findings and disability progression? A comp…

2013

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related d…

2022

Abstract Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part. Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000–2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing–remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers’ characteristics, geographic macro-ar…

Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register.

2022

Background: Definitions for reliable identification of transition from relapsing-remitting multiple sclerosis (MS) to secondary progressive (SP)MS in clinical cohorts are not available. Objectives: To compare diagnostic performances of two different data-driven SPMS definitions. Methods: Data-driven SPMS definitions based on a version of Lorscheider’s algorithm (DDA) and on the EXPAND trial inclusion criteria were compared, using the neurologist’s definition (ND) as gold standard, in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Akaike information criterion (AIC) and area under the curve (AUC). Results: A cohort of 10,240 MS patients wi…

Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

2020

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit an…

Progression is independent of relapse activity in early multiple sclerosis: a real-life cohort study

2022

Portaccio et al. report that in early relapsing-onset multiple sclerosis, progression independent of relapse activity is an important contributor to disability accumulation. Insidious progression occurs even in the earliest disease phases, suggesting that inflammation and degeneration may represent a single disease continuum.Disability accrual in multiple sclerosis may occur as relapse-associated worsening or progression independent of relapse activity. The role of progression independent of relapse activity in early multiple sclerosis is yet to be established. The objective of this multicentre, observational, retrospective cohort study was to investigate the contribution of relapse-associa…

L'ornementation des bracelets de l'âge du Bronze européen : analyse descriptive et perspectives

2013

This paper discusses the ornamental patterns of metal bracelets worn on the arms and legs of people during the European Bronze Age. A method has been specially created to study geometric patterns. Some sets of metal bands (bracelets métalliques) of Bronze Age reach a high level of complexity due to the use of combined patterns in an overall structure. This paper deals with an experimental criterion concerning this phenomenon. The methodology, developed for the purpose i.e. the experimental criterion developed for the purpose of this study, was to extract geometric patterns from the original media. The principle is to release the geometrical compositions of the deformations induced by the mo…

Roboti : "Es, topošais pilsonis" mācību resursi

2023

Izdevums "Es, topošais pilsonis" ir metodisks līdzeklis ekonomikas, pilsoniskās izglītības un ētikas mācību satura apguvei starpdisciplinārā pieejā, kas izstrādāti Erasmus+ KA2 projekta I, Citizen to Be ietvaros. Projekta materiāli sastāv no 12 nodarbībām: personība, nabadzība, roboti, ekoloģija, patērētājs, brīvprātīgais darbs, sociālie tīkli, viltus ziņas, darbs, veselība, maiņa, uzņēmējdarbība. Katra nodarbība ir sagatavota tā, lai tā atbilstu skolēnu vecuma grupai, kā arī sociālajai un kognitīvajai attīstībai. Katrai nodarbībai tiek piedāvāts ieteicamais mācību procesa apraksts, kas ietver 3 vai vairāk fragmentus. Katrā nodarbībā tiek aktualizēta konkrēta tēma, kas atspoguļo personīgo v…

EUROPEAN CONVERGENCE AND ITS IMPACT ON THE SOCIAL STRATEGY OF LATVIA

2014

The purpose of this study is to introduce evaluation of convergence policy activities in the European Union and to designate social development trends of Latvia in the context of reaching the goals of strategy “Europe 2020. The aim of the research has set the following tasks: to introduce the main EU social convergence theory investigations as the development challenges for improvement socio-economic well-being of the EU states; to evaluate current social situation and eventual social strategy of Latvia on 2014-2020; to estimate European convergence policy impact on the social development of Latvia. The strategic goals of EU policy are discussed as well as the development challenges for imp…