Search results for "PYRAZOL"

showing 10 items of 720 documents

1-methil-3H-pyrazolo[1-2-a]benzo[1-2-3-4]tetrazin-3-ones, design synthesis and biological activity of new antitumoral agents

2005

1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, were designed as novel alkylating agents because of their peculiar chemical behavior. All derivatives showed antiproliferative activity against more than 50 types of tumor cell lines with GI50 reaching sub-micromolar values. SAR studies revealed that the presence of a chlorine atom is well-tolerated in both positions 8 and 9, whereas in the case of the methyl group, switching from the 8 to the 9 position gives rise to the most active compound of the series, 4g, either for the number of cell lines inhibited and for selectivity against leukaemia and renal cancer subpanels. COMPARE and 3D-MIND comp…

antiproliferative activityQuantitative structure–activity relationshipStereochemistry2-a]benzotetrazinoneQuantitative Structure-Activity RelationshipRifamycinsAntineoplastic Agents1-Methylpyrazolo[12-a]benzo[1234]tetrazin-3-oneChemical synthesischemistry.chemical_compoundantiproliferativeCell Line TumorDrug DiscoveryCOMPARE and 3D-MIND analysisHumansComputer Simulationpyrazolo[1CytotoxicityBiological activityCytidinechemistryDrug Designantitumor agentMolecular MedicinePyrazolesDrug Screening Assays AntitumorSelectivityHeterocyclic Compounds 3-RingMethyl group
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ChemInform Abstract: Exploring the Anticancer Potential of Pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one Derivatives: The Effect on Apoptosis Induction…

2013

Abstract In order to investigate their anticancer potential, four new pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinone derivatives, designed through the chemometric protocol VLAK, and three of the most active compounds of the previous series have been evaluated on some cellular events including proliferation, apoptosis induction, and cell cycle. The NCI one dose (10 μM) screening revealed that the 8,9-di-methyl derivative showed activity against Leukemia (CCRF-CEM) and Colon cancer cell line (COLO 205), reaching 81% and 45% of growth inhibition (GI), respectively. Replacement of the two methyl groups with two chlorine atoms maintained the activity toward Leukemia cell (CCRF-CEM, GI 77%) and selecti…

biology3Cell growthCell2Pyrazolo[1General MedicineCell cyclebiology.organism_classificationmedicine.diseaseHeLaLeukemiachemistry.chemical_compound2a ]benzo[1medicine.anatomical_structurechemistryApoptosis4]tetr azinone VLAK pro tocol Anticancer agents Apopt osis inducers Cell cy clemedicineCancer researchGrowth inhibitionEC50ChemInform
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CCDC 1491307: Experimental Crystal Structure Determination

2016

Related Article: Verónica Jornet-Mollá, Yan Duan, Carlos Giménez-Saiz, João C. Waerenborgh, Francisco M. Romero|2016|Dalton Trans.|45|17918|doi:10.1039/C6DT02934E

bis(26-bis(1H-pyrazol-3-yl)-pyridine)-iron hexanedioate tetrahydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1491308: Experimental Crystal Structure Determination

2016

Related Article: Verónica Jornet-Mollá, Yan Duan, Carlos Giménez-Saiz, João C. Waerenborgh, Francisco M. Romero|2016|Dalton Trans.|45|17918|doi:10.1039/C6DT02934E

bis(26-bis(1H-pyrazol-3-yl)pyridine)-iron terephthalate methanol solvate monohydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1979775: Experimental Crystal Structure Determination

2020

Related Article: Elena A. Mikhalyova, Matthias Zeller, Jerry P. Jasinski, Raymond J. Butcher, Luca M. Carrella, Alexander E. Sedykh, Konstantin S. Gavrilenko, Sergey S. Smola, Michael Frasso, Sebastian Calderon Cazorla, Kuluni Perera, Anni Shi, Habib G. Ranjbar, Casey Smith, Alexandru Deac, Youlin Liu, Sean M. McGee, Vladimir P. Dotsenko, Michael U. Kumke, Klaus Müller-Buschbaum, Eva Rentschler, Anthony W. Addison, Vitaly V. Pavlishchuk|2020|Dalton Trans.|49|7774|doi:10.1039/D0DT00600A

bis(hydrogen tripyrazolylborate)-(3-phenylacetylacetonato)-dysprosium n-heptane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1979776: Experimental Crystal Structure Determination

2020

Related Article: Elena A. Mikhalyova, Matthias Zeller, Jerry P. Jasinski, Raymond J. Butcher, Luca M. Carrella, Alexander E. Sedykh, Konstantin S. Gavrilenko, Sergey S. Smola, Michael Frasso, Sebastian Calderon Cazorla, Kuluni Perera, Anni Shi, Habib G. Ranjbar, Casey Smith, Alexandru Deac, Youlin Liu, Sean M. McGee, Vladimir P. Dotsenko, Michael U. Kumke, Klaus Müller-Buschbaum, Eva Rentschler, Anthony W. Addison, Vitaly V. Pavlishchuk|2020|Dalton Trans.|49|7774|doi:10.1039/D0DT00600A

bis(hydrogen tripyrazolylborate)-(3-phenylacetylacetonato)-europium n-hexane unknown solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2044705: Experimental Crystal Structure Determination

2021

Related Article: Sergiu Calancea, Luca Carrella, Teodora Mocanu, Vladimir Sadohin, Mihai Raduca, Iacob Gutu, Julio C. Rocha, Maria G. F. Vaz, Eva Rentschler, Marius Andruh|2021|Eur.J.Inorg.Chem.|2021|567|doi:10.1002/ejic.202000954

bis(mu-4455-tetramethyl-3-oxo-2-(5-phenyl-1H-pyrazol-4-yl)-45-dihydro-1H-3-imidazol-1-oxyl)-hexakis(111555-hexafluoroacetylacetonato)-di-gadolinium(iii)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 978949: Experimental Crystal Structure Determination

2014

Related Article: Ravindra Singh, Francesc Lloret and Rabindranath Mukherjee|2014|Z.Anorg.Allg.Chem.|640|1086|doi:10.1002/zaac.201400005

bis(mu2-chloro)-bis(N-methyl-N-(1H-pyrazol-1-ylmethyl)-2-(pyridin-2-yl)ethanamine)-tetrachloro-tri-copper(ii)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1856808: Experimental Crystal Structure Determination

2018

Related Article: Miguel Clemente Leon, Víctor García-López, Mario Palacios-Corella, Alexandre Abhervé, Isaac Pellicer-Carreño, Cédric Desplanches, Eugenio Coronado|2018|Dalton Trans.|47|16958|doi:10.1039/C8DT03511C

bis[26-bis(1H-pyrazol-1-yl)pyridine-4-carboxylic acid]-iron(ii) bis(hexafluoroantimonate) acetone solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1856811: Experimental Crystal Structure Determination

2018

Related Article: Miguel Clemente Leon, Víctor García-López, Mario Palacios-Corella, Alexandre Abhervé, Isaac Pellicer-Carreño, Cédric Desplanches, Eugenio Coronado|2018|Dalton Trans.|47|16958|doi:10.1039/C8DT03511C

bis[26-bis(1H-pyrazol-1-yl)pyridine-4-carboxylic acid]-iron(ii) bis(hexafluoroantimonate) acetone solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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