Search results for "PROGRESS"
showing 10 items of 1620 documents
REVOLUTION AND PROGRESS IN KANTIAN REASON
2022
Immanuel Kant’s project for a critique of reason exhibits a foundation that has an avowedly not despotic profile. This is to say that the sense in which Kant speaks of reason as a faculty of principles appears to be intimately connected with the idea that ‘principle’, in a strict sense, can only be said of what does not escape the critical opinion and autonomy of thought that such a judgment necessarily involves. The strictly political form of government that is applied, according to Kant, to the authority of reason as exercise of non-despotic power affords a privileged point of view from which to reread, in not necessarily antagonistic terms, a widespread image in contemporary debate – tha…
Dall'identità all'armonia. Umanismo, progresso tecnico e idea di Europa
2016
Forse il percorso che porta dal pensiero dell’identità alla filosofia dell’armonia è l’ultimo ed anche il più difficile tratto di cammino che l’uomo delle società tecnologicamente avanzate, unificate nel pianeta dai mezzi di comunicazione istantanea, deve percorrere per uscire dalla disumanità del capitalismo indifferente e della dissacrazione della dimora naturale, e per entrare nella fraternità fra tutte le persone – gli individui geneticamente e naturalmente appartenenti alla specie umana – e nella cultura della cura e della custodia della Terra, per tutte le specie che la coabitano.
Responsabilità e progresso. Jonas, Apel e il futuro globale
2022
The essay discusses the foundations of the ethics of responsibility, comparing the positions of Jonas and Apel. In particular, it focuses on the relationship between technology and progress. The author evaluates Jonas’ ethics as insufficient in terms of the theory of justice. Preserving the natural should not be separated from the idea of progress. Instead, planetary macroethics should activate the socio-political conditions for the discursive realisation of global responsibility. The ethics of responsibility is connected to the ethics of progress for the realisation of the conditions of human dignity.
The Effects of Short-Term Personal Goals on Subjective Well-Being
2015
Several studies demonstrated that subjective well-being is associated with goal value and perceived progress but their validity is affected by methodological biases. Moreover, a few have analysed the influence of short-term goals. We aimed to analyse how the levels of and changes in short-term goals progress and value influence subsequent levels of and changes in subjective well-being. This study adopted a three-wave longitudinal design with one-month intervals. Four hundred nine participants (186 males; age 19–71) reported their subjective well-being and their two most important goals and rated each over time in terms of value and progress. A latent difference score model revealed that lev…
Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis
2011
It is well established that physically fit individuals have a reduced risk of developing CVD (cardiovascular disease) and other age-related chronic disorders. Regular exercise is an established therapeutic intervention with an enormous range of benefits. Chronic low-grade systemic inflammation may be involved in atherosclerosis, diabetes and in pathogenesis of several chronic pathological conditions; recent findings confirm that physical activity induces an increase in the systemic levels of a number of cytokines and chemokines with anti-inflammatory properties. The possibility that regular physical exercise exerts anti-inflammation activity, being the interaction between contracting muscle…
Pathogenetic Mechanisms of Hypertension-Brain-Induced Complications: Focus on Molecular Mediators.
2021
There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may manifest as stroke, subclinical cerebrovascular abnormalities and cognitive decline. The pathophysiological mechanisms of these harmful effects remain to be completely clarified. Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation. In the last several years, new possible mechani…
UN ELEVATO RAPPORTO NEUTROFILI-LINFOCITI AUMENTA IL RISCHIO DI EVENTI CARDIOVASCOLARI E DI DECLINO DELLA FUNZIONE RENALE IN UNA COORTE DI PAZIENTI IP…
2022
Scopo dello studio: Numerosi studi epidemiologici hanno evidenziato come l’infiammazione cronica low-grade, stimata attraverso il rapporto neutrofili-linfociti (NLR), sia collegata ai fattori di rischio cardiovascolari tradizionali e non. Scopo del nostro studio è stato quello di indagare sul potenziale ruolo prognostico del NLR riguardo la progressione della malattia renale cronica e l’insorgenza di eventi cardiovascolari avversi in una coorte di pazienti nefropatici e ipertesi. Materiali e metodi: In questo studio retrospettivo osservazionale sono stati consecutivamente selezionati 403 pazienti i nostri ambulatori di Nefrologia e Ipertensione. Ogni paziente è stato sottoposto a esame ob…
An Elevated Neutrophil-Lymphocyte Ratio Increases the Risk of Cardiovascular Events and of Renal Function Decline in Hypertensive Patients with CKD
2021
Introduction: Many epidemiological studies have shown that low-grade chronic inflammation, estimated through the neutrophil-lymphocyte ratio (NLR), is linked to traditional and non-traditional cardiovascular (CV) risk factors. Aim: The aim of our study was to investigate the potential prognostic role of NLR regarding the progression of chronic kidney disease (CKD) and the development of CV events in a cohort of renal and hypertensive patients. Methods: In this retrospective observational study, 403 patients consecutively attending our Nephrology and Hypertension clinics were included. At the baseline observation and control visits in all patients, in addition to the clinical-anamnestic eval…
Lévi-Strauss.L'illusione del progresso e la fine della storia
2011
Lévi-Strauss considera il progresso alla stregua di un mito moderno. Il saggio esamina criticamente la connessione tra la dinamicità del progresso e l'entropia storica.
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
2020
AbstractCutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5′-phosphatase-like protein-1 (INPPL1) and BTB/POZ Domain-Containing Protein 3 (BTBD3). INPPL1 and BTBD3 were downregulated when melanoma cells expressed miR-205, indicating that these genes…