Search results for "PROSPECTIVE COHORT"

showing 10 items of 1731 documents

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflamma…

2013

Maria D Pinazo-Durán,1,* Carmen Galbis-Estrada,1,* Sheila Pons-Vázquez,1 Jorge Cantú-Dibildox,2 Carla Marco-Ramírez,1 Javier Benítez-del-Castillo21Ophthalmic Research Unit Santiago Grisolia, Department of Surgery/Ophthalmology, Faculty of Medicine, University of Valencia, Valencia, Spain; 2Department of Ophthalmology, Hospital of Jerez, Jerez de la Frontera, Spain*These authors contributed equally to this workBackground: Women, and those older than 65 years of age, are particularly susceptible to dry eye disorders (DEDs). Inflammation is clearly involved in the pathogenesis of DEDs, and there is mounting evidence on the antioxidant and …

AdultMaleVascular Endothelial Growth Factor Amedicine.medical_specialtyessential polyunsaturated fatty acidsInterleukin-1betaInflammationnutraceuticsGastroenterologyAntioxidantsPathogenesischemistry.chemical_compoundRisk FactorsInternal medicineFatty Acids Omega-3HumansMedicineProspective StudiesInterleukin 6Prospective cohort studyAgedOriginal ResearchAged 80 and overchemistry.chemical_classificationbiologyInterleukin-6business.industryagingtearsInterleukinGeneral MedicineMiddle AgedcytokinesInterleukin-10Vascular endothelial growth factorchemistryClinical Interventions in AgingDietary SupplementsImmunologybiology.proteinTearsDry Eye SyndromesFemalewomenInflammation MediatorsGeriatrics and Gerontologymedicine.symptombusinessPolyunsaturated fatty acidClinical Interventions in Aging
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Application of a capsaicin rinse in the treatment of burning mouth syndrome

2010

Objective: To examine the efficacy of a new topical capsaicin presentation as an oral rinse in improving the symptoms of burning mouth syndrome (BMS). Study design: A prospective, double-blind, cross-over study was made of 30 patients with BMS. There were 7 dropouts; the final study series thus comprised 23 individuals. The patients were randomized to two groups: (A) capsaicin rinse (0.02%) or (B) placebo rinse, administered during one week. After a one-week washout period, the patients were then assigned to the opposite group. Burning discomfort was scored using a visual analog scale (VAS): in the morning before starting the treatment, in the afternoon on the first day of treatment, and at…

AdultMaleVisual analogue scaleAdministration TopicalMouthwashesBurning Mouth SyndromePlaceboOdontologialaw.inventionchemistry.chemical_compoundRandomized controlled trialDouble-Blind MethodlawMedicineHumansProspective StudiesProspective cohort studyGeneral DentistryMorningAgedAged 80 and overCross-Over StudiesOral Medicine and Pathologybusiness.industryBurning mouth syndromeMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Crossover studyOtorhinolaryngologychemistryCapsaicinAnesthesiaUNESCO::CIENCIAS MÉDICASEstomatologiaSensory System AgentsSurgeryFemaleResearch-Articlemedicine.symptomCapsaicinbusinessCremades
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The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the S…

2018

Inorganic arsenic exposure is ubiquitous, and both exposure and interindividual differences in its metabolism have been associated with cardiometabolic risk. However, the associations of arsenic exposure and arsenic metabolism with the metabolic syndrome (MetS) and its individual components are relatively unknown. We used Poisson regression with robust variance to evaluate the associations of baseline arsenic exposure (urinary arsenic levels) and metabolism (relative percentage of arsenic species over their sum) with incident MetS and its individual components (elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, hypertension, and elevated fast…

AdultMaleWaistDiabetes riskEpidemiologyOriginal Contributionschemistry.chemical_elementPhysiology010501 environmental sciences01 natural sciencesArsenicMidwestern United States03 medical and health sciencesYoung Adult0302 clinical medicinemedicineHumans030212 general & internal medicineProspective StudiesProspective cohort studyArsenic0105 earth and related environmental sciencesMetabolic SyndromeArsenic toxicitybusiness.industryArizonaEnvironmental exposureEnvironmental ExposureMiddle Agedmedicine.diseasechemistryIndians North AmericanFemaleMetabolic syndromebusinessCohort study
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Combined effects of shiftwork and individual working time control on long-term sickness absence: a prospective study of finnish employees

2014

Objective To investigate whether the effects of shiftwork on long-term sickness absence vary according to the level of individual working time control (WTC). Methods A representative sample of Finnish employees (1447 men and 1624 women) was combined with a register-based follow-up. A negative binomial model was used in the analysis of long-term sickness absence days. The results were adjusted for various background and work-related factors. Results Individual WTC decreased long-term sickness absence. The higher rate of sickness absences in shiftwork was mainly due to the lower level of WTC. Working time control decreased sickness absence equally in day work and shiftwork. Conclusions The ne…

