Search results for "PTC"
showing 10 items of 122 documents
Fine-Needle Aspiration (FNAB) Molecular Analysis for the Diagnosis of Papillary Thyroid Carcinoma through BRAFv600E mutation and RET/PTC rearrangement
2007
Objective: To evaluate BRAFV600E mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB’s usefulness in preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET=PTC1 and RET=PTC3 rearrangements obtained from ex vivo thyroid nodules. Design: Thyroid FNABs from 156 subjects with nodules and 49 corresponding surgical samples were examined for the presence of BRAF mutation by real-time allele-specific polymerase chain reaction, confirmed with the use of a laser pressure catapulting system. Samples were also examined for RET=PTC rearrangements. The results were compared with the cytological diagnosis and histopathol…
PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics
2015
INTRODUCTION: ameloblastoma is a slow growing, painless odontogenic swelling which can attain sizes that result in severe deformities of the craniofacial complex. It is the most commonly encountered odontogenic tumor in Nigeria. Surgical intervention is currently the method of treatment; however identification of altered molecular pathways may inform chemotherapeutic potential. The Protein Patched homolog 1 (PTCH-1) is overexpressed in ameloblastoma. Also, mutation in the MDM2 gene can reduce the tumor suppressor function of p53 and promote ameloblastoma growth. No study however has characterized the molecular profile of African cases of ameloblastoma with a view to developing chemotherapeu…
Wilms' tumor in patients with 9q22.3 microdeletion syndrome suggests a role for PTCH1 in nephroblastomas
2012
Nephroblastoma (Wilms' tumor; WT) is the most common renal tumor of childhood. To date, several genetic abnormalities predisposing to WT have been identified in rare overgrowth syndromes. Among them, abnormal methylation of the 11p15 region, GPC3 and DIS3L2 mutations, which are responsible for Beckwith-Wiedemann, Simpson-Golabi-Behmel and Perlman syndromes, respectively. However, the underlying cause of WT remains unknown in the majority of cases. We report three unrelated patients who presented with WT in addition to a constitutional 9q22.3 microdeletion and dysmorphic/overgrowth syndrome. The size of the deletions was variable (ie, from 1.7 to 8.9 Mb) but invariably encompassed the PTCH1 …
An Application of Hybrid Models in Credit Scoring
2000
The predictive capability of parametric and non-parametric models in solving problems related to financial classification has been widely proved in empirical research carried out in the financial field, particulary in problems like bond rating, bankruptcy prediction and credit scoring. However, recently, it has been shown that a combination of different models generally reduces the prediction error, so that the best alternative to consider may not be a specific model but a combination of them. In this paper, we study hybrid systems based on the aggregation of individual (parametric and nonparametric) models. Our hybrids are built by using both parametric and non parametric models as the sys…
La fallibilità delle società a partecipazione pubblica
2011
Lo studio ripercorre i nodi interpretativi legati alla suscettibilità delle società in mano pubblica esercenti attività d'impresa commerciale di essere soggette al fallimento in caso d'insolvenza. L'analisi critica degli orientamenti dottrinali e giurisprudenziali sul tema consente l'emersione di interrogativi rimasti irrisolti cui l'autrice tenta di dare una risposta attraverso una ricostruzione della disorganica normativa di riferimento.
Medidas durante el COVID-19 y Derecho mercantil (Parte II: Derecho concursal).
2020
The crisis generated by the COVID-19 pandemic has forced it to take multiple measures of different kinds to mitigate its effects during the Alarm State. These measures include those that have effects on various commercial law institutions, such as those relating to insolvency issues.
Vairogdziedzera mezglu analizēšana, izmantojot attēlu diagnostikas klasifikācijas un datu sistēmu (TIRADS), un salīdzinot ar Bethesda sistēmu
2017
Vairogdziedzera attēlu diagnostikas klasifikācijas un datu sistēma (Thyroid Imaging Reporting and Data System, TIRADS) ir klasifikācijas sistēma, kas iedala mezglu malignitātes riskus. Katra kategorija reprezentē vairogdziedzera mezgla malignitātes risku. Tā izveidota ar mērķi uzlabot reaģēšanu un izmaksu pārvaldību, samazinot vajadzību pēc ar tievu adatu aspirācijas biopsijas pacientiem, kuriem ir vairogdziedzera mezgli. TIRADS sistēma ir riska novērtēšanas sistēma vairogdziedzera audu bojājumu klasificēšanai. TIRADS novērtējums sniedz informāciju par vairogdziedzera struktūru, malignitātes risku un klasifikāciju. Bethesda sistēma vairogdziedzera citopatoloģiju novērtēšanai ir vairogdziedz…
Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway.
2014
Peripheral T-cell lymphomas not otherwise specified (PTCL/NOS) are very aggressive tumors characterized by consistent aberrant expression of platelet-derived growth factor receptor alpha (PDGFRA). In this study, we aimed to identify the determinants of PDGFRA activity in PTCL/NOS and to elucidate the biological consequences of its activation. We observed overexpression of the PDGFRA gene by gene expression profiling in most of the tested PTCLs and confirmed the expression of PDGFRA and phospho-PDGFRA using immunohistochemistry. The integrity of the PDFGRA locus was demonstrated using several different approaches, including massive parallel sequencing and Sanger sequencing. PDGF-AA was found…
Contagion in Bitcoin Networks
2019
12 pages, 6 figures. Paper accepted in 2nd Workshop on Blockchain and Smart Contract Technologies (BSCT 2019), workshop satellite of 22nd International Conference on Business Information Systems (BIS 2019); International audience; We construct the Google matrices of bitcoin transactions for all year quarters during the period of January 11, 2009 till April 10, 2013. During the last quarters the network size contains about 6 million users (nodes) with about 150 million transactions. From PageRank and CheiRank probabilities, analogous to trade import and export, we determine the dimensionless trade balance of each user and model the contagion propagation on the network assuming that a user go…