Search results for "PTH"
showing 10 items of 458 documents
Mid-region parathyroid hormone-related protein (PTHrP) binds chromatin of MDA-MB231 breast cancer cells and isolated oligonucleotides “in vitro”
2006
We have previously shown that PTHrP(38-94)-amide restrains growth and invasion "in vitro", causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated "in vivo". PTHrP(38-94)-amide contains the domain implicated in the nuclear import of PTHrP. Although the nucleus was identified as a destination for mid-region PTHrP, evidence for direct DNA-binding capability is lacking to date. Here, we examined the localization of PTHrP(38-94)-amide within MDA-MB231 cells and within metaphase spread preparations and characterized its DNA-binding properties, employing a combination of immunocytochemical, cytoge…
Parathyroid Hormone-Related Protein (PTHrP): A Key Regulator of Life/Death Decisions by Tumor Cells with Potential Clinical Applications
2010
Parathyroid hormone-related protein (PTHrP), classically regarded as the mediator of the humoral hypercalcemia of malignancy syndrome, is a polyhormone that undergoes proteolytic processing into smaller bioactive forms. These bioactive forms comprise an N-terminal- as well as midregion- and C-terminal peptides, which have been shown to regulate various biological events, such as survival, proliferation and differentiation, in diverse cell model systems, both normal and pathological. A number of experimental data have demonstrated that PTHrP is also able to modulate tumor-relevant phenotypic expressions, thereby playing a role in early and advanced tumorigenesis, and in the response to treat…
Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast cancer cells.
2007
It was previously reported that the midregion PTHrP domain (38-94)-amide restrains growth and invasion "in vitro", causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated "in vivo". In addition, we have demonstrated that midregion PTHrP is imported in the nucleoplasm of cultured MDA-MB231 cells, and that "in vitro" it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor-like DNA-binding ability. Here, we examined whether PTHrP (38-94)-amide was able to modulate the expression of genes e…
Remote sensing of vegetation dynamics in agro-ecosystems using smap vegetation optical depth and optical vegetation indices
2017
The ESA's SMOS and the NASA's SMAP missions, launched in 2009 and 2015, respectively, are the first two missions having on-board L-band microwave sensors, which are very sensitive to the water content in soils and vegetation. Focusing on the vegetation signal at L-band, we have implemented an inversion approach for SMAP that allows deriving vegetation optical depth (VOD, a microwave parameter related to biomass and plant water content) alongside soil moisture, without reliance on ancillary optical information on vegetation. This work aims at using this new observational data to monitor the phenology of crops in major global agro-ecosystems and enhance present agricultural monitoring and pre…
Sensitivity of L-band vegetation optical depth to carbon stocks in tropical forests: a comparison to higher frequencies and optical indices
2019
Supplementary data to this article can be found online at https://doi.org/10.1016/j.rse.2019.111303. Monitoring vegetation carbon in tropical regions is essential to the global carbon assessment and to evaluate the actions oriented to the reduction of forest degradation. Mainly, satellite optical vegetation indices and LiDAR data have been used to this purpose. These two techniques are limited by cloud cover and are sensitive only to the top of vegetation. In addition, the vegetation attenuation to the soil microwave emission, represented by the vegetation optical depth (VOD), has been applied for biomass estimation using frequencies ranging from 4 to 30¿GHz (C- to K-bands). Atmosphere is t…
Multi-Frequency Estimation of Canopy Penetration Depths from SMAP/AMSR2 Radiometer and IceSAT Lidar Data
2018
In this study, the $\tau-\omega$ model framework is used to derive extinction coefficient and canopy penetration depths from multi-frequency SMAP and AMSR2 retrievals of vegetation optical depth together with ICESat LiDAR vegetation heights. The vegetation extinction coefficient serves as an indicator of how strong absorption and scattering processes within the canopy attenuate microwaves at $\mathrm{L}$ and C-band. Through inversion of the extinction coefficient, the penetration depth into the canopy can be obtained, which is analyzed on local (Sahel, Illinois) and continental scale (Africa, parts of North America) as well as for a one year time series (04/2015-04/2016). First analyses of …
L-band vegetation optical depth seasonal metrics for crop yield assessment
2018
Attenuation of surface microwave emission due to the overlying vegetation is proportional to the density of the canopy and to its water content. The vegetation optical depth (VOD) parameter measures this attenuation. VOD could be a valuable source of information on agroecosystems, especially at lower frequencies for which greater portion of the vegetation canopy contributes to the observed brightness temperature. In the past, visible-infrared indices have been used to provide yield estimates based on measuring the photosynthetic activity from the surface canopy layer. These indices are affected by clouds and apply only in the presence of solar illumination. In this study we instead use the …
Estimation of vegetation loss coefficients and canopy penetration depths from SMAP radiometer and IceSAT lidar data
2017
In this study the framework of the τ — ω model is used to derive vegetation loss coefficients and canopy penetration depths from SMAP multi-temporal retrievals of vegetation optical depth, single scattering albedo and ICESat lidar vegetation heights. The vegetation loss coefficients serve as a global indicator of how strong absorption and scattering processes attenuate L-band microwave radiation. By inverting the vegetation loss coefficients, penetration depths into the canopy can be obtained, which are displayed for the global forest reservoirs. A simple penetration index is formed combining vegetation heights and penetration depth estimates. The distribution and level of this index reveal…
Calcifying phytoplankton standing stocks in the North Pacific from the R/V Kilo Moana cruise KM1712
2022
This dataset compiles the CaCO3 standing stocks of living coccolithophores (mg/m³), of detached coccoliths (mg/m³) and the integrated CaCO3 standing stocks of coccolithophores (mg/m²). The samples were collected in the North Pacific between Hawaii and the Gulf of Alaska during the R/V Kilo Moana cruise KM1712 in August 2017, with rosette Niskin bottles equiped with CTD (Sea-Bird SBE 9) at different depths throughout the photic zone including the deep chlorophyll maximum. To estimate the CaCO3 contribution by coccolithophore assemblages in each sample, we carried out the transformation of coccospheres in number of coccoliths, following the estimates by Yang and Wei (2003), and then we adopte…
Integrated annual calcium carbonate production of planktic calcifiers in the North Pacific from the R/V Kilo Moana cruise KM1712
2022
This dataset compiles the estimates of annual CaCO3 production, including the upper and lower limits of the estimates, for the 4 planktic calcifying groups considered in the study, the pteropods (mg/m²/yr), the heteropods (mg/m²/yr), the foraminifers (mg/m²/yr) and the coccolithophores (mg/m²/yr). The estimates derived from the living standing stocks of these 4 groups of organisms collected in the North Pacific between Hawaii and the Gulf of Alaska during the R/V Kilo Moana cruise KM1712 in August 2017. R code was used to calculate the integrated annual CaCO3 production for the different organisms, including the upper and lower limits (Gray, 2022).