Search results for "PROGRESS"
showing 10 items of 1620 documents
Kant’s Idea of History
2016
Is there a philosophy of history in Kant’s work? What does “philosophy of history” mean in relation to Kant? In what sense can one use this expression, especially in relation to the Kantian concept of philosophy? The essay tries to answer these questions examining the relationship between biology, progress and political order in Kant's rational reading of human events.
La questione del soprasensibile nella Preisschrift sui progressi della metafisica di Immanuel Kant
2011
Questo saggio intende mettere in evidenza, a partire da una lettura della Preisschrift über die Fortschritte der Metaphysik, il senso architettonico che la metafisica assume in Kant: la metafisica non lega la sua prestazione più eminente al possesso dogmatico di un dominio, sia esso quello teoretico degli oggetti della natura o anche quello pratico degli oggetti della morale, ma alla possibilità di illuminare la strada per il passaggio dall'uno all'altro ambito del conoscere, in una prospettiva critica che, se da un lato mette in rilievo i pericoli insiti negli eccessi dogmatici della ragione, dall'altro ricusa tuttavia l'idea di una metafisica del soprasensibile concepita sotto il segno di…
Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma…
1998
The role of Transforming growth factor beta (TGF-beta) in carcinogenesis is complex. There are reports on both tumor inhibition and tumor promotion by TGF-beta. To elucidate the complex role of TGF-beta in epithelial carcinogenesis, we generated transgenic mice overexpressing a dominant negative type II TGF-beta receptor in the basal cell compartment and in follicular cells of the skin. Despite the reduced responsiveness of transgenic keratinocytes to TGF-beta, both proliferation and differentiation were normal in non-irritated epidermis of these transgenic mice. Thus, interruption of signaling of all three isoforms of TGF-beta in basal and follicular cells does not disturb tissue homeostas…
Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19)
2020
Abstract Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory disease, which can evolve into multi-organ failure (MOF), leading to death. Several biochemical alterations have been described in COVID-19 patients. To date, many biomarkers reflecting the main pathophysiological characteristics of the disease have been identified and associated with the risk of developing severe disease. Lymphopenia represents the hallmark of the disease, and it can be detected since the early stage of infection. Increased levels of several inflammatory biomarkers, including c-reactive protein, have been found in COVID-19 patients and associ…
Value of Deoxyribonucleic Acid Ploidy and Nuclear Morphometry for Prediction of Disease Progression in Renal Cell Carcinoma
1996
AbstractPurpose: A retrospective study was performed on 108 patients with localized renal cell carcinoma (pT1 to 3a N0M0) to determine whether ploidy and nuclear morphometry are independent predictive factors in addition to stage and grade.Materials and Methods: Deoxyribonucleic acid (DNA) content was analyzed by flow cytometry and nuclear morphometry characterized by 5 nuclear descriptors. A Cox proportional hazards regression model was used to identify significant prognostic factors for disease progression.Results: A model combining tumor stage and grade, DNA ploidy and nuclear minor axis was chosen as optimal with risk of disease progression increased with increasing tumor stage and grad…
PeerLA - Assistant for Individual Learning Goals and Self-Regulation Competency Improvement in Online Learning Scenarios
2016
While online learning is already a part of university education and didactics, not all students have the necessary self-regulation competency to really learn on their own efficiently and effectively. In classroom a teacher can take over a moderating part, set intermediate goals and give feedback to one's progress, but participants of online learning courses (e.g. in blended scenarios or Massive Open Online Courses (MOOCs)) face a higher demand of self-regulation competency. This paper presents a course and content independent assistant, PeerLA, which assists in improving self-regulation competency. PeerLA allows setting of long-term goals, breakdown into intermediate goals and keeps track o…
Students’ online information use and learning progress in higher education – A critical literature review
2021
Learning using the Internet has become a vital factor for academic success in higher education. Students increasingly rely on the Internet as their main information source. However, related researc...
Aprender y argumentar España. La visión de la identidad española entre el alumnado al finalizar el bachillerato
2012
Este trabajo forma parte de un estudio más amplio sobre la progresión del aprendizaje de la identidad nacional entre alumnado español de secundaria a partir del actual marco curricular y los libros de texto mayoritarios. Aquí se presentan los resultados provisionales de un análisis empírico de la visión del alumnado sobre la identidad española al acabar bachillerato y su capacidad de argumentar al respecto. Se ha realizado a partir de una muestra de cuestionarios y ejercicios de argumentación en un centro de secundaria This paper is part of a wider study on the learning progression of the national identity among students of spanish secondary from the current curriculum framework and the maj…
Distinct Roles for IL-1 Receptor Type I Signaling in Early Versus Established Leishmania major Infections
2006
IL-1alpha/beta released by infected dendritic cells (DC) plays a critical role in the development of protective immunity against Leishmania major. Previous studies demonstrated that treatment of susceptible BALB/c mice with IL-1alpha during T-cell priming (days 1-3 post-infection) induced T helper (Th)1-mediated protection. In contrast, we now demonstrate that prolonged treatment with IL-1alpha (for 3 weeks) worsened disease outcome. To characterize the receptor involved, L. major infections in IL-1 receptor type I (IL-1RI) knockout mice were studied. In C57BL/6 IL-1RI-/- mice, the IL-1alpha-mediated protective effect was abrogated. The course of high-dose infection (2 x 10(5) parasites) in…
Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.
2006
Abstract Purpose: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether the leptin system could become a target in breast cancer therapy, we examined the expression of leptin and its receptor (ObR) in primary and metastatic breast cancer and noncancer mammary epithelium. We also studied whether the expression of leptin/ObR in breast cancer can be induced by obesity-related stimuli, such as elevated levels of insulin, insulin-like growth factor-I (IGF-I), estradiol, or hypoxic conditions. Experimental Design: The expression of leptin and ObR was examined by immunohistochemistry…