Search results for "PTO"
showing 10 items of 28599 documents
The Developmental Transcriptome for Lytechinus variegatus Exhibits Temporally Punctuated Gene Expression Changes
2019
AbstractEmbryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly valuable model organism for understanding developmental specification, morphogenesis, and evolution. As a non-chordate deuterostome, the sea urchin occupies an important evolutionary niche between protostomes and vertebrates.Lytechinus variegatus(Lv) is an Atlantic species that has been well studied, and which has provided important insights into signal transduction, patterning, and morphogenetic changes during embryonic and larval development. The Pacific specie…
Lexical Substitution and Paraphasia in Advanced Dementia of the Alzheimer Type
2017
Abstract The paper presents the case study of lexical selection in Alzheimer-type dementia. Lexical substitutions in poem recitation and conversations of a Russian speaker, who suffered Alzheimer-type dementia, were analyzed on the background of the lexical retrieval and slip-of-the-tongue phenomena. The classification of the substitutions is worked out on the basis of the links between a target word and its substitutions. The current context plays an essential role as natural priming for a substitution in a poem recitation. Some words have predisposition to be lost; the units belong to the figurative language or to the category of infrequent lexemes. In conversation, the patient masked fai…
Proapoptotic effects of oligodendroglioma cells on primary brain cells in culture.
2009
The Broker in Pornography and Violence: Lou Reed in Lulu’s World
2020
The article analyses the literary and cultural layers of Lulu, the album published by Lou Reed in collaboration with Metallica, based on Frank Wedekind’s two modernist dramas: Earth Spirit (1895) and Pandora’s Box (1904). In Reed’s reinterpretation, the two plays become his means through which he enters the area of disturbing perversion and graphic pornography. Consequently, Reeds seems to follow Susan Sontag’s diagnosis according to which the goal of pornographic literature is to disorient and to disturb mental balance. In the case of Lulu, it demonstrates Reed’s strategies of crossing the borders between what is commonly accepted and what is rejected because of its non-normative quality. …
Consecuencias psicológicas del maltrato en menores expuestos a violencia de género : regulación emocional, funciones ejecutivas y autoconcepto
2013
INTRODUCCIÓN Y MARCO TEÓRICO: Cada vez existe mayor evidencia de las repercusiones que comporta la exposición del maltrato en el desarrollo y salud mental de los menores, hijos e hijas de mujeres maltratadas. Es por ello que en los últimos tiempos está aumentando el interés social sobre las consecuencias psicológicas que supone estar expuesto al maltrato. Sin embargo, todavía hay pocos estudios que se dirijan a evaluar y corroborar dichos efectos en esta población. Según el modelo del Trauma Complejo, algunas situaciones traumáticas podrían producir un efecto mayor y más prolongado en la persona que lo sufre en función de algunas variables. Así, las experiencias traumáticas que se dan en la…
Apoptosis in human unfertilized oocytes after intracytoplasmic sperm injection
2005
Objective To investigate the presence of programmed cell death in unfertilized oocytes after intracytoplasmic sperm injection (ICSI), assuming that previous apoptotic events could be correlated with the fertilization failure. Design Comparison of the rate of DNA fragmentation in human oocytes at different stages of maturation soon after pick-up (control) and in unfertilized oocytes after ICSI treatment. Setting In vitro fertilization (IVF) laboratory with extensive ICSI experience. Patient(s) Sixty-three patients undergoing assisted fertilization by ICSI. Intervention(s) Terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) assay and anticaspase-3 cleaved…
Measurement of dielectron production in central Pb-Pb collisions at √sNN = 2.76 TeV
2019
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. The first measurement of dielectron (e + e −) production in central (0 – 10 %) Pb – Pb collisions at √sNN=2.76TeV at the LHC is presented. The dielectron invariant-mass spectrum is compared to the expected contributions from hadron decays in the invariant-mass range 0 < mee < 3.5 GeV / c2. The ratio of data and the cocktail of hadronic contributions without vacuum ρ0 is measured in the invariant-mass range 0.15 < mee < 0.7 GeV / c2, w…
Kriptovalūtas saistība ar noziedzīgas mantas legalizāciju
2022
Bakalaura darba tēma “Kriptovalūtas saistība ar noziedzīgas mantas legalizāciju” sniedz ieskatu par kriptovalūtas tiesiskā regulējuma trūkumu Latvijā. Darbā tiek aplūkota kriptovalūtas jēdziena attīstība normatīvajos tiesību aktos un sastāva pazīmes noziedzīgi iegūtu līdzekļu legalizēšanā, izmantojot kriptovalūtu. Problēma ir tiesiskā regulējuma trūkumā, lai efektīvi ierobežotu kriptovalūtas izmantošanu noziedzīgi iegūtu līdzekļu legalizēšanā un šo noziegumu atklāšanā. Darba ietvaros tika analizēta kriptovalūtas jēdziena atbilstība tās pazīmēm un pētīts, vai likuma subjekti, ievērojot Latvijas un Eiropas Savienības noziedzīgi iegūtu līdzekļu legalizēšanas novēršanas tiesiskā regulējuma pras…
Pathogenic mechanisms of how human parvovirus breaks self-tolerance
2017
It is known that viral infections can cause acute, chronic, and autoimmune diseases (ADs). However, the mechanism of how a persistent viral infection contributes to ADs remains still unclear. In this thesis, pathological and immunological aspects of how common viruses can initiate autoimmunity were investigated, and human parvovirus B19 (B19V) was employed as a model virus. B19V non-structural protein 1 (NS1), a superfamily 3 (SF3) helicase, initiated DNA damage resulting in cellular apoptosis. The apoptotic bodies (ApoBods) induced by B19V NS1 were purified and characterized. These ApoBods contained viral NS1 proteins with modified autoimmune-associated self-antigens, e.g. DNA, Smith, Apol…
Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms i…
2014
Single nucleotide polymorphisms (SNPs) in genes involved in the activation or regulation of innate and adaptive immune responses may modulate the susceptibility to and the natural history of certain chronic viral infections. The current study aimed to investigate whether donor and recipient SNPs in the chemokine receptor 5 (rs1800023), monocyte chemoattractant protein 1 (rs13900), interleukin-10 (rs1878672), and Toll-like receptor 9 (rs352140) genes would exert any influence on the rate of incidence and features of CMV DNAemia in the allogeneic stem cell transplantation setting. This was a retrospective observational multicenter study. The cohort consisted of 102 non-consecutive allogeneic …