Search results for "PUMP"
showing 10 items of 471 documents
Energy and economic analysis of air-to-air heat pumps as an alternative to domestic gas boiler heating systems in the South of Italy
2019
Abstract According to the electricity tariff recently issued by the Italian government for the domestic heating systems fed with heat pumps (HP), an energy and economic analysis was carried out with the aim of investigating the effectiveness of the air-to-air heat pump systems (HPS) as an alternative to the traditional heating using domestic gas boilers systems (GBS). For the purpose of this study, the apartments of three residential buildings were examined. The hourly heating loads were calculated with the ASHRAE radiant time series and the coefficient of performance (COP) of the HPs was evaluated for each operating condition. The costs for the heating system installation and electricity a…
Solar and Heat Pump Systems for Domestic Hot Water Production on a Small Island: The Case Study of Lampedusa
2020
The achievement of United Nations Sustainable Development Goals, related to energy and resource use, is a critical issue for small and insulated communities. In many minor islands, solar energy is not correctly exploited, and electrical heaters are connected to weak grids with very a high share of generation by fossil fuels. As a consequence, there is the necessity to assess the potential and the suitability of diffusion of alternative systems to avoid dependency on the electrical grid and reduce carbon emissions. This paper aims to evaluate the technical and economic performances of some alternative systems exploiting renewable energy for domestic hot water production. Four different syste…
Classification and Review of Pump-Controlled Differential Cylinder Drives
2019
Pump-controlled hydraulic cylinder drives may offer improved energy efficiency, compactness, and plug-and-play installation compared to conventional valve-controlled hydraulic systems and thus have the potential of replacing conventional hydraulic systems as well as electro-mechanical alternatives. Since the late 1980s, research into how to configure the hydraulic circuit of pump-controlled cylinder drives has been ongoing, especially in terms of compensating the uneven flow requirements required by a differential cylinder. Recently, research has also focused on other aspects such as replacing a vented oil tank with a small-volume pressurized accumulator including the consequences of this i…
A Novel Solution for the Elimination of Mode Switching in Pump-Controlled Single-Rod Cylinders
2020
This paper concerns the stability issue of pump-controlled single-rod cylinders, known as mode switching. First, a review of the topic is provided. Thereafter, the most recently proposed solution for the elimination of mode switching is investigated and shown to result in unstable behavior under certain operating conditions. A theoretical analysis is provided demonstrating the underlying mechanisms of this behavior. Based on the analysis, a novel control strategy is proposed and investigated numerically. Proper operation and stability are demonstrated for a wide range of operating conditions, including situations under which the most recently proposed solution results in unstable behavior a…
Thermo-Hydraulic Modelling and Experimental Validation of an Electro-Hydraulic Compact Drive
2021
Electro-hydraulic compact drives (ECDs) are an emerging technology for linear actuation in a wide range of applications. Especially within the low power range of 5–10 kW, the plug-and-play capability, good energy efficiency and small space requirements of ECDs render this technology a promising alternative to replace conventional valve-controlled linear drive solutions. In this power range, ECDs generally rely on passive cooling to keep oil and system temperatures within the tolerated range. When expanding the application range to larger power classes, passive cooling may not be sufficient. Research investigating the thermal behaviour of ECDs is limited but indeed required for a successful …
Heat Pump Induction Motor Faults Caused by Soft Starter Topology — Case Study
2021
This paper presents a case study of electrical machine faults, emerging in heat pump systems. In Nordic countries, heat pumps have been gaining popularity during the past years and have become one of the leading ways of heating in households and smaller public buildings. Although not a very complicated setup, the devices used are still prone to unexpected failures, especially if wrongly chosen, installed or maintained. The paper presents a study conducted on five real-life cases with very similar outcomes and failure modes. The setup of the systems is explained, faults are listed and presented, causes of the faults including modeling and measurement data are provided. The suggestions are gi…
The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disorders
2017
Selective degeneration of differentiated neurons in the brain is the unifying feature of neurodegenerative disorders such as Parkinson's disease (PD) or Alzheimer's disease (AD). A broad spectrum of evidence indicates that initially subtle, but temporally early calcium dysregulation may be central to the selective neuronal vulnerability observed in these slowly progressing, chronic disorders. Moreover, it has long been evident that excitotoxicity and its major toxic effector mechanism, neuronal calcium overload, play a decisive role in the propagation of secondary neuronal death after acute brain injury from trauma or ischemia. Under physiological conditions, neuronal calcium homeostasis is…
Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibrobla…
2018
Abstract Background Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules modulating myofibroblast differentiation and proliferation, respectively. There is evidence linking CD248 with these two molecules, both highly expressed in patients with SSc, and suggesting that CD248 may be a therapeutic target for several diseases. The aim of this work was to evaluate the expression of CD248 in SSc skin and its ability to modulate SSc fibrotic process. Methods After ethical approval was obtained, skin biopsies were co…
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells
2016
Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H+-VATPase), a proton pump overexpressed in several tumor cells, but this aspect has not been deeply investigated in EAC yet. In the present study, the expression of H+-VATPase was assessed through the metaplasia-dysplasia-adenocarcinoma sequence in Barrett’s esophagus (BE) and the antineoplastic effects of PPIs and cellular mechanisms involved were evaluated in vitro. H+-VATPase expression was assessed by immunohistochemistry in paraffined-embedded samples or by immunofluorescence in cultured BE and EAC cell lines. Cells we…
Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for Helicobacter pylori Infection: A Network Meta-analysis
2021
Background & Aims A number of double, triple, and quadruple therapies have been proposed as first-line empiric treatments for Helicobacter pylori infection. However, knowledge of their worldwide and regional comparative efficacy is lacking. We examined the comparative effectiveness of all empirically used first-line regimens tested against standard triple treatment using a network meta-analysis of published randomized controlled trials. Methods Data extracted from eligible randomized controlled trials were entered into a Bayesian network meta-analysis to investigate the comparative efficacy of H pylori infection empiric first-line regimens and to explore their effectiveness rank order. The …