Search results for "PYRIDINE"

showing 10 items of 2516 documents

CCDC 1409981: Experimental Crystal Structure Determination

2015

Related Article: Paulina I. Hidalgo, Sergio Leal, Claudio A. Jiménez, Esteban Vöhringer-Martinez, Bárbara Herrera, Jorge Pasán, Catalina Ruiz-Pérez, Duncan W. Bruce|2016|CrystEngComm|18|42|doi:10.1039/C5CE02154E

4-(5-(4-(octyloxy)phenyl)-134-oxadiazol-2-yl)pyridine 135-trifluoro-246-triiodobenzeneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 620726: Experimental Crystal Structure Determination

2006

Related Article: C.Peifer, M.Abadleh, D.Schollmeyer, S.Laufer|2006|Acta Crystallogr.,Sect.E:Struct.Rep.Online|62|o3647|doi:10.1107/S1600536806029448

4-(5-(4-Fluorophenyl)-3-isopropylisoxazol-4-yl)pyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2068114: Experimental Crystal Structure Determination

2021

Related Article: Shilin Yu, Jas S. Ward, Khai-Nghi Truong, Kari Rissanen|2021|Angew.Chem.,Int.Ed.|60|20739|doi:10.1002/anie.202108126

4-(piperidin-1-yl)-1-{[(trifluoroacetyl)oxy]-iodanyl}-1-pyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2027280: Experimental Crystal Structure Determination

2020

Related Article: Christian Schumacher, Hannah Fergen, Rakesh Puttreddy, Khai-Nghi Truong, Torsten Rinesch, Kari Rissanen, Carsten Bolm|2020|Org.Chem.Front.|7|3896|doi:10.1039/D0QO01139H

4-{[(4-chlorophenyl)(methyl)oxo-lambda6-sulfanylidene]amino}-2356-tetrafluoropyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2027296: Experimental Crystal Structure Determination

2020

Related Article: Christian Schumacher, Hannah Fergen, Rakesh Puttreddy, Khai-Nghi Truong, Torsten Rinesch, Kari Rissanen, Carsten Bolm|2020|Org.Chem.Front.|7|3896|doi:10.1039/D0QO01139H

4-{[ethyl(oxo)phenyl-lambda6-sulfanylidene]amino}-2356-tetrafluoropyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1441505: Experimental Crystal Structure Determination

2018

Related Article: Michael G. S. Londesborough, Jiří Dolanský, Tomáš Jelínek, John D. Kennedy, Ivana Císařová, Robert D. Kennedy, Daniel Roca-Sanjuán, Antonio Francés-Monerris, Kamil Lang, William Clegg|2018|Dalton Trans.|47|1709|doi:10.1039/C7DT03823B

5'6':56-conjuncto-(10'-(pyridine-N)-6'7':8'9'-di-muH-nido-decaborane)-(67:89:910-tri-muH-nido-decaborane)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2026029: Experimental Crystal Structure Determination

2020

Related Article: Carmen Ramírez de Arellano, Rosa Adam, Rafael Ballesteros-Garrido, Belen Abarca, Rafael Ballesteros, Ibon Alcorta, José Elguero, Emilio Escrivà|2020|CrystEngComm|22|6979|doi:10.1039/D0CE01272F

7-(5-bromopyrimidin-4-yl)-3-methyl[123]triazolo[15-a]pyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 799866: Experimental Crystal Structure Determination

2011

Related Article: R.Ballesteros-Garrido, L.Bonnafoux, F.Blanco, R.Ballesteros, F.R.Leroux, B.Abarca, F.Colobert, I.Alkorta, J.Elguero|2011|Dalton Trans.|40|1387|doi:10.1039/c0dt01183e

7-(Diphenylphosphino)-3-methyl-[123]triazolo[15-a]pyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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New Tripentone Analogs with Antiproliferative Activity

2017

Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) and MCF-7 (human breast cancer). The most active derivative, with GI50 values of 4.25 µM and 20.73 µM for HCT-116 a…

8H-thieno[23-b]pyrrolizinonePyridinesPharmaceutical SciencetripentonesApoptosis01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryThiopheneCytotoxic T cellCytotoxicityMolecular StructureCell Cycletripentoneproapoptotic agentsCell cycleBiochemistryChemistry (miscellaneous)MCF-7 CellsMolecular Medicineaza-indolesAntineoplastic Agents010402 general chemistryArticlelcsh:QD241-441Structure-Activity Relationshiplcsh:Organic chemistryCell Line TumormedicineHumansantitumor activityPhysical and Theoretical ChemistryMode of actionCell ProliferationDose-Response Relationship Drug010405 organic chemistryOrganic ChemistryCancermedicine.diseaseHCT116 CellsSettore CHIM/08 - Chimica Farmaceutica0104 chemical sciences8H-thieno[23-b]pyrrolizinoneschemistryApoptosisCell cultureaza-indoletripentones; aza-indoles; 8<i>H</i>-thieno[23-<i>b</i>]pyrrolizinones; antitumor activity; proapoptotic agentsCaco-2 CellsMolecules; Volume 22; Issue 11; Pages: 2005
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Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.

2016

Four ruthenium complexes of clinically used zinc ionophore pyrithione and its oxygen analog 2-hydroxypyridine N-oxide were prepared and evaluated as inhibitors of enzymes of the aldo–keto reductase subfamily 1C (AKR1C). A kinetic study assisted with docking simulations showed a mixed type of inhibition consisting of a fast reversible and a slow irreversible step in the case of both organometallic compounds 1A and 1B. Both compounds also showed a remarkable selectivity towards AKR1C1 and AKR1C3 which are targets for breast cancer drug design. The organoruthenium complex of ligand pyrithione as well as pyrithione itself also displayed toxicity on the hormone-dependent MCF-7 breast cancer cell…

AKR1C1StereochemistryPyridinesIonophoreAldo-Keto Reductaseschemistry.chemical_elementAntineoplastic AgentsZincReductase010402 general chemistry01 natural sciencesRutheniumInorganic ChemistryCoordination ComplexesHumansCell Proliferationchemistry.chemical_classificationAldo-keto reductase010405 organic chemistryChemistryThiones0104 chemical sciencesRutheniumEnzymeDocking (molecular)MCF-7 CellsDalton transactions (Cambridge, England : 2003)
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