AdultMaleWorkAdolescentControl (management)Young AdultNursingRisk FactorsEnvironmental healthSurveys and QuestionnairesWork Schedule ToleranceAbsenteeismMedicineHumansProspective StudiesYoung adultProspective cohort studyFinlandSickness absencebusiness.industryPublic Health Environmental and Occupational Healthta3141ta5142Middle AgedWorking timehumanitiesTerm (time)Sick leaveAbsenteeismFemaleSick LeavebusinessFollow-Up StudiesJournal of Occupational & Environmental Medicine
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Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort

2010

Phytosterol intake with natural foods, a measure of healthy dietary choices, increases plasma levels, but increased plasma phytosterols are believed to be a coronary heart disease (CHD) risk factor. To address this paradox, we evaluated baseline risk factors, phytosterol intake, and plasma noncholesterol sterol levels in participants of a case control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort who developed CHD (n = 299) and matched controls (n = 584) who remained free of CHD after a 10 year follow-up. Sitosterol-to-cholesterol ratios increased across tertiles of phytosterol intake (P = 0.026). HDL-cholesterol level increased, …

AdultMalecampesterolmedicine.medical_specialtyCampesterolPopulationCoronary DiseaseLathosterolQD415-436lathosterolBiochemistryplant sterolsCohort Studieschemistry.chemical_compoundEndocrinologyRisk FactorsInternal medicineHumansMedicineProspective StudiesRisk factoreducationProspective cohort studyAgededucation.field_of_studyCholesterolbusiness.industrycholesterolPhytosterolsCell BiologyEuropean Prospective Investigation into Cancer and NutritionMiddle AgedDietEuropean Prospective Investigation into Cancer and NutritionEndocrinologysitosterolchemistrySpainCase-Control StudiesNested case-control studyFemalelipids (amino acids peptides and proteins)Patient-Oriented and Epidemiological ResearchbusinessJournal of Lipid Research
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Gastrointestinal symptoms in infancy: A population-based prospective study

2005

Abstract Background. During the first months of life, infants can suffer from many ‘minor’ gastroenterological disturbances. However, little is known about the frequency of these problems and the factors which predispose or facilitate their onset. Aims. (a) To ascertain the frequency of the most common gastrointestinal symptoms in infants during the first 6 months after birth; (b) to evaluate the influence of some variables on the onset of the symptoms. Study design and patients. Each of the 150 paediatricians distributed throughout Italy followed 20 consecutive infants from birth to 6 months. 2879 infants (1422 f, 1457 m) concluded the study. The presence of the following symptoms was eval…

AdultMalecolic; constipation; diarrhoea; epidemiology; failure to thrive; feeding; infancy; regurgitation; vomitingPediatricsmedicine.medical_specialtyInfancySettore MED/09 - Medicina InternaConstipationColicEpidemiologyVomitingGestational AgemedicineHumansProspective StudiesProspective cohort studyHepatologybusiness.industryCryingFeedingInfant NewbornGastroenterologyInfantGestational ageFailure to thriveRegurgitationInfant Low Birth WeightInfant FormulaDiarrhoeaHospitalizationLow birth weightDiarrheaBreast FeedingItalyDiarrhea InfantileFailure to thriveGastroesophageal RefluxVomitingFemalemedicine.symptombusinessConstipationFollow-Up StudiesDigestive and Liver Disease
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Clinical impact of broad-spectrum empirical antibiotic therapy in patients with healthcare-associated pneumonia: a multicenter interventional study

2012

Healthcare-associated pneumonia (HCAP) has been proposed as a new category of pneumonia distinct from community-acquired pneumonia (CAP). A multicenter observational study in 2008 finds that patients with HCAP have a mortality rate significantly higher than patients with CAP, and a worse outcome is associated at logistic regression analysis with a low adherence to empirical antibiotic therapy recommended by ATS/IDSA guidelines. We designed a prospective interventional study to establish whether administration of a broad-spectrum antibiotic therapy consistent with the 2005 ATS/IDSA guidelines has an effect on the clinical outcome of hospitalized patients with HCAP. All patients with HCAP pro…

AdultMalecommunity-acquired pneumonia; broad-spectrum empirical therapy; healthcare-associated pneumonia; multidrug-resistant pathogens; antibiotic therapymedicine.medical_specialtyCarbapenemcommunity-acquired pneumoniaSettore MED/09 - Medicina InternaAdolescentLogistic regressionNOYoung AdultCommunity-acquired pneumoniaDrug Resistance Multiple BacterialInternal medicinePneumonia BacterialInternal Medicinemedicineantibiotic therapyHumanspneumoniaProspective StudiesYoung adultIntensive care medicineProspective cohort studyAgedAged 80 and overCross Infectionbusiness.industryMortality ratehealthcare-associated pneumoniaHealthcare-associated pneumonia Community-acquired pneumonia Antibiotic therapy Multidrug-resistant pathogens Broad-spectrum empirical therapybroad-spectrum empirical therapyLength of StayMiddle Agedmedicine.diseaseSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheAnti-Bacterial AgentsPneumoniamultidrug-resistant pathogensItalyPractice Guidelines as TopicEmergency MedicineDrug Therapy CombinationFemaleObservational studybusinessantibiotic therapy; pneumoniamedicine.drug
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Treatment of severe von Willebrand disease with a high‐purity von Willebrand factor concentrate (Wilfactin®): a prospective study of 50 patients

