Search results for "PTO"

Caracterización espacio frecuencial y funcional de los fenómenos de prevalencia ocular

2018

Determinar con exactitud la dominancia ocular es importante en aquellos casos en los que es necesario inducir monovisión. Esto sucede en determinadas técnicas de cirugía refractiva, intervenciones de cataratas y adaptaciones de lentes de contacto. Especialmente críticas son las intervenciones quirúrgicas donde el proceso es irreversible y las inadaptaciones a la situación creada, si la dominancia ocular ha sido incorrectamente determinada, pueden crear importantes problemas de astenopia visual de difícil solución debido a la reducida plasticidad del sistema visual de los sujetos, por lo general adultos. Poder disponer de un sistema que pueda proporcionar de forma sencilla y fiable toda la i…

Expiration of Time Limits and the Ius Appellationis

2022

The rotal decree under comment offers the cue to address the delicate topic of the appeal and the peremptory time limits for its presentation, especially in light of the recent reform of the canonical matrimonial process promulgated by Pope Francis.On the basis of the new structure of the process of matrimonial nullity appears, in fact, evident the legislative disfavor, towards the appeal, seen as a potentially dangerous tool for the salus animarum of the faithful for the risk of procedural lengths connected to it, so as to provide for a prior examination of admissibility in order to avoid that they were made for the purpose of mere dilatory, that is, for the sole purpose of lengthening the…

Percepcja kryptowalut przez młodych uczestników rynku finansowego na przykładzie Polski i Niemiec

2022

W niniejszym artykule przedstawiono wyniki badań empirycznych dotyczących percepcji kryptowalut wśród młodych uczestników rynku finansowego. Badania zostały przeprowadzone w 2019 r., przed wybuchem pandemii COVID-19, niemal równocześnie w dwóch krajach: w Polsce i w Niemczech. Celem tych badań było uchwycenie różnic w sposobie postrzegania walut krajowych, światowych walut rezerwowych oraz kryptowalut, a także różnic w poziomie zaufania do dotychczasowego systemu finansowego na świecie. Wyniki badań pokazały, że istnieją znaczne różnice w percepcji, wynikające z wielu czynników, m.in. poziomu rozwoju gospodarki, innowacyjności rynków finansowych, historycznych uwarunkowań i będącej ich poch…

Kriptovalūtu sektora rīcībpolitikas analīze Eiropas Savienības un Latvijas kontekstā

2019

Bakalaura darba tēma ir “Kriptovalūtu sektora rīcībpolitikas analīze Eiropas Savienības un Latvijas kontekstā”. Darba būtība ir analizēt sektoru, kura attīstība var būtiski ietekmēt valsts tautsaimniecību. Darba mērķis ir izvērtēt kriptovalūtu sektora rīcībpolitiku un tās attīstību Latvijā, kā arī apzināt riskus, Latvijā ieviešot jaunu rīcībpolitiku šajā sektorā. Darba gaitā tiek identificēta galvenā sektorā pastāvošā problēma - anonimitāte, tiek identificēti riski, ka arī aplūkots kriptovalūtu šā brīža statuss Eiropas Savienībā un atsevišķās tās dalībvalstīs – Vācijā, Igaunijā, Maltā un Francijā. Teorētiskajā daļā tiek aplūkota rīcībpolitikas teorija, kā arī kritēriji veiksmīgas rīcībpolit…

Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor

2020

Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …

Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study

2016

Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…

Beta-decay studies for applied and basic nuclear physics

2020

In this review we will present the results of recent beta-decay studies using the total absorption technique that cover topics of interest for applications, nuclear structure and astrophysics. The decays studied were selected primarily because they have a large impact on the prediction of a) the decay heat in reactors, important for the safety of present and future reactors and b) the reactor electron antineutrino spectrum, of interest for particle/nuclear physics and reactor monitoring. For these studies the total absorption technique was chosen, since it is the only method that allows one to obtain beta decay probabilities free from a systematic error called the Pandemonium effect. The me…

Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging

2011

Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

2020

Tenapanor for the treatment of irritable bowel syndrome with constipation.

2020

Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …