Search results for "Pact"
showing 10 items of 2355 documents
Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis
2020
[Background]: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.
Experience of medical students mentoring in an acute geriatric unit: Use of evidence-based medicine
2019
International audience; n a retrospective study, we studied the learning experience of second and third year undergraduate medical students in the acute geriatric unit of a University Hospital.Students who did not receive Evidence based medicine (EBM) classes had lower grades than those who did in the final theoretical and practical evaluations (p < .01).Our experience suggested that the implementation of EBM in the curriculum through small, structured semiology courses tailored to the specificities of the elderly improved Evidence based practices for undergraduate medical students. EBM should improve instruction and mentoring during undergraduate students' clinical rotation.
Improvement of asymmetric thyroid eye disease with teprotumumab
2021
PurposeTeprotumumab, a specific blocking antibody to the insulin like growth factor 1 receptor, significantly reduced proptosis in patients with thyroid eye disease (TED) in recent clinical trials. Given its specificity, we expect it to demonstrate greater efficacy on the worse affected orbit, in patients with asymmetric TED. Herein, we investigate the differential impact of teprotumumab on the orbits of such patients.MethodsIn this pooled analysis of patients who were enrolled in the recent phase 2 (NCT01868997) and phase 3 (NCT03298867) trials, all patients with asymmetric TED (difference in exophthalmometry of ≥3 mm) were screened for eligibility. The primary outcomes of the trials, prop…
Self-selected running gait modifications reduce acute impact loading, awkwardness, and effort
2021
Impact loading has been associated with running-related injuries, and gait retraining has been suggested as a means of reducing impact loading and lowering the risk of injury. However, gait retraining can lead to increased perceived awkwardness and effort. The influence of specifically trained and self-selected running gait modifications on acute impact loading, perceived awkwardness and effort is currently unclear. Sixteen habitual rearfoot/midfoot runners performed forefoot strike pattern, increased step rate, anterior trunk lean and self-selected running gait modifications on an instrumented treadmill based on real-time biofeedback. Impact loading, perceived awkwardness and effort scores…
Disposal Behavior of Used Masks during the COVID-19 Pandemic in the Moroccan Community: Potential Environmental Impact.
2021
The spread of coronavirus disease-2019 (COVID-19) levied on the Moroccan authorities to increase their mask production capacity, which reached up to 12 million facemask units produced per day. This increase in personal protective equipment (PPE) production and consumption is an efficient tool to address the spread of COVID-19. However, this results in more plastic and microplastic debris being added into the land and marine environments, which will harm the ecosystem, wildlife, and public health. Such a situation needs deep individual behavior observation and tracking, as well as an assessment of the potential environmental impact of this new type of waste. For this reason, we assessed the …
Intake of Tomato-Enriched Diet Protects from 6-Hydroxydopamine-Induced Degeneration of Rat Nigral Dopaminergic Neurons
2009
There is extensive evidence that oxidative damage of dopamine (DA)-containing neurons in the substantia nigra pars compacta (SNc) may contribute to the pathogenesis of Parkinson’s disease (PD). We evaluated the potential neuroprotective effect of diets enriched with wild-type Red Setter (RS) tomato or transgenic High Carotene (HC) tomato, rich in β-carotene, obtained by the activation of lycopene β-cyclase (tlcy-b), in an animal model of PD. Male Fischer 344 rats were fed for 14 days with standard AltrominMT diet, 5% RS- or 5% HC-enriched diet. Seven days after the beginning of this diet regimen, the rats were lesioned by 6-hydroxydopamine (6-OHDA) injected into the left SNc. After further …
Prospective external validation of a predictive score for postoperative pulmonary complications.
2015
Abstract Background: No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe). Methods: Sixty-three centers recruited 5,859 surgical patients receiving general, neuraxial, or plexus block anesthesia. The Assess Respiratory Risk in Surgical Patients in Catalonia factors (age, preoperative arterial oxygen saturation in air, acute respiratory infection during the previous month, preoperative anemia, upp…
Prosthetic rehabilitation with dental implants after treatment of a keratocystic odontogenic tumor. Case report
2011
Keratocystic odontogenic tumor (KCOT), formerly known as the odontogenic keratocyst (OKC) is a benign intraosseous lesion, characterized by invasive growth and high rate of recurrences. Although it is not frequently seen, KCOT may be associated with unerupted teeth and without relevant histopathological examinations, might be mistaken with dentigerous cyst. A 26 year-old male patient referred to our department with complaints of two months persisting painless swelling on the left side of mandible. Clinical and radiographic examinations revealed an impaction of the horizontally positioned left lower second premolar surrounded by a well-circumscribed radiolucent mass, located between the left…
Posterior Wall Fractures of the Acetabulum: Characteristics, Management, Prognosis
2001
A consecutive series of 60 fractures of the posterior wall of the acetabulum, treated operatively in a Level I Trauma center, is reviewed retrospectively. Characteristics of the lesion, type of treatment, early and late postoperative complications and two-year functional results were recorded. In 27 patients (45%), additional damage to the cartilage of the acetabular cavity such as subchondral impaction, free articular fragments or separation of the posterior wall into several pieces was present. Seven patients (11.6%) showed preoperative neurological deficit. All fractures were treated with open reduction and internal fixation through a Kocher-Langenbeck approach. Secondary nerve damage wa…