Search results for "PROTEÍNA"
showing 10 items of 63 documents
Detección inmunohistoquímica de la proteína L1 de Virus Papiloma Humano (HPV) de alto riesgo en citologías y biopsias de cuello uterino
2005
Para confirmar la detección inmunohistoquímica de la proteína L1 de HPV de alto riesgo, tanto en citologías con anormalidades en células epiteliales como en biopsias con diagnóstico de carcinoma epidermoide cervical, se seleccionaron aleatoriamente: 11 citologías cervicales del año 2004 con interpretación citológica de anormalidades en células escamosas incluyendo: células escamosas atípicas y lesión intraepitelial escamosa de bajo y alto grado y 50 biopsias de cérvix con carcinoma epidermoide diagnosticados entre los años 1950 y 1980. Todas las muestras, tanto citológicas como histológicas fueron sometidas al procedimiento inmunohistoquímico para la detección de la proteína L1 de HPV de al…
Bases estructurales de la regulación por nitrógeno mediada por la proteína señalizadora PII
2016
Tesis doctotal, 272 páginas, 72 figuras.
Péptidos antihipertensivos derivados de proteínas lácteas: producción mediante levaduras no convencionales y mecanismos de acción
2015
En esta Tesis Doctoral se ha estudiado el potencial de levaduras no convencionales, pertenecientes a las especies Debaryomyces hansenii, Kluyveromyces lactis y Kluyveromyces marxianus, para generar hidrolizados y péptidos antihipertensivos provenientes de caseína (CN) o lactoferrina (LF). Además, se ha profundizado en el mecanismo de acción responsable del efecto antihipertensivo. Para ello, se han utilizado diferentes aproximaciones experimentales que incluyen ensayos in vitro para determinar los efectos inhibitorios sobre la actividad de la enzima conversora de angiotensina (ECA) y ensayos in vivo en ratas espóntaneamente hipertensas (SHRs) para estudiar los efectos sobre la presión arter…
Indicaciones de los inhibidores de PCSK9 en la práctica clínica. Recomendaciones de la Sociedad Española de Arteriosclerosis (SEA), 2019
2019
Resumen Un grupo de expertos convocado por la Sociedad Espanola de Arteriosclerosis (SEA) se ha encargado de actualizar el documento de la SEA sobre las indicaciones de los inhibidores de PCSK9 (iPCSK9) en la practica clinica publicadas en 2016. Esta actualizacion es necesaria porque en el periodo transcurrido hasta la actualidad se han publicado los resultados de los ensayos clinicos realizados a gran escala con iPCSK9 que demuestran que, ademas de su alta potencia para disminuir el colesterol aterogenico, disminuyen el riesgo de presentar episodios de enfermedad cardiovascular aterosclerotica en los pacientes con enfermedad tanto estable como reciente, y con un alto grado de seguridad. La…
Polymer-liposome nanoparticles obtained by the electrostatic bio-adsorption of natural polymers onto soybean lecithin liposomes
2012
This work is focused on the formulation of polymer-liposome nanoparticles based on the electrostatic bio-adsorption of natural polymers onto soybean lecithin liposomes, with potential as novel delivery system for macromolecules, such as proteins. The building up of the polymer-liposome nanoparticles was achieved through the alternating bio-adsorption of natural cationic (chitosan) and neutral (dextran) or anionic (dextran sulphate or alginate) polymer layers on a core composed by anionic nanosized soybean lecithin liposomes. The electrostatic bio-adsorption of natural polymers succeeded in building nanosized, spherical, monodisperse and stable polymer-liposome nanoparticles with cumulative …
Real‐world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B‐cell lymphoma
2021
Abstract Tisagenlecleucel (tisa‐cel) is a second‐generation autologous CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy approved for relapsed/refractory (R/R) large B‐cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa‐cel in the standard‐of‐care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa‐cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded accor…
CLOCK gene variation is associated with incidence of type‑2 diabetes and cardiovascular diseases in type‑2 diabetic subjects: dietary modulation in t…
2016
Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However, no longitudinal study has investigated the association between CLOCK…
Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor
2017
Prevenció; Atac d'angioedema; Inhibidor C1 Prevención; Ataque de angioedema; Inhibidor C1 Prevention; Angioedema attack; C1 inhibitor BACKGROUND: Hereditary angioedema is a disabling, potentially fatal condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use of CSL830, a nanofiltered C1 inhibitor preparation that is suitable for subcutaneous injection, resulted in functional levels of C1 inhibitor activity that would be expected to provide effective prophylaxis of attacks. METHODS: We conducted an international, prospective, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase 3 trial to evaluate the …
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
2020
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 d…
Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination
2019
[Background] High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors.