Search results for "PROGRESS"

Radioaktivitāte

2023

Mācību grāmatas mērķis ir iepazīstināt lasītāju ar radioaktivitātes fenomenu, jautājumiem par atoma kodola stabilitāti, radioaktīvo elementu, starojuma iedarbību un izmantošanas iespējām. --///-- Šis ir nekomerciāls izdevums, un visi ievietotie attēli ir tikai iepazīšanās,mācīšanās un pētniecības mērķiem, tādi, kurus neaizsargā autortiesības (Public Domain) vai arī kuru autori tos klasificējuši atbilstoši CC BY-NC-SA 4.0 licences lietojumam.

Microradiography and confocal laser scanning microscopy applied to enamel lesions formed in vivo with and without fluoride varnish treatment

1996

The aim of the present investigation was to combine 2 techniques suitable for lesion characterization: quantitative microradiography (TMR) and confocal laser scanning microscopy (CLSM) on in vivo induced lesions with and without a fluoride varnish (Duraphat(R)) treatment. Orthodontic bands were attached to premolars to be extracted for orthodontic reasons to induce enamel caries on the buccal surfaces. In the caries development part of the study, 1 tooth of each pair received at the start 1 topical application with the fluoride varnish Duraphat(R), the contralateral tooth serving as untreated control. All teeth were extracted after 4 weeks. In the caries progression part, the premolars were…

Comparison of global visual field indices (MD,VFI), GPA II change and cluster analysis of visual field progression in glaucoma

2014

2021

While the importance of the iron-load of lipocalin-2 (Lcn-2) in promoting tumor progression is widely appreciated, underlying molecular mechanisms largely remain elusive. Considering its role as an iron-transporter, we aimed at clarifying iron-loaded, holo-Lcn-2 (hLcn-2)-dependent signaling pathways in affecting renal cancer cell viability. Applying RNA sequencing analysis in renal CAKI1 tumor cells to explore highly upregulated molecular signatures in response to hLcn-2, we identified a cluster of genes (SLC7A11, GCLM, GLS), which are implicated in regulating ferroptosis. Indeed, hLcn-2-stimulated cells are protected from erastin-induced ferroptosis. We also noticed a rapid increase in rea…

Decreased Paraoxonase-2 Expression in Human Carotids During the Progression of Atherosclerosis

2008

Objective— Many gene products involved in oxidation and inflammation are implicated in the pathogenesis of atherosclerosis. We investigated paraoxonase 2 (PON2), 5-lipoxygenase (5-LO), and 5-LO activating protein (FLAP) expression and malondialdehyde (MDA) levels in carotid lesions to assess their involvement in plaque formation. Methods and Results— We measured gene expression and MDA levels in atherosclerotic plaques from 59 patients undergoing carotid endarterectomy, and in plaque-adjacent tissue from 41/59 patients. Twenty-three fetal carotids and 6 mammary arteries were also investigated. Real-time polymerase chain reaction and immunohistochemistry revealed decreased PON2 expression i…

Statins in liver disease: not only prevention of cardiovascular events

2018

Statins are lipid-lowering agents and one of the most pre-scribed drugs worldwide. Their main mechanism of action –inhibition of the mevalonate pathway through an effect on hydroxy-methylglutaryl CoA reductase, thus affecting the synthesis of cholesterol in the liver – makes this class of drugs pivotal in primary and secondary prevention of cardio-vascular risk, as extensively demonstrated in large prospective, randomized controlled trials. Along the years, we learned that the lower the better, and LDL-cholesterol targets have been progressively reduced to values ≤70 mg/dL for secondary prevention or in the presence of diabetes.

Didactologies/didactique des langues-cultures et didactique de la musique du français: réflexion (s) en 2016

2016

Revenant aux sources de définitions de la Didactologie/didactique des languescultures élaborées par Robert Galisson dans les années 1985-1986 en particulier, on constate que le paysage didactique actuel est fortement marqué par la prépondérance du recours à divers modes d’application relativement contrôlables, alors que l’on aurait pu croire que cette tendance était de nos jours révolue. Cette démarche permet également de remarquer l’aide apportée par Robert Galisson pour la démonstration de la légitimité de la Didactique de la musique du français (1996) à une époque où le Cadre européen commun de référence pour les langues n’était pas encore paru ni appliqué. Ces rétrospections sont l’occa…

Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.

2021

Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure. In AHF syndromes, CA125 is strongly associated with right-sided heart failure parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated H…

Tutkiva oppiminen : tapaustutkimus menetelmän sovelluksesta peruskoulun 4. luokan opiskeluun

2008

Predicting Mortality Risk in Patients With Compensated HCV-Induced Cirrhosis: A Long-Term Prospective Study

2009

OBJECTIVES: The identification of prognostic factors associated with mortality is crucial in any clinical setting. METHODS: We enrolled in a prospective study 352 patients with compensated hepatitis C virus (HCV)-induced cirrhosis, consecutively observed between 1989 and 1992. At entry, patients underwent upper endoscopy to detect esophageal varices, and were then surveilled by serial clinical and ultrasonographic examination. The model for end-stage liver disease (MELD) score was calculated with information collected at enrollment. Baseline predictors and intercurrent events associated with mortality were assessed using the Cox regression model. RESULTS: During a median follow-up of 14.4 y…