Search results for "PSYCHOSIS"

Imaging Genetics of Hallucinations

2018

Structural and functional imaging of the brain language structures, regions, and circuits has revealed the association between brain anomalies and hallucinations in psychosis (see Chaps. 9, 10, and 11). Similarly genetic investigations have demonstrated the effect of gene variations on the severity of hallucination (see Chap. 7).

A first episode psychosis case-control genetic association study

2006

Background:GAP(genesandpsychosis) is a case-control studyof first episode psychosis conducted in London and Cambridge, which aims to identify genes conferring susceptibility to psychosis, and associated phenotypes including cognitive dysfunction and cerebral morphology. Methods:First episode psychosis cases have been recruited in South London and Maudsley NHS Trust and in Cambridge. A variety of demographic and clinical data have been collected. In a subset of these, neurocognitive assessments and MRIs have been performed. Samples have been taken for DNA, and in a subset for RNA and proteomic analysis. Genetic association analysis is being undertaken using a candidate gene approach. The gen…

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.

2009

Defects in genetic and developmental processes are thought to contribute susceptibility to autism and schizophrenia. Presumably, owing to etiological complexity identifying susceptibility genes and abnormalities in the development has been difficult. However, the importance of genes within chromosomal 8p region for neuropsychiatric disorders and cancer is well established. There are 484 annotated genes located on 8p; many are most likely oncogenes and tumor-suppressor genes. Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, S…

Predictors for Nursing Home Admission and Death among Community-Dwelling People 70 Years and Older Who Receive Domiciliary Care

2015

Original Research Article Aim: The aim of this study was to analyze which variables predicted nursing home admission (NHA) and death. Methods: 1,001 recipients of domiciliary care were assessed three times in a 3-year period. Through bivariate and multivariate Cox proportional hazards regression models, associations between a covariate and the outcomes were analyzed. Results: Participants with dementia had a higher risk of NHA (odds ratio 3.88, 95% confidence interval 2.92-5.16) compared to participants without dementia. The Neuropsychiatric Inventory sub-syndrome psychosis, poorer functional impairment and age were associated with NHA. Female sex, age, worse medical health and functional i…

A Pilot Study of Group Administered Metacognitive Training (MCT) for Schizophrenia Patients in a High-Security Forensic Setting: Subjective Training …

2015

Metacognitive group training (MCT) for psychosis has showed promising effects on positive symptoms of schizophrenia, even in forensic settings. Its effect on health-related quality of life (HRQOL) or patient perspective of it has not been studied before in violent inpatients. This pilot study investigated the patient perspective of the MCT, assessed the intervention’s effects on HRQOL compared with the control group, and compared the patients’ HRQOL with that of the general population. Twenty male violent inpatients with schizophrenia participated and were randomized to the eight-session MCT or to treatment as usual. The participants’ HRQOL was assessed at baseline, at posttreatment, and 3 …

What drives the higher incidence of psychosis in London compared to Palermo?

2016

Background: Incidence of psychosis seems to be lower in Italy than in other European countries (Tansella et al. 1991; Lasalvia et al. 2012, Tarricone et al. 2012); however there are no studies comparing the incidence of psychotic disorder in Northern and Southern Europe. Methods: Incidence and socio-demographic data on all psychotic patients presenting for the first time to the mental health services of Palermo were collected over a period of three years. Palermo incidence rates were compared to South London rates obtained from the AESOP study (Kirkbride et al 2006). South London rates were reanalyzed excluding people aged 16-17 years and substance related psychoses. Second generation migra…

Does clinical or cognitive insight predict outcome in psychosis? Findings from a longitudinal first episode cohort

2013

Abnormalities in serum concentrations of interleukin-2, interferon-alpha and interferon-gamma in schizophrenia not detected.

1992

The hypothesis of an immunological defect in schizophrenia has been supported by reports on abnormal production of interleukin-2 (IL-2) and interferons (IFNs) in schizophrenic patients. In the present study we determined the serum concentrations of IL-2, IFN-alpha and IFN-gamma in 10 first onset, neuroleptic-naive schizophrenics, in 6 pretreated patients who were drug free (1 week to 2 years) at the time of the investigation and in 15 matched healthy controls. No IFN-alpha was detected in schizophrenics' and in control sera. No differences were found in IL-2 and IFN-gamma levels between schizophrenics and controls. Thus the present study failed to support the hypothesis of an immunological …

Ruolo della working memory e dello stile di risposta Jumping To Conclusions in un campione di pazienti al first episode psychosis

2013

Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study

2018

Importance: Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. Objectives: To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. Design, Setting, and Participants: An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catch…