Search results for "PSA"
showing 10 items of 286 documents
Arginine-rich peptides are blockers of VR-1 channels with analgesic activity
2000
Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…
Are urban water bodies really cooling?
2020
Abstract Small urban water bodies, like ponds or canals, are often assumed to cool their surroundings during hot periods, when water bodies remain cooler than air during daytime. However, during the night they may be warmer. Sufficient fetch is required for thermal effects to reach a height of 1–2 m, relevant for humans. In the ‘Really cooling water bodies in cities’ (REALCOOL) project thermal effects of typical Dutch urban water bodies were explored, using ENVI-met 4.1.3. This model version enables users to specify intensity of turbulent mixing and light absorption of the water, offering improved water temperature simulations. Local thermal effects near individual water bodies were assesse…
Endotoxin inhibits gastric emptying in rats via a capsaicin-sensitive afferent pathway.
2001
The effects of endotoxin on gastric emptying of a solid nutrient meal and the neural mechanisms involved in such a response were investigated in conscious rats. The intraperitoneal (i.p.) administration of E. coli endotoxin (40 mug/kg) significantly reduced the 4-h rate of gastric emptying of a standard solid nutrient meal. Ablation of primary afferent neurons by systemic administration of high doses of capsaicin (20+30+50 mg/kg s.c.) to adult rats did not modify the rate of gastric emptying in control animals but prevented the delay in gastric transit induced by endotoxin. Local application of capsaicin to the vagus nerve rather than application of capsaicin to the celiac ganglion signific…
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon
2004
Background and aims: Protease activated receptors (PARs) have been postulated to play a role during intestinal inflammation. The presence and role played by PAR4 in gastrointestinal functions have not been fully clarified. The aims of this study were: (i) to examine expression of PAR4 in rat proximal colon; (ii) to determine the mechanical effects induced by PAR4 activation in longitudinal muscle; and (iii) to characterise the underlying mechanisms. Methods: PAR4 expression was determined by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Mechanical activity was recorded as changes in isometric tension. Results: A PCR product corresponding to the predicted…
SIA „RNP” uzņēmējdarbības iespējas.
2022
Bakalaura darba tēma SIA „RNP” uzņēmējdarbības pilnveides iespējas. Pētījuma mērķis, ir, noteikt problēmas SIA „RNP” uzņēmējdarbībā, lai izstrādātu priekšlikumus SIA „ RNP” uzņēmējdarbības pilnveidošanai. Pētot SIA „RNP” uzņēmējdarbību ir noteikts, ka SIA „RNP” ir vecās tehnoloģijas un iekārtas, kas rada klientiem būtiskos zaudējumus, nenopolarizē tēlu un reputāciju sociālajos tiklos, ir debitoru kavētie maksājumi, maksātspējas zemais līmenis 0,14;0,16;0,15;0,16 attiecībā pret optimālo rādītāja lielumu 0,5 un vairāk, kreditoru parāda pret pašu kapitālu liela attiecība 6,09;5,38;5,52;5,25 attiecībā pret optimālo rādītāja lielumu 0,7 un mazāk, kopējo izdevumu apmērs ir virs 99% attiecībā pret…
Sustainability of Pension Systems in the Baltic States
2016
Objective: The objective of the paper is to identify how the concept of sustainability is understood and ensured in the pension systems of Estonia, Latvia and Lithuania; and what implications it brings to the performance of pension schemes. Research Design & Methods: Analysis of various conceptual and methodological approaches to the notion of sustainability of pension systems. Comparative analysis of present pension legislation, as well as preceding stage of pension reforms, accompanied by a number of numerical models. Findings: The understanding of sustainability is limited by narrow ‘fiscal’ meaning in Latvia, compared to more a multifaceted concept that includes the principle of socia…
PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer
2020
68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study is to determine the optimum time for performing these PET/CT scans in a large cohort of patients by identifying the prostate-specific-antigen (PSA) and PSA kinetics thresholds for detecting and localizing recurrent PC. This retrospective analysis includes 581 patients with biochemical recurrence (BC) by definition. The performance of 68Ga-PSMA-11 PET/CT in relation to the PSA value at the scan time as well as PSA kinetics was assessed by the receiver-operating-characteristic-curve (ROC) generated by plottin…
Influence of capsaicin-sensitive afferent neurones on the acid secretory responses of the rat stomach in vivo.
1990
1. The influence of capsaicin-sensitive afferent neurones in modulating acid-secretory responses has been investigated in the continuously perfused stomach of the anaesthetized rat. 2. Ablation of primary afferent neurones, after systemic neonatal pretreatment with high doses of capsaicin, did not modify acid responses to direct stimuli of the oxyntic cell with histamine (5 mg kg-1), pentagastrin (20 micrograms kg-1) or carbachol (4 micrograms kg-1). 3. Acid responses to hypoglycaemia induced by insulin (0.3 iu kg-1) were not influenced by systemic capsaicin pretreatment or by acute coeliac ganglionectomy. Vagotomy abolished this secretory response. 4. The increase in acid output induced by…
Eicosapentaenoic acid modulates fatty acid metabolism and inflammation in Psammomys obesus.
2015
Abstract The desert gerbil, Psammomys obesus, is a unique polygenic animal model of metabolic syndrome (insulin resistance, obesity and type 2 diabetes), and these pathological conditions resemble to those in human beings. In this study, the animals were fed ad libitum either a natural diet (ND) which contained desertic halophile plants or a standard laboratory diet (STD) or a diet which contained eicosapentaenoic acid (EPA), hence, termed as EPA diet (EPAD). In EPAD, 50% of total lipid content was replaced by EPA oil. By employing real-time PCR, we assessed liver expression of key genes involved in fatty acid metabolism such as PPAR-α, SREBP-1c, LXR-α and CHREBP. We also studied the expres…
Topical capsaicin application and axon reflex vasodilatation of the tongue: Neurogenic involvement in burning mouth syndrome.
2006
The aim of this study was to evaluate the effects of topical capsaicin application on human lingual mucosa and to assess if neurogenic inflammation might have a role in the pathogenesis of lingual diseases. Thirty patients (16 males and 14 females; mean age: 41.46 +/- 11.8 years; range: 23-60) were examined in our laboratory. The neurogenic inflammation was experimentally induced in the lingual mucosa close to 1) the left margin of the tongue and 2) the right margin of the tongue after ipsilateral nerve trunk anesthesia. The characteristics of lingual microcirculation were observed using computerized videocapillaroscopic techniques. The vasodilatation was observed close to the left margin o…