2007

Background and objectives: A plasma-derived von Willebrand factor (VWF) concentrate with low factor VIII (FVIII) content was specifically developed to treat von Willebrand disease (VWD). Efficacy and safety were investigated by merging the results of two comparable protocols conducted prospectively in 5 European and 12 French centers. Methods and results: Fifty patients with clinically severe VWD (72% had VWF ristocetin cofactor activity less than 10 IU dL(-1) and 46% had FVIII < 20 IU dL(-1)) were treated with the concentrate as the only therapy, except for clinical situations requiring a priming dose of FVIII to rapidly correct an intrinsic coagulation defect. A total of 139 spontaneous b…

AdultMalecongenital hereditary and neonatal diseases and abnormalitiesmedicine.medical_specialtyAdolescentHemorrhagePostoperative HemorrhageGastroenterologyVon Willebrand factorhemic and lymphatic diseasesInternal medicinevon Willebrand FactormedicineVon Willebrand diseaseHumansProspective StudiesChildProspective cohort studyAgedAged 80 and overHemostasisBleeding episodesFactor VIIIbiologybusiness.industryHematologyMiddle Agedmedicine.diseaseSurgeryClinical trialvon Willebrand DiseasesCoagulationChild PreschoolHemostasisConcomitantbiology.proteinFemaleSafetybusinessJournal of Thrombosis and Haemostasis
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A Prospective Randomized Study of Corticosteroids as Adjuvant Drugs to Opioids in Advanced Cancer Patients

2007

This randomized controlled study evaluated the role of corticosteroids as adjuvants to opioid therapy in 76 advanced cancer patients with pain who requiring strong opioids. Patients were divided in 2 groups. Group O received conventional opioid treatment. Group OS received dexamethasone (8 mg orally) along with conventional treatment. Pain and symptom intensity, sense of well-being, and opioid escalation index and distress score were recorded at weekly intervals until death. No differences in pain intensity, opioid consumption, and opioid escalation index were found in 66 patients who survived 33 to 37 days. Corticosteroids did not provide significant additional analgesia to opioids, but p…

AdultMalecorticosteroidmedicine.medical_treatmentAnti-Inflammatory Agentslaw.invention03 medical and health sciences0302 clinical medicinePharmacotherapyRandomized controlled trial030502 gerontologylawNeoplasmsmedicineHumansProspective Studiesopioids in advanced cancer patientsprospective randomized studyProspective cohort studyDexamethasoneAgedPain MeasurementAged 80 and overAnalysis of VarianceChemotherapyadjuvant drugDose-Response Relationship Drugbusiness.industryPalliative CareGeneral MedicineMiddle AgedPain IntractableAnalgesics OpioidTreatment OutcomeOpioidChemotherapy Adjuvant030220 oncology & carcinogenesisAnesthesiaDrug Therapy CombinationFemale0305 other medical scienceCancer painbusinessAdjuvantFollow-Up Studiesmedicine.drugAmerican Journal of Hospice and Palliative Medicine®
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Palliative Sedation in Patients With Advanced Cancer Followed at Home: A Prospective Study

2014

Abstract Context Home care programs in Italy. Objectives The aim of this study was to assess a protocol for palliative sedation (PS) performed at home. Methods A total of 219 patients were prospectively assessed to evaluate a PS protocol in patients with advanced cancer followed at home by two home care programs with different territorial facilities. The protocol was based on stepwise administration of midazolam. Results A total of 176 of the patients died at home, and PS was performed in 24 of these patients (13.6%). Younger patients received the procedure more frequently than older patients (P = 0.012). The principal reasons to start PS were agitated delirium (n = 20) and dyspnea (n = 4).…

AdultMaleend of lifemedicine.medical_specialtyPalliative careContext (language use)Settore MED/42 - Igiene Generale E ApplicataPalliative sedationend of life; midazolam; palliative care; Palliative sedation; Adult; Aged; Aged 80 and over; Delirium; Dyspnea; Family; Feasibility Studies; Female; Humans; Hypnotics and Sedatives; Italy; Male; Midazolam; Middle Aged; Neoplasms; Palliative Care; Patient Care Team; Prospective Studies; Terminal Care; Young Adult; Home Care Services; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous); Medicine (all)Young AdultPalliative sedationNeoplasms80 and overmedicineHumansHypnotics and SedativesFamilyIn patientProspective StudiesIntensive care medicineProspective cohort studyNursing (all)2901 Nursing (miscellaneous)General NursingAgedAged 80 and overPatient Care TeamTerminal Carepalliative carebusiness.industryMedicine (all)DeliriumMiddle AgedHome Care ServicesAdvanced cancerDistressDyspneaAnesthesiology and Pain MedicinePalliative sedation; end of life; midazolam; palliative careItalymidazolamEmergency medicineFeasibility StudiesMidazolamFemaleNeurology (clinical)businessmedicine.drugJournal of Pain and Symptom Management
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