Search results for "PULMONARY"

Physicochemical investigation of acrylamide solubilization in sodium bis(2-ethylhexyl)sulfosuccinate and lecithin reversed micelles.

2003

The state of acrylamide confined within dry sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and lecithin reversed micelles dispersed in CCl4 has been investigated by FTIR and H-1 NMR spectroscopy. Measurements have been performed at 25 degreesC as a function of the acrylamide-to-surfactant molar ratio (R) at a fixed surfactant concentration (0.1 mol kg(-1)). The analysis of experimental data, corroborated by the results of SAXS measurements, is consistent with the hypothesis that acrylamide is quite uniformly distributed among reversed micelles mainly located in proximity to the surfactant head-group region and that its presence induces significant unidimensional growth of micellar aggregates.…

The difference in risk of chronic pulmonary disease morbidity and mortality between elite athletes and ordinary men in Finland

2020

Introduction: The impact of a history of competitive sports on later smoking behavior and occurrence of chronic pulmonary diseases is poorly known. We investigated how a history of elite level sports predicted later pulmonary disease morbidity and mortality. Methods: Chronic pulmonary disease incidence were assessed from national hospital and cause-of-death registers from 1970 to 2015 among Finnish male former elite athletes (n=2078) and matched controls (n=1453) alive in 1970 (mean age 45.0 years). Hazard ratios (HRs) were calculated by Cox proportional hazards model. In 1985, cohort members reported on their smoking habits, engagement in physical activity/sports and physician-diagnosed ch…

Structure and optical properties of a monolayer single crystal of a cyanine dye

1992

Abstract Molecularly thin single crystals of a cyanine dye prepared by adsorption at a charged surfactant monolayer are studied by polarized optical spectroscopy and electron diffraction. Both techniques independently show a herringbone arrangement of the dye with the long axes of translationally inequivalent molecules forming an angle of 80°. The dye arranges in a primitive rectangular unit cell (a=21.2 A, b=6.14 A) adjacent to an epitaxially related hexagonal cell of the aliphatic tails of the surfactant.

Coexistence of frailty syndrome and the level of health behaviors in elderly patients with chronic obstructive pulmonary disease

2023

Wprowadzenie: Przyspieszenie tempa starzenia się populacji, związane z tym ryzyko występowania zespołu słabości oraz wzrost liczby osób żyjących z przewlekłą obturacyjną chorobą płuc (POChP) powodują, że przyszłe kierunki polityki zdrowotnej powinny się skupiać na działaniach z zakresu promocji zdrowia, potęgowaniu zachowań prozdrowotnych, utrzymaniu lub poprawie sprawności funkcjonalnej starzejących się ludzi. Cel pracy: Analiza współwystępowania zespołu kruchości oraz nasilenia zachowań zdrowotnych u pacjentów w wieku podeszłym z POChP, jak również ustalenie czynników determinujących nasilenie zachowań zdrowotnych. Materiał i metody: Zbadano 100 pacjentów z rozpoznaniem POChP (średnia wie…

Transitioning from Preclinical to Clinical Heart Failure with Preserved Ejection Fraction: A Mechanistic Approach.

2020

International audience; To better understand heart failure with preserved ejection fraction (HFpEF), we need to better characterize the transition from asymptomatic pre-HFpEF to symptomatic HFpEF. The current emphasis on left ventricular diastolic dysfunction must be redirected to microvascular inflammation and endothelial dysfunction that leads to cardiomyocyte remodeling and enhanced interstitial collagen deposition. A pre-HFpEF patient lacks signs or symptoms of heart failure (HF), has preserved left ventricular ejection fraction (LVEF) with incipient structural changes similar to HFpEF, and possesses elevated biomarkers of cardiac dysfunction. The transition from pre-HFpEF to symptomati…

Right Ventricular Dysfunction Staging System for Mortality Risk Stratification in Heart Failure with Preserved Ejection Fraction

2020

Right ventricular dysfunction (RVD) parameters are increasingly important features in heart failure with preserved ejection fraction (HFpEF). We sought to evaluate the prognostic impact of a progressive RVD staging system by combining the tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (TAPSE/PASP) ratio with functional tricuspid regurgitation (TR) severity. We prospectively included 1355 consecutive HFpEF patients discharged for acute heart failure (HF). Of them, in 471 (34.7%) patients, PASP could not be accurately measured, leaving the final sample size to be 884 patients. Patients were categorized as Stage 1: TAPSE/PASP &ge

Hydrophobin (HFBI): a potential fusion partner for one-step purification of recombinant proteins from insect cells

2008

Hydrophobins play an important role in binding and assembly of fungal surface structures as well as in medium-air interactions. These, hydrophobic properties provide interesting possibilities when purification of macromolecules is concerned. In aqueous micellar two-phase systems, based on surfactants, the water soluble hydrophobins are concentrated inside micellar structures and, thus, distributed to defined aqueous phases. This, one-step purification is attractive particularly when large-scale production of recombinant proteins is concerned. In the present study the hydrophobin HFBI of Trichoderma reesei was expressed as an N-terminal fusion with chicken avidin in baculovirus infected inse…

Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome

2010

Plasma leptin or VEGF are little affected by maximal exercise at high altitude (5050 m)

2010

Genome-wide association analysis identifies six new loci associated with forced vital capacity

2014

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic in…