Search results for "PTO"

Theoretical predictions of wimp-nucleus and neutrino-nucleus scattering in context of dark matter direct detection

2018

The nature of dark matter is at present an open question. Assuming the main component of dark matter consists of weakly interacting massive particles (WIMPs), directly detecting such particle via a scattering process with an atomic nucleus would be a strong probe into properties of dark matter. So far direct detection experiments have not provided a conclusive signal of dark matter. Traditionally the experiments aim to detect a coherent, spin- independent, elastic scattering signal which is enhanced by the square of the nuclear mass number. If the coherent channel is for some reason suppressed for WIMP-nucleus interactions, then spin-dependent interactions become important. In this thesis w…

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

Music, vibrotactile mediation and bodily sensations in anorexia nervosa : "It's like I can really feel my heart beating"

2020

This article presents the theoretical, scientific, and methodological foundations for the design and implementation of an innovative technological and clinical platform that combined sound, music, and vibrotactile mediation used in a therapeutic setting by adolescents suffering from anorexia nervosa. In 2019, we carried out a pilot experiment with a group of 8 adolescent patients hospitalized in the Eating Disorders Unit of the Department of Adolescent and Young Adult Psychiatry of the Institut Mutualiste Montsouris in Paris. Within this clinical framework, we aimed to create conditions suitable for patients to reinvest in their “disaffected” bodily zones and internal experiences through re…

Laser fluence, repetition rate and pulse duration effects on paint ablation

2006

Abstract The efficiency (mm3/(J pulse)) of laser ablation of paint was investigated with nanosecond pulsed Nd:YAG lasers (λ = 532 nm) as a function of the following laser beam parameters: pulse repetition rate (1–10,000 Hz), laser fluence (0.1–5 J/cm2) and pulse duration (5 ns and 100 ns). In our study, the best ablation efficiency (η ≅ 0.3 mm3/J) was obtained with the highest repetition rate (10 kHz) at the fluence F = 1.5 J/cm2. This ablation efficiency can be associated with heat accumulation at high repetition rate, which leads to the ablation threshold decrease. Despite the low thermal diffusivity and the low optical absorption of the paint (thermal confinement regime), the ablation th…

Applications and non-idealities of submicron Al–AlOx–Nb tunnel junctions

2016

We have developed a technique to fabricate sub-micron, 0.6µm×0.6µm Al-AlOx-Nb tunnel junctions using a standard e-beam resist, angle evaporation and double oxidation of the tunneling barrier, resulting in high quality niobium, as determined by the the high measured values of the critical temperature TC ∼ 7.5 K and the gap ∆ ∼ 1.3 meV. The devices show great promise for local nanoscale thermometry in the temperature range 1 - 7.5 K. Electrical characterization of the junctions was performed at sub-Kelvin temperatures both with and without an external magnetic field, which was used to suppress superconductivity in Al and thus bring the junction into a normal-metal-insulator-superconductor (NI…

QCD NLO with Powheg matching and top threshold matching in WHIZARD

2016

We present the status of the automation of NLO processes within the event generator WHIZARD. The program provides an automated FKS subtraction and phase space integration over the FKS regions, while the (QCD) NLO matrix element is accessed via the Binoth Les Houches Interface from an externally linked one-loop program. Massless and massive test cases and validation are shown for several e+e- processes. Furthermore, we discuss work in progress and future plans. The second part covers the matching of the NRQCD prediction with NLL threshold resummation to the NLO continuum top pair production at lepton colliders. Both the S-wave and P-wave production of the top pair are taken into account in t…

"Bitcoin" kā alternatīvā valūta

2018

Mūsdienās virtuālās valūtas, it īpaši “Bitcoin”, kļūst par aizvien aktuālāko tematu, tāpēc autore izvēlējās to pētīt. Bakalaura darbā “”Bitcoin” kā alternatīvā valūta” tika pētīta virtuālā valūta: tās raksturojums, veidi, un virtuālās valūtas “Bitcoin” iespējas kļūt par alternatīvo valūtu. Darba mērķis ir izanalizēt “Bitcoin” valūtu, tās priekšrocības un trūkumus kā alternatīvas valūtas. Lai to sasniegtu, tika izvirzīti vairāki uzdevumi: •izpētīt dažādus informācijas avotus par virtuālo valūtu un konkrēti par “Bitcoin” valūtu; •raksturot virtuālās valūtas veidus; •izanalizēt tiesisko regulējumu virtuālo valūtu jomā; •izanalizēt “Bitcoin” norēķinu sistēmu; •izanalizēt pieejamos statistikas d…

Identifying Critical Determinants of ‘Digital Customer Services’ Usage – An Exploratory Study

2019

Digital technology has reinvented retail business as well as commerce. This study aims to examine consumers’ perception and usage of digital customer services (DCS) and investigate three significant post-adoption and marketing consequences: simplicity, awareness, and usefulness. Using a purposeful sampling technique, 10 semi-structured, in-depth interviews were conducted with banking customers in Finland in January 2019. The research findings suggest that simplicity regarding DCS occupies a key position in their prolonged use, while awareness and usability are also important. This study offers some valuable theoretical and managerial implications and suggests an agenda for future research. …

Effect of ligand-binding on protein function

2014

Bending Work Time: Curvilinear Relationship Between Working Time Dimensions and Psychological and Somatic Symptoms.

2020

Objectives Study examines the curvilinear associations of working time dimensions (working hours, time pressure, work schedules, and control of work time and pace) on psychological and somatic symptoms. Methods Representative Finnish Quality-of-Work-Life Surveys conducted in 2003, 2008 and 2013 were restricted to those (N=11,165) regularly working over 10h/week with more than one-year tenure in their job. Generalised additive models were utilised in analysis. Results Working hours had U-shaped relationships with psychosomatic symptoms, while time pressure had a threshold effect. Work pace control had linear effect. The effects of work time control and work schedules were insignificant. Ther…