Search results for "PTO"
showing 10 items of 28599 documents
Predicción del éxito y el rendimiento académico en estudiantes dominicanos de tercero de secundaria: Un modelo procesual de variables contextuales y …
2019
El estudio “Predicción del éxito y el rendimiento académico en estudiantes dominicanos de tercero de secundaria: Un modelo procesual de variables contextuales y personales”, se ha realizado con una muestra representativa de 1,712 estudiantes de los Distritos Educativos 03-04 y 11-01. Los objetivos del estudio son: a) determinar las características psicométricas de los cuestionarios del estudio; b) analizar cómo afectan al éxito y al rendimiento académico distintas variables contextuales: apoyo padres, compañeros y docentes, zona de residencia, sector educativo, calidad del centro, nivel estudio de padres, pertenencia a grupos juveniles, práctica deportiva, sexo y edad; c) analizar cómo afec…
α2β1-integriinin ja stimuloidun epidermaalisen kasvutekijä-reseptorin reittien yhteydet
2011
Integriinien ja kasvutekijäreseptorien kulku solussa yhdistyy monimutkaisen vuorovaikutusten verkoston kautta. Ympäristön olosuhteista riippuvaisesti integriinit ja kasvutekijäreseptorit kantavat pääasiallisen vastuun solun selviytymisestä, kasvusta, erilaistumisesta, vaeltamisesta ja lisääntymisestä. Integriinit kiinnittävät solut alustaansa ja kasvutekijäreseptorit voivat vastata liukoisten ligandien haasteisiin. α2β1-integriinit reagoivat ligandeihinsa, joita voivat olla matriksimolekyylit, virukset ja keinotekoisesti myös vasta-aineet. Integriinien klusterointi viruksella tai vasta-aineilla aiheuttaa integriinin internalisaation endosomeihin, kun taas sitoutuminen matriksimolekyyleihin …
Selection on two behavioral genes : fitness effects of receptor genes for arginine vasopressin 1a and oxytocin in the bank vole Myodes glareolus
2017
Most variation in behavior is regulated by genes; nevertheless the mechanisms behind maintenance of genetic diversity at behavioral loci have remained mainly elusive in natural populations. I studied in my thesis selection mechanisms of two genes associated with socio-sexual behavior, arginine vasopressin receptor 1a (Avpr1) and oxytocin receptor (Oxtr) in bank vole (Myodes glareolus). Expression of Avpr1a and Oxtr in specific regions of the brain regulates diverse social and reproductive behaviors such as parental care, aggression, sexual behavior, social recognition as well as pair and parent- offspring bonding in mammals. In addition, there is a link between the length of a regulatory re…
An in vitro model to study the adipose tissue toll-like receptor -mediated effects of gut microbiota on non-alcoholic fatty liver disease development
2017
Alkoholista riippumaton rasvamaksa (NAFLD) on maailman yleisin maksasairaus ja saattaa johtaa kirroosin tai maksasyövän kehittymiseen. Viimeaikaisissa tutkimuksissa suolistosta peräisin olevin bakteerimolekyylien, kuten flagelliinin (FLG) ja lipopolysakkaridien (LPS), rooli rasvamaksan kehittymisessä on tunnistettu. Nämä molekyylit saattavat vaikuttaa maksaan välillisesti rasvakudoksen kautta toll-like reseptorien (TLR) signaalireittejä aktivoiden. Tässä tutkimuksessa selvitettiin FLG:n ja LPS:n rasvasoluvälitteisiä vaikutuksia HepG2-hepatoomasoluihin. Hypoteesina oli, että FLG ja LPS lisäisivät HepG2 soluissa rasvan kerääntymistä, insuliiniresistenssiä ja tulehdusta, joita mitattiin kvanti…
Specific serum IgE to Ascaris lunbricoides and onset of respiratory symptoms in Blangladesh immigrants
2007
Ambito operativo dell'art. 1229 c.c. e responsabilità ex recepto
2012
Una riflessione sull’antica questione della responsabilità della banca per il servizio di cassette di sicurezza può ben rappresentare l’occasione per un ripensamento delle ricostruzioni più accreditate circa i rapporti tra autonomia privata e disciplina sulla responsabilità contrattuale. L’idea sottesa a questo scritto e` infatti che l’ambito operativo dell’art. 1229 c.c., disposizione normativa che consente una limitazione convenzionale della diligenza dovuta nell’adempimento, non si estenda a tutte le ipotesi di responsabilità contrattuale, risultando incompatibile con le ipotesi di responsabilità ex recepito, in cui sussiste un’endemica sovrapposizione tra il piano dell’inadempimento e q…
Retinal Vascular Assessment in Psoriasis: A Multicenter Study
2021
PurposeTo investigate the vascular status of the macula in psoriasis patients without history of ocular inflammation by Optical Coherence Tomography Angiography (OCTA).MethodsThis prospective cross-sectional multicenter study included 55 psoriasis patients and 55 control healthy subjects. A complete eye examination and 6 mm × 6 mm OCTA imaging were performed. Retinal vascular status was evaluated by analyzing vascular density (VD) of superficial vascular plexus (superficial wVD) and deep vascular plexuses (deep wVD) in a 6 mm × 6 mm area and in foveal (superficial fVD and deep fVD) and parafoveal sectors (superficial pVD and deep pVD). In addition, foveal thickness (FT) and foveal avascular…
Deep sequencing of the human retinae reveals the expression of odorant receptors
2017
Several studies have demonstrated that the expression of odorant receptors (ORs) occurs in various tissues. These findings have served as a basis for functional studies that demonstrate the potential of ORs as drug targets for a clinical application. To the best of our knowledge, this report describes the first evaluation of the mRNA expression of ORs and the localization of OR proteins in the human retina that set a stage for subsequent functional analyses. RNA-Sequencing datasets of three individual neural retinae were generated using Next-generation sequencing and were compared to previously published but reanalyzed datasets of the peripheral and the macular human retina and to reference…
Serum omega-3 fatty acids are not associated with age-related macular degeneration
2012
Revue non indexée dans le JCR.; International audience; Evaluation of: Kabasawa S, Mori K, Horie-Inoue K et al. Associations of cigarette smoking but. not serum fatty acids with age-related macular degeneration in a Japanese population. Ophthalmology 118(6), 1082–1088 (2011). Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly. in developed countries. Risk factors for AMD are classified into endogenous nonmodifiable. factors, including genetics and environmental factors such as smoking and dietary habits. Both. epidemiological and experimental studies suggest that dietary omega-3 long-chain fatty acids. would participate to prevent from the develo…
Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?
2021
Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cyt…