Search results for "PULMONARY"

Observation of ventilation-induced Spo(2) oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

2010

High arterial partial oxygen pressure (Pao(2)) oscillations within the respiratory cycle were described recently in experimental acute lung injury. This phenomenon has been related to cyclic recruitment of atelectasis and varying pulmonary shunt fractions. Noninvasive detection of Spo(2) (oxygen saturation measured by pulse oximetry) as an indicator of cyclic collapse of atelectasis, instead of recording Pao(2) oscillations, could be of clinical interest in critical care. Spo(2) oscillations were recorded continuously in three different cases of lung damage to demonstrate the technical feasibility of this approach. To deduce Pao(2) from Spo(2), a mathematical model of the hemoglobin dissoci…

The murine bronchopulmonary microcirculation in hapten-induced inflammation

2006

ObjectiveThe clinical observation of central bronchial artery hypertrophy in chronic lung inflammation suggests the possibility that the bronchial circulation may also participate in adaptive responses in peripheral lung inflammation.MethodsTo investigate the potential role of the bronchial microcirculation in peripheral lung inflammation, we developed a murine model of lung inflammation using the intratracheal instillation of the peptide-hapten trinitrophenol in presensitized mice.ResultsClinical parameters indicated a peak inflammatory response at 96 hours. Similarly, gross and microscopic evidence of inflammation was observed 96 hours after antigen instillation. Using a forced oscillatio…

Serum Surfactant Protein D as a Marker of Asthma Severity

2016

Sex-specific and age-related seasonal variations regarding incidence and in-hospital mortality of pulmonary embolism in Germany

2020

Background Studies have reported seasonal variations regarding the incidence and the short-term mortality of pulmonary embolism (PE). The aim of this study was to identify sex-specific and age-related differences in seasonal patterns regarding hospitalisations and mortality of PE patients. Methods We analysed the impact of seasons on incidence and in-hospital mortality of male and female hospitalised PE patients in Germany (2005–2015) based on the German nationwide inpatient sample. Results The German nationwide inpatient sample comprised 885 806 hospitalisations due to PE (2005–2015). Seasonal variations of both incidence (p=0.021) and in-hospital mortality (p<0.001) were of significant ma…

Mid-regional pro-atrial natriuretic peptide and copeptin as indicators of disease severity and therapy response in CTEPH

2020

Background Chronic thromboembolic pulmonary hypertension (CTEPH) leads to right heart failure. Pulmonary endarterectomy (PEA) or balloon pulmonary angioplasty (BPA) restore pulmonary haemodynamics and allow cardiac recovery. This study examined the relationship of copeptin and mid-regional pro-atrial natriuretic peptide (MR-proANP) levels to disease severity and therapy response. Methods This observational cohort study included 125 patients (55 PEA/70 BPA) who underwent treatment and completed a 6-/12-month follow-up. Biomarkers, measured at baseline, prior to every BPA and at follow-up, were compared to 1) severe disease at baseline (right atrial pressure (RAP) ≥8 mmHg and cardiac index ≤2…

A New Technical Approach For Retrograde Administration of Cardioplegic Solutions

1989

Myocardial protection via the coronary sinus is now currently used by several groups. Although it has generally provided satisfactory results, some of its problems are still not completely resolved. We present a new technique of cardioplegia delivery through the coronary sinus with a Pezzer catheter inserted into it and secured in place by a purse string suture. We believe that this method is safer and more reliable than others.

Why small particle fixed dose triple therapy? An excursus from COPD pathology to pharmacological treatment evolution

2022

Although bronchodilators are the cornerstone in chronic obstructive pulmonary disease (COPD) therapy, the treatment with a single-agent bronchodilator may not provide adequate symptoms control in COPD. The combination of drugs with different mechanisms of action may be more effective in inducing bronchodilation and preventing exacerbations, with a lower risk of side-effects in comparison with the increase of the dose of a single molecule. Several studies comparing the triple therapy with the association of long-acting ß2 agonist (LABA)/inhaled corticosteroid (ICS) or long-acting muscarinic antagonist (LAMA)/LABA reported improvement of lung function and quality of life. A significant reduc…

OA12.05 Imaging-Guided Target Volume Reduction in Radiotherapy of Lung Cancer: The Prospective Randomized Multinational PET-Plan Trial

2019

253. La pandemia y el Geoforo Iberoamericano en 2020

2021

La pandemia de la COVID-19, que nos afecta desde los primeros meses de 2020, ha modificado nuestras costumbres y rutinas. Y también la manera de relacionarnos en los medios escolares y universitarios. Desde el Geoforo Iberoamericano sobre Educación, Geografía y Sociedad hemos considerado que se abría una oportunidad para re-pensar los problemas sociales y ambientales que condicionan nuestra cotidianidad. Desde el estudio de situaciones particulares hemos querido definir los problemas intelectuales que sean susceptibles de ser trabajados en las aulas. Esta consideración es fruto de la evolución que venimos manteniendo desde 2008 y que se valoró en el Coloquio de 2019 en Bogotá, del cual tamb…

Aportación europea a la especialidad de cirugía torácica general. II parte: contribución británica

2012

Resumen Es a principios de la Primera Guerra Mundial cuando se multiplicaron las tecnicas quirurgicas en el Reino Unido. Los drenajes, el tratamiento de las heridas abiertas y las complicaciones como los empiemas eran el inicio de nuevas tecnicas, innovadoras y resolutivas en estos casos. En esos anos, muchos de los cirujanos britanicos abandonaron el pais. Hemos de resenar que se crearon nuevos hospitales, como el Brompton en Londres. Fue fundado por la Reina Victoria como “hospital para enfermedades del torax”. Hemos de mencionar al Dr. Barret que, procedente de Adelaida (Australia), forma parte del equipo quirurgico de este hospital. En 1971, MacArthur consiguio una supervivencia de dos …