Search results for "PSORIASIS"

2020

Background Psoriasis is a frequent chronic inflammatory cytokine‐mediated skin disease and was identified to be an independent risk factor for the occurrence of myocardial infarction (MI). However, data about the impact of psoriasis on mortality and other in‐hospital adverse events in the setting of MI are sparse and inconsistent. Methods and Results The nationwide German inpatient sample of the years 2005 to 2016 was used for statistical analysis. Hospitalized patients with MI were stratified for the presence of psoriasis and the impact of psoriasis on in‐hospital events was investigated. Overall, 3 307 703 patients with MI (37.6% females, 56.8% aged ≥70 years) were treated in Germany (20…

The GENDER ATTENTION Observational Study: Gender and Hormonal Status Differences in the Incidence of Adverse Events During Cyclosporine Treatment in …

2017

Introduction: Female sex has been shown to be a risk factor for the development of adverse drug reactions; however, this has not been studied for cyclosporine (CsA). The aim of this study was to investigate, in Italian dermatological practice, the influence of gender and menopause and related hormones on the incidence of adverse events (AEs) during CsA treatment in psoriatic patients. Methods: Multicenter, prospective, observational study conducted from May 2011 to June 2013. Patients with plaque psoriasis, undergoing a new CsA administration course, or about to start it, were enrolled in the outpatient clinics of Italian dermatological centers. During the 2–6 months of study duration, pati…

The Respiratory Burst and Psoriasis

1988

Psoriasis is a disease affecting about 1–2% of the population worldwide, similar to diabetes mellitus.1 It occurs somewhat more frequently in the white population than among Asians and Eskimos.1 The disease has two peaks of onset, an early one occurring around the age of 20 and a later one around 60.2 In early-onset psoriasis, 85% of patients exhibit the HLA Cw6 antigen; in the late-onset group, no such pattern of inheritance can be found.2

A Highly Decreased Binding of Cyclic Adenosine Monophosphate to Protein Kinase A in Erythrocyte Membranes is Specific for Active Psoriasis

2002

A cyclic adenosine monophosphate binding abnormality in psoriatic erythrocytes that could be corrected by retinoid treatment has been reported. It was tested whether this binding abnormality is specific for psoriasis and the effects of treatment were compared with etretinate, cyclosporine A, or anthralin on 2-(3)H-8-N(3)-cyclic adenosine monophosphate binding to the regulatory subunit of protein kinase A in erythrocyte membranes. One hundred and fifteen individuals were evaluated, including: (i) 34 healthy persons; (ii) 15 patients with nonatopic inflammatory skin diseases (eczema, erythroderma, tinea, Grover's disease, erysipelas, urticaria); (iii) eight with other dermatoses mediated by i…

Psoriasis y enfermedad arterial coronaria isquémica en la provincia de Castellón. Asociación con factores de riesgo

2015

La psoriasis es una enfermedad inflamatoria crónica mediada por el sistema inmune, que afecta a un 2-3% de la población adulta. En su fisiopatología intervienen entre otros, la activación de células presentadoras de antígeno, así como la expansión y activación de linfocitos T helper tipo 1, 17 y 22, que condiciona un aumento de diversas citoquinas como el FNT-α, IFN-γ, Il-17 e Il-22 a nivel cutáneo. Muchas de estas citoquinas inflamatorias, a través del sistema circulatorio, actúan a nivel sistémico induciendo un estado de inflamación crónica. La inflamación crónica Th1 y Th17 condiciona alteraciones metabólicas favorecedoras de la obesidad, diabetes, trombosis y arterioesclerosis. Así pues…

Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on t…

1996

Bone morphogenetic protein-6 (BMP-6) belongs to the family of TGF-beta-related growth factors. In the developing epidermis, expression of BMP-6 coincides with the onset of stratification. Expression persists perinatally but declines after day 6 postpartum, although it can still be detected in adult skin by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. We constitutively overexpressed BMP-6 in suprabasal layers of interfollicular epidermis in transgenic mice using a keratin 10 promoter. All mice expressing the transgene developed abnormalities in the skin, indicating an active transgene-derived factor. Depending on the pattern of transgene expression, the effects on proli…

Psoriasis vulgaris and genetic markers

1977

In a sample of n = 160 nonrelated male and female patients suffering from psoriasis Vulgaris, blood serum protein, and enzyme group typings have been carried out and compared with healthy controls from the same area (Rheinland-Pfalz). Marked statistically significant differences between patients and controls were found in none of the genetic blood polymorphisms considered here. However, combining previously published data from various authors with our own, significant associations between this skin disease and genetic polymorphisms such as MN, Gc, Gm (2), red cell acid phosphatase, and red cell phosphoglucomutase (PGM1) were seen. The possible reasons for these associations are discussed.

Knochenbefunde bei Psoriasis

1978

Unter 40 mit der Ganzkorperscintigraphie (Technetium-Diphosphonat) untersuchten Psoriatikern fanden sich bei 3 Patientinnen diffuse und umschriebene pathologisch gesteigerte Nuklidanreicherungen im Schadelskelet. Diese gelenkfernen Proliferationszeichen im Knochenbereich weisen ebenso wie der gegenuber dem Gelenkscan haufiger positive Knochenscan auf eine Fruhbeteiligung des knochernen Skelets bei Psoriasis hin.

Calidad de vida en los pacientes con psoriasis

2015

La psoriasis en una enfermedad sistémica crónica que conlleva exacerbaciones y remisiones a lo largo de la vida del paciente .Sólo se conocía la artropatía psoriásica como otra entidad nosológica asociada a la psoriasis cutánea. Sin embargo, en la actualidad se conoce ampliamente otras enfermedades relacionadas, patologías orgánicas, como es la enfermedad cardiovascular englobando en ella a todos sus factores de riesgo, así como patologías de la esfera psíquica que con frecuencia se manifiestan en estos pacientes. Estas patologías asociadas, ha cambiado de forma importante el abordaje que el dermatólogo debe hacer del paciente con psoriasis, llevando a cabo una visión integral desde el punt…

Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation.

2019

The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes triggers not only skin lesions but also systemic inflammation in mouse psoriasis models. Specific depletion of IκBζ in keratinocytes was sufficient to suppress the induction of imiquimod- or IL-36–mediated psoriasis. Moreover, IκBζ ablation in keratinocytes prevented the onset of psoriatic lesions and systemic inflammation in keratinocyte-specific IL-17A–transgenic mice. Mechanistically, this psoriasis protection was mediated by IκBζ deficiency in keratinocytes abrogating the induction of specific proinflammato…